GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description tectorin alpha
Synonyms [a]-tectorin; Tctna
Chromosome 9
Genetic Map Distance 23.63 cM
RefSeq Accessions NM_009347; NP_033373
NCBI Entrez Gene 21683 at chr9:42137705-42208012 (mm9) / chr9:42329622-42403122 (mm10)
Ensembl Gene ENSMUSG00000037705
VEGA Gene OTTMUSG00000034859
MGI Gene MGI:109575
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
O08523 Alpha-tectorin 2155 0
B7ZWA6 Tecta protein 2150 0
Pfam Domains NIDO; VWD; C8; TIL; VWD; C8; TIL; VWD; C8; TIL; VWD; C8; Zona_pellucida
Mouse alleles (5)
Allele Name Allele Type
Tectatm1e(EUCOMM)Hmgu EUCOMM-projects
Tectatm1a(EUCOMM)Hmgu EUCOMM-projects
Tectatm1.1Ogha Targeted (knock-in)
Tectatm1Gpr Targeted (knock-out)
Tectatm2Gpr Targeted (knock-in)
Human Homolog TECTA (tectorin alpha)
Human synonyms DFNA12; DFNA8; DFNB21
Human cytoband 11q22-q24
Known deafness gene DFNA8/DFNA12/DFNB21
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000006614 (TECTA) encoding ENSGALP00000010663
ENSGALG00000006614 (TECTA) encoding ENSGALP00000040065
Gene Ontology
Biological Process (2) cell-matrix adhesion; sensory perception of sound
Cellular Component (6) anchored to membrane; membrane; extracellular region; plasma membrane; proteinaceous extracellular matrix; proteinaceous extracellular matrix
Molecular Function (3) extracellular matrix structural constituent; extracellular matrix structural constituent; protein binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
34
325
133
83
276
98
Cochlea GFP+ cells
255
1432
316
559
490
NA
Utricle GFP- cells
36
208
255
230
275
110
Cochlea GFP- cells
246
162
366
463
300
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
241
GFP+
364
1.51
0.558
Utricle
172
Cochlea
459
2.66
0.99
Embryonic
337
Postnatal
282
0.84
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17525966 8.12 ± 0.30 7.69 ± 0.31 [8.09] 0.95 0.554
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
10
14
21
31
No bFGF
224
205
225
214
EGF
53
46
40
46
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
31
No bFGF
214
6.86
0.00315
bFGF
31
EGF
46
1.49
0.122
No bFGF
214
EGF
46
0.22
1.93e-24
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000010663
Symbol TECTA
Description Tectorin alpha
log10 riBAQ in stereocilia (mean ± sd) -3.60 ± 0.22
log10 riBAQ in utricle (mean ± sd) -3.22 ± 0.02
Molecules per stereocilium (mean ± error with slope error) 369.26 ± 25.17
Corrected Molecules per stereocilium (mean ± sd) 198.74 ± 245.52
Stereocilium / Utricle ratio (mean ± sd) 0.42 ± 0.03
Enriched in the stereocilia (FDR < 0.05) TRUE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1419632_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 40.52 67.88 24.68 99.74 124.56 32.71
Replicate 1 Call A P P P P A
Replicate 2 45.34 64.93 66.23 34.42 22.21 61.12
Replicate 2 Call P P P A A P
Replicate 3 55.39 69.24 72.47 201.9 49.32 35.98
Replicate 3 Call P P P P A M
Replicate 4 131.12 56.83 42.16 23.17
Replicate 4 Call P A P A
Mean 47.08 67.35 73.63 98.22 59.56 38.25
Standard Deviation 7.59 2.2 43.81 74.24 44.82 16.19
Log2 Mean 5.54 6.07 5.97 6.31 5.61 5.17
Log2 Standard Deviation 0.23 0.05 1 1.1 1.03 0.58
 
Vestibular ganglion
Replicate 1 70.53 118.23 36.6 20.81 26.44 98.61
Replicate 1 Call P P A A A P
Replicate 2 83.22 110.49 34.24 24.42 151.4 32.36
Replicate 2 Call P P A A P P
Replicate 3 85.02 73.89 12.89 12.57 65.11 22.71
Replicate 3 Call P P A A P P
Mean 79.59 100.87 27.91 19.27 80.98 51.23
Standard Deviation 7.9 23.68 13.06 6.07 63.97 41.32
Log2 Mean 6.31 6.63 4.66 4.21 6 5.38
Log2 Standard Deviation 0.15 0.37 0.84 0.5 1.26 1.11