GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description peroxisomal biogenesis factor 1
Synonyms E330005K07Rik; peroxisome biogenesis factor 1; ZWS1; 5430414H02Rik
Chromosome 5
Genetic Map Distance 2.26 cM
RefSeq Accessions NM_027777; NM_177211; NP_082053
NCBI Entrez Gene 71382 at chr5:3596066-3637101 (mm9) / chr5:3596066-3637230 (mm10)
Ensembl Gene ENSMUSG00000005907
VEGA Gene OTTMUSG00000028545
MGI Gene MGI:1918632
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
Q8C4F5 Putative uncharacterized protein 123 3
Q8C2Z2 Putative uncharacterized protein 183 2
Q5BL07 Peroxisome biogenesis factor 1 1284 0
D3Z5A7 Uncharacterized protein 69 0
Pfam Domains PEX-2N; PEX-1N; AAA; AAA
Mouse alleles (2)
Allele Name Allele Type
Pex1tm1a(EUCOMM)Hmgu EUCOMM-projects
Pex1tm1e(EUCOMM)Hmgu EUCOMM-projects
Human Homolog PEX1 (peroxisomal biogenesis factor 1)
Human synonyms ZWS; ZWS1
Human cytoband 7q21.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000009410 (PEX1) encoding ENSGALP00000015313
Gene Ontology
Biological Process (8) protein targeting to peroxisome; peroxisome organization; protein import into peroxisome matrix; ATP catabolic process; metabolic process; microtubule-based peroxisome localization; protein transport; transport
Cellular Component (9) intracellular membrane-bounded organelle; nucleus; cytoplasm; membrane; peroxisomal membrane; peroxisomal membrane; peroxisome; peroxisome; cytosol
Molecular Function (9) protein C-terminus binding; protein complex binding; ATPase activity; coupled; nucleoside-triphosphatase activity; ATP binding; nucleotide binding; nucleotide binding; lipid binding; binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
34
72
67
79
40
58
Cochlea GFP+ cells
37
47
31
80
60
NA
Utricle GFP- cells
30
39
27
37
37
0
Cochlea GFP- cells
24
53
50
54
23
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
34
GFP+
55
1.62
0.857
Utricle
43
Cochlea
46
1.06
1
Embryonic
42
Postnatal
46
1.09
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17434333 30.63 ± 0.83 27.35 ± 2.02 [29.60] 0.89 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
393
392
359
386
No bFGF
381
369
410
356
EGF
396
343
361
367
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
386
No bFGF
356
0.92
1
bFGF
386
EGF
367
0.95
0.791
No bFGF
356
EGF
367
1.03
0.905
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000015313
Symbol PEX1
Description Peroxisomal biogenesis factor 1
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -5.11 ± 0.16
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1428716_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1020.57 997.13 1189.22 1169.39 748.44 876.45
Replicate 1 Call P P P P P P
Replicate 2 1091.83 1221.33 1308.32 846.95 1277 958.07
Replicate 2 Call P P P P P P
Replicate 3 1130.31 1255.39 1310.81 1234.01 1000.26 1013.66
Replicate 3 Call P P P P P P
Replicate 4 1285 1362.11 906.76 1272.06
Replicate 4 Call P P P P
Mean 1080.9 1157.95 1273.34 1153.12 983.12 1030.06
Standard Deviation 55.68 140.31 57.27 219.26 221.78 170.89
Log2 Mean 10.08 10.17 10.31 10.15 9.91 9.99
Log2 Standard Deviation 0.07 0.18 0.07 0.3 0.32 0.23
 
Vestibular ganglion
Replicate 1 1317.82 1469.28 1056.8 1205.45 1214.6 996.5
Replicate 1 Call P P P P P P
Replicate 2 1187.36 1483.1 1234.63 1117.59 1102.36 1202.19
Replicate 2 Call P P P P P P
Replicate 3 1225.33 1391.72 1244.07 1137.31 1218.11 1216.15
Replicate 3 Call P P P P P P
Mean 1243.5 1448.03 1178.5 1153.45 1178.36 1138.28
Standard Deviation 67.1 49.26 105.5 46.1 65.84 122.98
Log2 Mean 10.28 10.5 10.2 10.17 10.2 10.15
Log2 Standard Deviation 0.08 0.05 0.13 0.06 0.08 0.16
Probe set ID: 1430382_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 243.46 262.47 326.63 345.12 302.19 367.36
Replicate 1 Call P P P A A A
Replicate 2 294.05 274.72 320.11 292.4 343.13 378.95
Replicate 2 Call P P P A A A
Replicate 3 262.13 272.09 402.34 357.51 313.24 368.04
Replicate 3 Call P P P P A A
Replicate 4 411.13 311.32 272.86 364.22
Replicate 4 Call P A A A
Mean 266.55 269.76 365.05 326.59 307.86 369.64
Standard Deviation 25.58 6.45 48.34 30.01 29.04 6.42
Log2 Mean 8.05 8.08 8.5 8.35 8.26 8.53
Log2 Standard Deviation 0.14 0.03 0.19 0.13 0.14 0.02
 
Vestibular ganglion
Replicate 1 255.76 303.7 321.66 279.14 298.34 314.02
Replicate 1 Call A P A A A P
Replicate 2 275.52 276.48 294.06 386.85 247.5 311.46
Replicate 2 Call A P A A A P
Replicate 3 270.56 291.46 244.19 313.74 260.2 268.05
Replicate 3 Call P P A A A P
Mean 267.28 290.55 286.64 326.58 268.68 297.84
Standard Deviation 10.28 13.63 39.26 54.99 26.46 25.83
Log2 Mean 8.06 8.18 8.15 8.34 8.07 8.21
Log2 Standard Deviation 0.06 0.07 0.2 0.24 0.14 0.13
Probe set ID: 1440267_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 512.09 442.54 305.4 251.27 220.71 183.69
Replicate 1 Call P P P P P P
Replicate 2 555.84 538.26 367.68 140.89 142.12 83.04
Replicate 2 Call P P P P P A
Replicate 3 541.7 502.7 212.9 130.91 104.3 164.16
Replicate 3 Call P P P P P P
Replicate 4 254.53 108.01 173.55 225.99
Replicate 4 Call P A P P
Mean 536.54 494.5 285.13 157.77 160.17 164.22
Standard Deviation 22.33 48.38 66.78 63.83 49.3 59.96
Log2 Mean 9.07 8.95 8.13 7.22 7.27 7.27
Log2 Standard Deviation 0.06 0.14 0.34 0.52 0.46 0.63
 
Vestibular ganglion
Replicate 1 630.15 352.14 200.29 122.59 213.2 164.95
Replicate 1 Call P P P P P P
Replicate 2 618.34 525.55 393.27 467.03 84.02 196.78
Replicate 2 Call P P P P P P
Replicate 3 590.38 412.69 574.83 471.61 370.11 195.71
Replicate 3 Call P P P P P P
Mean 612.96 430.13 389.46 353.74 222.44 185.81
Standard Deviation 20.42 88.01 187.3 200.2 143.27 18.08
Log2 Mean 9.26 8.73 8.48 8.23 7.55 7.53
Log2 Standard Deviation 0.05 0.29 0.77 1.12 1.08 0.14