GENE VIEW

S1pr2

MOUSE GENE INFORMATION [PubMed]

Description

sphingosine-1-phosphate receptor 2

Synonyms

Edg5; H218; 1100001A16Rik; Gpcr13; S1P2; LPb2

Chromosome

9

Genetic Map Distance

7.68 cM

RefSeq Accessions

NM_010333; NP_034463

NCBI Entrez Gene

14739 at chr9:20770396-20781237 (mm9) / chr9:20965952-20976793 (mm10)

Ensembl Gene

ENSMUSG00000043895

VEGA Gene

MGI Gene

Mouse Protein (3)

UniProt ID	Description	Length (AA)	Predicted # TMs
P52592	Sphingosine 1-phosphate receptor 2	352	7
Q3U5W6	Putative uncharacterized protein	352	7
Q8C3Q7	Endothelial differentiation, sphingolipid G-protein-coupled receptor, 5	352	7

Pfam Domains

7tm_1

Mouse alleles (6)

Allele Name	Allele Type
S1pr2^{tm1e(EUCOMM)Wtsi}	EUCOMM-projects
S1pr2^tm1Ajml	Targeted (Reporter)
S1pr2^tm1Jch	Targeted (knock-out)
S1pr2^tm1Rlp	Targeted (knock-out)
S1pr2^tm1Ytak	Targeted (knock-out)
S1pr2^tm2Ytak	Targeted (Reporter)

Human Homolog

S1PR2 (sphingosine-1-phosphate receptor 2)

Human synonyms

AGR16; EDG-5; EDG5; Gpcr13; H218; LPB2; S1P2

Human cytoband

19p13.2

Known deafness gene

No

Within mapped deafness loci

DFNA57; DFNB68

Associated Human Disease in OMIM

None

Chicken homolog (0)

Biological Process (3)	G-protein coupled receptor signaling pathway; signal transduction; behavior
Cellular Component (4)	membrane; integral to membrane; integral to membrane; plasma membrane
Molecular Function (4)	sphingosine-1-phosphate receptor activity; G-protein coupled receptor activity; signal transducer activity; receptor activity

FACS-Sorted Hair Cells

Data | Chart

	E16a	E16b	P0	P4	P7	P16
Utricle GFP+ cells	13	11	17	6	26	19
Cochlea GFP+ cells	15	55	6	10	8	NA
Utricle GFP- cells	170	55	39	51	128	0
Cochlea GFP- cells	135	85	73	77	64	NA

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
GFP-	80	GFP+	17	0.22	0.124
Utricle	44	Cochlea	53	1.19	1
Embryonic	67	Postnatal	37	0.56	0.387

Adult Cochlear Inner and Outer Hair Cells

Probeset ID	IHC (mean ± sd)	OHC (mean ± sd) [OHC replicate]	Fold Change (OHC/IHC)	False Discovery Rate (FDR)
17524578	87.28 ± 11.57	59.76 ± 5.44 [56.97]	0.68	0.455

Otic Progenitor Cells

Data

Growth Factor	Replicate 1	Replicate 2	Replicate 3	Mean
bFGF	510	518	548	1081
No bFGF	388	401	414	416
EGF	94	118	128	114

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
bFGF	1081	No bFGF	416	0.38	0.0175
bFGF	1081	EGF	114	0.11	1.86e-94
No bFGF	416	EGF	114	0.27	7.79e-26

Chicken Stereocilium Proteomics

No chicken homolog has been identified for S1pr2.

Auditory and Vestibular Ganglion Neurons

Probe set ID: 1428176_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	90.32	143.14	148.54	55.15	87.26	157.22
Replicate 1 Call	M	P	P	A	A	P
Replicate 2	109.63	119.97	118.58	213.64	53.5	100.94
Replicate 2 Call	P	P	P	P	A	P
Replicate 3	120.8	126.74	117.74	25.9	174.2	63.91
Replicate 3 Call	A	P	P	A	P	P
Replicate 4			88.17	63.38	193.6	80.54
Replicate 4 Call			P	A	P	P
Mean	106.92	129.95	118.26	89.52	127.14	100.65
Standard Deviation	15.42	11.91	24.65	84.3	67.44	40.64
Log2 Mean	6.73	7.02	6.86	6.05	6.81	6.57
Log2 Standard Deviation	0.21	0.13	0.31	1.26	0.87	0.55

Vestibular ganglion
Replicate 1	65.75	104.52	224.1	113.31	81.67	94.61
Replicate 1 Call	P	P	P	A	A	P
Replicate 2	58.08	61.36	179.85	123.67	100.33	87.33
Replicate 2 Call	A	P	P	A	A	P
Replicate 3	62.42	94.92	97.91	106.43	114.03	67.11
Replicate 3 Call	A	P	A	P	A	P
Mean	62.08	86.93	167.29	114.47	98.68	83.02
Standard Deviation	3.85	22.66	64.03	8.68	16.24	14.25
Log2 Mean	5.95	6.41	7.3	6.84	6.61	6.36
Log2 Standard Deviation	0.09	0.41	0.62	0.11	0.24	0.26