GENE VIEW

Tnc

MOUSE GENE INFORMATION [PubMed]
Description tenascin C
Synonyms cytotactin; hexabrachion; tenascin-C; Hxb; TN; TN-C; C130033P17Rik
Chromosome 4
Genetic Map Distance 34.06 cM
RefSeq Accessions NM_011607; NP_035737
NCBI Entrez Gene 21923 at chr4:63620819-63681760 (mm9) / chr4:63959785-64047015 (mm10)
Ensembl Gene ENSMUSG00000028364
VEGA Gene OTTMUSG00000000302
MGI Gene MGI:101922
Mouse Protein (6)
UniProt ID Description Length (AA) Predicted # TMs
Q80YX1 Tenascin 2110 0
Q148T4 Tnc protein 1564 0
Q148T5 Tenascin C, isoform CRA_a 1564 0
Q80YX0 Tenascin C (Hexabrachion) 832 0
Q8C9Z1 Putative uncharacterized protein (Fragment) 56 0
Q9WUU4 Fibronectin type III (Fragment) 91 0
Pfam Domains EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; EGF_2; fn3; Pfam-B_2000; fn3; fn3; Pfam-B_2000; fn3; Pfam-B_2000; fn3; fn3; Pfam-B_2000; fn3; fn3; fn3; fn3; fn3; Pfam-B_2000; fn3; fn3; Pfam-B_2000; fn3; Fibrinogen_C
Mouse alleles (5)
Allele Name Allele Type
Tnctm1a(EUCOMM)Wtsi EUCOMM-projects
Tnctm1e(EUCOMM)Wtsi EUCOMM-projects
Tnctm1Msch Targeted (knock-out)
Tnctm1Ref Targeted (knock-out)
Tnctm1Sia Targeted (Reporter)
Human Homolog TNC (tenascin C)
Human synonyms 150-225; GMEM; GP; HXB; JI; TN; TN-C
Human cytoband 9q33
Known deafness gene DFNA56
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (3)
ENSGALG00000007113 (TENA_CHICK) encoding ENSGALP00000011506
ENSGALG00000007113 (TENA_CHICK) encoding ENSGALP00000011507
ENSGALG00000007113 (TENA_CHICK) encoding ENSGALP00000011509
Gene Ontology
Biological Process (8) cell adhesion; signal transduction; neuromuscular junction development; positive regulation of cell proliferation; mesenchymal-epithelial cell signaling involved in prostate gland development; prostate gland epithelium morphogenesis; positive regulation of gene expression; peripheral nervous system axon regeneration
Cellular Component (7) extracellular space; proteinaceous extracellular matrix; basement membrane; basement membrane; basement membrane; extracellular region; interstitial matrix
Molecular Function (3) receptor binding; syndecan binding; fibronectin binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
5695
6126
6270
3683
1964
1843
Cochlea GFP+ cells
806
934
6929
3181
1027
NA
Utricle GFP- cells
100
511
171
80
67
157
Cochlea GFP- cells
369
1030
2766
2218
1876
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
850
GFP+
3496
4.11
0.0406
Utricle
2222
Cochlea
2114
0.95
1
Embryonic
1946
Postnatal
2302
1.18
0.116
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17426365 11.85 ± 0.74 12.87 ± 0.44 [12.69] 1.09 0.527
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1593
1567
1629
3294
No bFGF
1383
1371
1360
1506
EGF
2380
2253
2294
2309
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
3294
No bFGF
1506
0.46
0.085
bFGF
3294
EGF
2309
0.70
0.000333
No bFGF
1506
EGF
2309
1.53
7.63e-5
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000011509
Symbol TNC
Description Tenascin C
log10 riBAQ in stereocilia (mean ± sd) -5.19 ± 0.20
log10 riBAQ in utricle (mean ± sd) -3.45 ± 0.09
Molecules per stereocilium (mean ± error with slope error) 9.59 ± 0.47
Corrected Molecules per stereocilium (mean ± sd) -98.47 ± 132.09
Stereocilium / Utricle ratio (mean ± sd) 0.02 ± 0.00
Enriched in the stereocilia (FDR < 0.05) FALSE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416342_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 49.4 55.83 66.9 504.51 2244.96 3021.63
Replicate 1 Call A P P P P P
Replicate 2 46.38 58.99 97.56 626.24 4224.71 3575.37
Replicate 2 Call A P P P P P
Replicate 3 69.37 59.2 106.68 337.84 2607.21 2602.31
Replicate 3 Call A P P P P P
Replicate 4 119.2 278.82 1465.29 3239.31
Replicate 4 Call P P P P
Mean 55.05 58.01 97.59 436.85 2635.54 3109.66
Standard Deviation 12.49 1.89 22.3 158.35 1161.65 407.78
Log2 Mean 5.76 5.86 6.58 8.7 11.26 11.59
Log2 Standard Deviation 0.31 0.05 0.36 0.53 0.63 0.19
 
Vestibular ganglion
Replicate 1 52.48 87.93 346.43 693.72 373.96 163.35
Replicate 1 Call A P P P P P
Replicate 2 56.77 84.18 856.68 326.24 994.61 155.32
Replicate 2 Call A P P P P P
Replicate 3 56.37 94.69 553.09 941.5 1015.26 127.31
Replicate 3 Call A P P P P P
Mean 55.21 88.93 585.4 653.82 794.61 148.66
Standard Deviation 2.37 5.33 256.65 309.56 364.44 18.92
Log2 Mean 5.79 6.47 9.1 9.22 9.5 7.21
Log2 Standard Deviation 0.06 0.09 0.65 0.79 0.82 0.19