GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description mannan-binding lectin serine peptidase 1
Synonyms Crarf
Chromosome 16
Genetic Map Distance 14.23 cM
RefSeq Accessions NM_008555; NP_032581
NCBI Entrez Gene 17174 at chr16:23451858-23520663 (mm9) / chr16:23451785-23521068 (mm10)
Ensembl Gene ENSMUSG00000022887
VEGA Gene
MGI Gene MGI:88492
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
P98064 Mannan-binding lectin serine protease 1 704 0
Q8CIR9 Serine protease MASP3 (Fragment) 336 0
Pfam Domains CUB; EGF_CA; CUB; Sushi; Sushi; Trypsin
Mouse alleles (2)
Allele Name Allele Type
Masp1tm1(KOMP)Vlcg KOMP-Regeneron-Project
Masp1tm1Tefu Targeted (knock-out)
Human Homolog MASP1 (mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor))
Human synonyms CRARF; CRARF1; MAP1; MAp44; MASP; MASP3; PRSS5; RaRF
Human cytoband 3q27-q28
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (2)
ENSGALG00000007419 (Q6Q1Q8_CHICK) encoding ENSGALP00000011986
ENSGALG00000007419 (Q6Q1Q8_CHICK) encoding ENSGALP00000011987
Gene Ontology
Biological Process (7) complement activation; negative regulation of complement activation; proteolysis; proteolysis; innate immune response; complement activation; lectin pathway; complement activation; lectin pathway
Cellular Component (5) extracellular space; extracellular space; extracellular space; extracellular region; extracellular region
Molecular Function (14) protein homodimerization activity; metal ion binding; catalytic activity; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; calcium-dependent protein binding; calcium-dependent protein binding; hydrolase activity; calcium ion binding; calcium ion binding; peptidase activity; protein homodimerization activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
17
0
0
2
1
0
Cochlea GFP+ cells
3
1
1
4
1
NA
Utricle GFP- cells
0
0
0
0
0
0
Cochlea GFP- cells
0
1
0
0
4
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
0
GFP+
3
4.79
0.753
Utricle
1
Cochlea
1
1.09
1
Embryonic
3
Postnatal
1
0.34
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17329403 7.30 ± 0.44 8.13 ± 0.89 [9.33] 1.11 0.57
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
65
51
41
140
No bFGF
111
102
75
85
EGF
231
255
231
239
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
140
No bFGF
85
0.61
1
bFGF
140
EGF
239
1.70
0.000853
No bFGF
85
EGF
239
2.79
8.73e-10
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1419677_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 30.58 53.47 70.14 39.54 96.16 39.51
Replicate 1 Call A P P A P A
Replicate 2 19.97 32.52 71.87 48.39 50.26 79.95
Replicate 2 Call A A P P A A
Replicate 3 25.52 40.46 77.49 34.95 99.48 39.58
Replicate 3 Call A P P A P A
Replicate 4 51.4 45.04 112.13 63.24
Replicate 4 Call P A P A
Mean 25.36 42.15 67.73 41.98 89.51 55.57
Standard Deviation 5.31 10.58 11.33 5.94 27.05 19.72
Log2 Mean 4.64 5.37 6.06 5.38 6.42 5.73
Log2 Standard Deviation 0.31 0.36 0.26 0.21 0.52 0.51
 
Vestibular ganglion
Replicate 1 26.38 45.24 53.71 40.97 63.03 77.73
Replicate 1 Call A P A A A P
Replicate 2 27.1 40.54 37.99 65.48 62.32 71.91
Replicate 2 Call A P A A A P
Replicate 3 14.36 17.64 62.73 40.95 73.03 55.84
Replicate 3 Call A A A A A P
Mean 22.61 34.47 51.48 49.13 66.13 68.49
Standard Deviation 7.16 14.77 12.52 14.16 5.99 11.34
Log2 Mean 4.44 4.99 5.66 5.58 6.04 6.08
Log2 Standard Deviation 0.52 0.74 0.37 0.39 0.13 0.25
Probe set ID: 1425985_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 266.5 133 240.45 147.73 646.1 331.6
Replicate 1 Call P P P A A P
Replicate 2 271.14 151.73 287.88 136.51 334.42 185.66
Replicate 2 Call P P A A A A
Replicate 3 259.25 212.45 366.47 134.14 588.18 614.86
Replicate 3 Call A P P A P P
Replicate 4 459.63 80.45 856.57 501.77
Replicate 4 Call P A P P
Mean 265.63 165.73 338.61 124.71 606.32 408.47
Standard Deviation 5.99 41.53 95.97 30.09 214.84 188.73
Log2 Mean 8.05 7.34 8.36 6.92 9.17 8.54
Log2 Standard Deviation 0.03 0.35 0.41 0.4 0.57 0.76
 
Vestibular ganglion
Replicate 1 54.32 22.72 270.05 299.86 244.83 196.69
Replicate 1 Call A A A M A P
Replicate 2 49.4 55.03 440.45 215.06 310.89 195.13
Replicate 2 Call A A P A M P
Replicate 3 52.96 22.09 511.54 356.74 467 247.6
Replicate 3 Call A A P P P P
Mean 52.23 33.28 407.35 290.55 340.91 213.14
Standard Deviation 2.54 18.84 124.1 71.3 114.09 29.85
Log2 Mean 5.71 4.92 8.62 8.15 8.36 7.73
Log2 Standard Deviation 0.07 0.75 0.48 0.37 0.47 0.2