SHIELD | Shared Harvard Inner-Ear Laboratory Database

GENE VIEW

Tbl1x

MOUSE GENE INFORMATION [PubMed]

Description

transducin (beta)-like 1 X-linked

Synonyms

Tbl1

Chromosome

Genetic Map Distance

38.31 cM

RefSeq Accessions

NM_020601; NP_065626

NCBI Entrez Gene

21372 at chrX:74756566-74905604 (mm9) / chr0:77510547-77662985 (mm10)

Ensembl Gene

ENSMUSG00000025246

VEGA Gene

OTTMUSG00000017892

MGI Gene

MGI:1336172

Mouse Protein (2)

UniProt ID	Description	Length (AA)	Predicted # TMs
Q9QXE7	F-box-like/WD repeat-containing protein TBL1X	527	0
B1AVT9	Transducin (Beta)-like 1 X-linked	527	0

Pfam Domains

LisH; WD40; WD40; WD40; Pfam-B_2423; WD40; WD40; WD40; WD40

Mouse alleles (3)

Allele Name	Allele Type
Tbl1x^{tm1e(EUCOMM)Hmgu}	EUCOMM-projects
Tbl1x^{tm1a(EUCOMM)Hmgu}	EUCOMM-projects
Tbl1x^{tm1(KOMP)Vlcg}	KOMP-Regeneron-Project

Human Homolog

TBL1X (transducin (beta)-like 1X-linked)

Human synonyms

EBI; SMAP55; TBL1

Human cytoband

Xp22.3

Known deafness gene

Within mapped deafness loci

DFNX4 (DFN6)

Associated Human Disease in OMIM

None

Chicken homolog (1)

ENSGALG00000013366 (TBL1X) encoding ENSGALP00000021770

Gene Ontology

Biological Process (15)	proteolysis; sensory perception of sound; positive regulation of transcription; DNA-dependent; canonical Wnt receptor signaling pathway; negative regulation of transcription; DNA-dependent; fat cell differentiation; proteasomal ubiquitin-dependent protein catabolic process; response to estrogen stimulus; response to steroid hormone stimulus; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription; DNA-dependent; transcription; DNA-dependent; negative regulation of transcription from RNA polymerase II promoter
Cellular Component (4)	nucleus; spindle microtubule; transcriptional repressor complex; transcription factor complex
Molecular Function (13)	histone binding; chromatin binding; transcription regulatory region DNA binding; transcription regulatory region DNA binding; beta-catenin binding; protein C-terminus binding; transcription factor binding; protein domain specific binding; protein binding; protein binding; DNA binding; transcription corepressor activity; transcription corepressor activity

FACS-Sorted Hair Cells

Data | Chart

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
GFP-	48	GFP+	39	0.81	1
Utricle	31	Cochlea	58	1.84	1
Embryonic	39	Postnatal	46	1.17	0.993

Adult Cochlear Inner and Outer Hair Cells

Probeset ID	IHC (mean ± sd)	OHC (mean ± sd) [OHC replicate]	Fold Change (OHC/IHC)	False Discovery Rate (FDR)
17536005	121.74 ± 7.49	98.01 ± 17.48 [126.10]	0.81	0.504

Otic Progenitor Cells

Data

Growth Factor	Replicate 1	Replicate 2	Replicate 3	Mean
bFGF	1843	1874	1667	1874
No bFGF	2002	1896	1877	1911
EGF	1680	1531	1493	1568

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
bFGF	1874	No bFGF	1911	1.02	1
bFGF	1874	EGF	1568	0.84	0.116
No bFGF	1911	EGF	1568	0.82	0.078

Chicken Stereocilium Proteomics

Protein ID	ENSGALP00000021770
Symbol	TBL1Y
Description	Transducin (beta)-like 1, Y-linked
log10 riBAQ in stereocilia (mean ± sd)	ND
log10 riBAQ in utricle (mean ± sd)	-4.89 ± 0.07
Molecules per stereocilium (mean ± error with slope error)	ND
Corrected Molecules per stereocilium (mean ± sd)	ND
Stereocilium / Utricle ratio (mean ± sd)	UTR only
Enriched in the stereocilia (FDR < 0.05)	NA

Auditory and Vestibular Ganglion Neurons

Probe set ID: 1434643_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	858.95	249.93	335.79	178.05	354.73	420.14
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	893.36	278.11	427.93	379.47	220.57	496.44
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	977.66	350.48	381.36	178.34	458.07	283.36
Replicate 3 Call	P	P	P	A	P	M
Replicate 4			487	191	534.87	314.05
Replicate 4 Call			P	A	P	A
Mean	909.99	292.84	408.02	231.72	392.06	378.5
Standard Deviation	61.08	51.87	64.71	98.69	136.08	98.06
Log2 Mean	9.83	8.18	8.66	7.77	8.54	8.53
Log2 Standard Deviation	0.1	0.25	0.23	0.53	0.56	0.37

Vestibular ganglion
Replicate 1	844.29	301.95	399	235.39	173.08	276.89
Replicate 1 Call	P	P	P	P	A	P
Replicate 2	895.22	371.62	347.81	147.02	304.13	277.48
Replicate 2 Call	P	P	P	A	P	A
Replicate 3	904.6	326.11	313.53	170.92	229.55	326.07
Replicate 3 Call	P	P	P	A	M	P
Mean	881.37	333.23	353.45	184.44	235.59	293.48
Standard Deviation	32.45	35.38	43.01	45.71	65.73	28.23
Log2 Mean	9.78	8.38	8.46	7.5	7.84	8.19
Log2 Standard Deviation	0.05	0.15	0.17	0.35	0.41	0.14

Probe set ID: 1434644_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	103.84	122.23	228.04	151.48	172.62	143.52
Replicate 1 Call	P	P	P	P	A	P
Replicate 2	118.7	140.83	280.14	167.63	182.95	146.06
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	123.08	220.14	288.41	172.05	145.69	211.72
Replicate 3 Call	P	P	P	P	P	P
Replicate 4			315.87	145.65	230.63	174.18
Replicate 4 Call			P	P	P	P
Mean	115.21	161.07	278.12	159.2	182.97	168.87
Standard Deviation	10.08	52	36.71	12.64	35.44	31.77
Log2 Mean	6.84	7.28	8.11	7.31	7.5	7.38
Log2 Standard Deviation	0.13	0.44	0.2	0.11	0.27	0.26

Vestibular ganglion
Replicate 1	59.84	125.36	81.31	85.97	111.47	130.34
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	79.89	118.99	133.24	198.08	134.34	81.81
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	63.73	118.49	212.62	175.12	154.77	134.91
Replicate 3 Call	P	P	P	P	P	P
Mean	67.82	120.95	142.39	153.06	133.53	115.69
Standard Deviation	10.63	3.83	66.13	59.22	21.66	29.43
Log2 Mean	6.07	6.92	7.05	7.17	7.05	6.82
Log2 Standard Deviation	0.22	0.05	0.69	0.65	0.24	0.4

Probe set ID: 1455042_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	3284.3	2235.14	2666.77	3231.01	3447.88	3960.61
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	3285.14	2728.01	2749.82	3538.47	3380.05	3508.69
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	3160.7	2981.3	2601.61	2577.05	3440.86	3105.07
Replicate 3 Call	P	P	P	P	P	P
Replicate 4			2877.96	2490.96	3306.39	2758.11
Replicate 4 Call			P	P	P	P
Mean	3243.38	2648.15	2724.04	2959.37	3393.8	3333.12
Standard Deviation	71.6	379.44	119.2	508.17	65.75	518.72
Log2 Mean	11.66	11.36	11.41	11.52	11.73	11.69
Log2 Standard Deviation	0.03	0.21	0.06	0.25	0.03	0.22

Vestibular ganglion
Replicate 1	3105.62	3050.93	2608.78	2138.59	1707.35	1837.18
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	3137.68	3046.75	2794.91	2510.21	2362.15	1739.7
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	3155.7	2910.7	2213.67	2390.64	2511.98	2047.74
Replicate 3 Call	P	P	P	P	P	P
Mean	3133	3002.79	2539.12	2346.48	2193.83	1874.87
Standard Deviation	25.37	79.78	296.82	189.7	427.91	157.44
Log2 Mean	11.61	11.55	11.3	11.19	11.08	10.87
Log2 Standard Deviation	0.01	0.04	0.17	0.12	0.3	0.12

Utricle GFP+ cells

Cochlea GFP+ cells

Utricle GFP- cells

Cochlea GFP- cells