GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description POU domain, class 4, transcription factor 3
Synonyms Brn-3.1; Brn3c; Brn3.1
Chromosome 18
Genetic Map Distance 22.58 cM
RefSeq Accessions NM_138945; NP_620395
NCBI Entrez Gene 18998 at chr18:42554251-42555747 (mm9) / chr18:42394597-42396093 (mm10)
Ensembl Gene ENSMUSG00000024497
VEGA Gene
MGI Gene MGI:102523
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q63955 POU domain, class 4, transcription factor 3 338 0
A6H6N6 POU domain, class 4, transcription factor 3 338 0
Pfam Domains Pfam-B_6490; Pou; Homeobox
Mouse alleles (7)
Allele Name Allele Type
Pou4f3tm1(KOMP)Wtsi KOMP-CSD-Project
Pou4f3tm1(KOMP)Vlcg KOMP-Regeneron-Project
Pou4f3ddl Spontaneous
Pou4f3tm1.1Nat Targeted (Floxed/Frt)
Pou4f3tm1Rsd Targeted (knock-out)
Pou4f3tm1Whk Targeted (Reporter)
Pou4f3tm1Xia Targeted (knock-out)
Human Homolog POU4F3 (POU class 4 homeobox 3)
Human synonyms BRN3C; DFNA15
Human cytoband 5q32
Known deafness gene DFNA15
Within mapped deafness loci DFNA54; DFNB60
Associated Human Disease in OMIM
Chicken homolog (0)
Gene Ontology
Biological Process (19) inner ear morphogenesis; regulation of transcription; DNA-dependent; sensory perception of sound; sensory perception of sound; sensory perception of sound; neuromuscular process controlling balance; neuromuscular process controlling balance; inner ear development; inner ear development; inner ear receptor cell differentiation; inner ear receptor cell differentiation; neuron apoptosis; auditory receptor cell differentiation; axon extension involved in development; retinal ganglion cell axon guidance; neuromuscular process controlling balance; vestibulocochlear nerve development; auditory receptor cell differentiation; regulation of transcription from RNA polymerase II promoter
Cellular Component (5) nucleus; nucleus; nucleus; nucleus; transcription factor complex
Molecular Function (3) sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; DNA binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
3
10
9
9
6
Cochlea GFP+ cells
1
0
6
22
11
NA
Utricle GFP- cells
0
2
0
0
0
0
Cochlea GFP- cells
0
0
0
0
0
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
0
GFP+
7
41.83
0.0049
Utricle
3
Cochlea
4
1.15
1
Embryonic
1
Postnatal
5
3.67
0.424
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17350134 209.11 ± 12.26 135.22 ± 69.07 [131.06] 0.65 0.583
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
0
0
0
No bFGF
0
1
2
1
EGF
1
0
0
1
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
0
No bFGF
1
4.38
1
bFGF
0
EGF
1
4.66
0.436
No bFGF
1
EGF
1
1.06
1
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Pou4f3.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1422353_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 4.9 26 23.47 42.41 50 32.63
Replicate 1 Call A A A A A A
Replicate 2 40.13 34.14 20.89 43.79 40.44 32.59
Replicate 2 Call A A A A A A
Replicate 3 29.88 41.57 26.54 40.9 57.41 39.94
Replicate 3 Call A A A A A A
Replicate 4 27.54 33.59 45.27 42.87
Replicate 4 Call A A A A
Mean 24.97 33.9 24.61 40.17 48.28 37.01
Standard Deviation 18.12 7.79 3.02 4.54 7.23 5.22
Log2 Mean 4.17 5.06 4.61 5.32 5.58 5.2
Log2 Standard Deviation 1.64 0.34 0.18 0.17 0.21 0.2
 
Vestibular ganglion
Replicate 1 23.81 31.73 17.4 24.92 39.42 31.64
Replicate 1 Call A A A A A A
Replicate 2 57.63 25.58 3.6 31.93 34.07 43.46
Replicate 2 Call A A A A A A
Replicate 3 37.27 28.82 19.22 26.63 24.74 35.82
Replicate 3 Call A A A A A A
Mean 39.57 28.71 13.41 27.83 32.74 36.97
Standard Deviation 17.03 3.08 8.54 3.66 7.43 5.99
Log2 Mean 5.21 4.84 3.41 4.79 5.01 5.2
Log2 Standard Deviation 0.64 0.16 1.36 0.19 0.34 0.23