MOUSE GENE INFORMATION [PubMed]
Description | growth regulation by estrogen in breast cancer-like | ||||||||||||
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Synonyms | AK220484; mKIAA4095 | ||||||||||||
Chromosome | 18 | ||||||||||||
Genetic Map Distance | 5.00 cM | ||||||||||||
RefSeq Accessions | NM_001083628; NP_001077097 | ||||||||||||
NCBI Entrez Gene | 381157 at chr18:10325177-10562939 (mm9) / chr18:10325081-10562945 (mm10) | ||||||||||||
Ensembl Gene | ENSMUSG00000042942 | ||||||||||||
VEGA Gene | OTTMUSG00000037156 | ||||||||||||
MGI Gene | MGI:3576497 | ||||||||||||
Mouse Protein (2) |
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Pfam Domains | Pfam-B_6038; Pfam-B_7714; Pfam-B_12518 | ||||||||||||
Mouse alleles (2) |
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Human Homolog | GREB1L (growth regulation by estrogen in breast cancer-like) | ||||||||||||
Human synonyms | C18orf6; KIAA1772 | ||||||||||||
Human cytoband | 18q11.2 | ||||||||||||
Known deafness gene | No | ||||||||||||
Within mapped deafness loci | No | ||||||||||||
Associated Human Disease in OMIM |
None
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Chicken homolog (1) |
ENSGALG00000014935 (KIAA1772) encoding ENSGALP00000024043
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Gene Ontology
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FACS-Sorted Hair Cells
Data |
Chart

E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
|
---|---|---|---|---|---|---|
Utricle GFP+ cells |
69 |
95 |
34 |
11 |
5 |
65 |
Cochlea GFP+ cells |
22 |
64 |
3 |
1 |
0 |
NA |
Utricle GFP- cells |
31 |
58 |
21 |
11 |
9 |
78 |
Cochlea GFP- cells |
53 |
58 |
29 |
40 |
37 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
---|---|---|---|---|---|
GFP- |
39 |
GFP+ |
33 |
0.87 |
0.779 |
Utricle |
41 |
Cochlea |
31 |
0.76 |
1 |
Embryonic |
56 |
Postnatal |
25 |
0.44 |
0.781 |
Adult Cochlear Inner and Outer Hair Cells
Probeset ID | IHC (mean ± sd) | OHC (mean ± sd) [OHC replicate] | Fold Change (OHC/IHC) | False Discovery Rate (FDR) |
---|---|---|---|---|
17348320 | 5.91 ± 0.44 | 6.31 ± 0.83 [7.99] | 1.07 | 0.657 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
---|---|---|---|---|
bFGF |
78 |
88 |
73 |
124 |
No bFGF |
64 |
52 |
68 |
143 |
EGF |
238 |
237 |
244 |
240 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
---|---|---|---|---|---|
bFGF |
124 |
No bFGF |
143 |
1.15 |
1 |
bFGF |
124 |
EGF |
240 |
1.93 |
5.64e-5 |
No bFGF |
143 |
EGF |
240 |
1.68 |
0.00196 |
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia. |
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1439341_at
Age | E12 | E13 | E16 | P0 | P6 | P15 |
---|---|---|---|---|---|---|
Spiral ganglion | ||||||
Replicate 1 | 838.05 | 993.59 | 1332.35 | 719.45 | 514.15 | 482.34 |
Replicate 1 Call | P | P | P | P | P | P |
Replicate 2 | 806.42 | 1062.06 | 1573.11 | 1140.84 | 488.98 | 169.7 |
Replicate 2 Call | P | P | P | P | P | A |
Replicate 3 | 850.54 | 1204.89 | 1052.02 | 802.19 | 998.4 | 279.33 |
Replicate 3 Call | P | P | P | P | P | A |
Replicate 4 | 897.21 | 992.42 | 959.12 | 505.84 | ||
Replicate 4 Call | P | P | P | P | ||
Mean | 831.67 | 1086.85 | 1213.67 | 913.73 | 740.16 | 359.3 |
Standard Deviation | 22.74 | 107.81 | 299.76 | 189.7 | 276.17 | 162.23 |
Log2 Mean | 9.7 | 10.08 | 10.21 | 9.81 | 9.45 | 8.36 |
Log2 Standard Deviation | 0.04 | 0.14 | 0.36 | 0.3 | 0.56 | 0.74 |
Vestibular ganglion | ||||||
Replicate 1 | 1601.61 | 1817.86 | 1401.58 | 1198.35 | 951.66 | 782.91 |
Replicate 1 Call | P | P | P | P | P | P |
Replicate 2 | 1581.87 | 1787.21 | 1703.97 | 1319.55 | 895.9 | 926.2 |
Replicate 2 Call | P | P | P | P | P | P |
Replicate 3 | 1610.28 | 1893 | 1839.79 | 1218.19 | 1235.31 | 946.2 |
Replicate 3 Call | P | P | P | P | P | P |
Mean | 1597.92 | 1832.69 | 1648.45 | 1245.36 | 1027.62 | 885.1 |
Standard Deviation | 14.56 | 54.43 | 224.32 | 65.01 | 182.01 | 89.07 |
Log2 Mean | 10.64 | 10.84 | 10.68 | 10.28 | 9.99 | 9.78 |
Log2 Standard Deviation | 0.01 | 0.04 | 0.2 | 0.07 | 0.25 | 0.15 |
Probe set ID: 1442703_at
Age | E12 | E13 | E16 | P0 | P6 | P15 |
---|---|---|---|---|---|---|
Spiral ganglion | ||||||
Replicate 1 | 594.11 | 586.34 | 825.97 | 695.21 | 636.89 | 580.93 |
Replicate 1 Call | A | P | P | P | A | A |
Replicate 2 | 628.97 | 635.62 | 1012.48 | 690.72 | 690.41 | 622.07 |
Replicate 2 Call | A | P | P | A | A | A |
Replicate 3 | 519.49 | 596.42 | 804.52 | 646.31 | 405.68 | 691.79 |
Replicate 3 Call | M | P | A | A | A | A |
Replicate 4 | 871.39 | 587.21 | 1229.65 | 919.23 | ||
Replicate 4 Call | P | A | P | A | ||
Mean | 580.86 | 606.13 | 878.59 | 654.86 | 740.66 | 703.51 |
Standard Deviation | 55.93 | 26.03 | 93.51 | 50.21 | 348.62 | 150.92 |
Log2 Mean | 9.18 | 9.24 | 9.77 | 9.35 | 9.42 | 9.44 |
Log2 Standard Deviation | 0.14 | 0.06 | 0.15 | 0.11 | 0.66 | 0.29 |
Vestibular ganglion | ||||||
Replicate 1 | 613.87 | 636.39 | 534.02 | 523.49 | 416.14 | 621.08 |
Replicate 1 Call | P | P | A | A | A | P |
Replicate 2 | 648.54 | 636.56 | 509.03 | 594.94 | 492.45 | 648.02 |
Replicate 2 Call | P | P | P | P | A | A |
Replicate 3 | 586.22 | 592.77 | 470.94 | 576.43 | 448.8 | 643.17 |
Replicate 3 Call | P | P | A | P | A | P |
Mean | 616.21 | 621.91 | 504.66 | 564.95 | 452.46 | 637.42 |
Standard Deviation | 31.23 | 25.23 | 31.77 | 37.08 | 38.29 | 14.36 |
Log2 Mean | 9.27 | 9.28 | 8.98 | 9.14 | 8.82 | 9.32 |
Log2 Standard Deviation | 0.07 | 0.06 | 0.09 | 0.1 | 0.12 | 0.03 |