GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description growth factor receptor bound protein 2-associated protein 1
Synonyms
Chromosome 8
Genetic Map Distance 38.47 cM
RefSeq Accessions NM_021356; NP_067331
NCBI Entrez Gene 14388 at chr8:83288333-83404378 (mm9) / chr8:80764431-80880751 (mm10)
Ensembl Gene ENSMUSG00000031714
VEGA Gene
MGI Gene MGI:108088
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q9QYY0 GRB2-associated-binding protein 1 695 0
Q505A4 Gab1 protein 695 0
Pfam Domains PH; Pfam-B_13305
Mouse alleles (11)
Allele Name Allele Type
Gab1tm1a(EUCOMM)Wtsi EUCOMM-projects
Gab1tm1e(EUCOMM)Wtsi EUCOMM-projects
Gab1tm1Ajw Targeted (knock-out)
Gab1tm1Gsf Targeted (Floxed/Frt)
Gab1tm1Nmoc Targeted (Floxed/Frt)
Gab1tm1Thir Targeted (Reporter)
Gab1tm1Wbm Targeted (Reporter)
Gab1tm2Wbm Targeted (knock-in)
Gab1tm3Wbm Targeted (knock-in)
Gab1tm4Wbm Targeted (knock-in)
Gab1tm5Wbm Targeted (knock-in)
Human Homolog GAB1 (GRB2-associated binding protein 1)
Human synonyms
Human cytoband 4q31.21
Known deafness gene No
Within mapped deafness loci DFNB26
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000009898 (GAB1) encoding ENSGALP00000016076
Gene Ontology
Biological Process (12) epidermis development; heart development; epidermal growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of MAPKKK cascade; signal transduction; response to oxidative stress; regulation of cell migration; activation of JUN kinase activity; activation of MAPK activity; labyrinthine layer development; interleukin-6-mediated signaling pathway
Cellular Component (1) cytoplasm
Molecular Function (4) signal transducer activity; protein binding; receptor activity; phospholipid binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
871
590
161
795
779
294
Cochlea GFP+ cells
725
670
457
366
350
NA
Utricle GFP- cells
1531
581
824
1182
1934
1006
Cochlea GFP- cells
1538
668
677
1185
1156
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
1117
GFP+
551
0.49
0.408
Utricle
879
Cochlea
779
0.89
1
Embryonic
897
Postnatal
798
0.89
0.961
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17510823 105.51 ± 9.66 82.04 ± 23.76 [79.67] 0.78 0.603
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1943
1917
1939
1611
No bFGF
2851
2896
2956
2900
EGF
1199
1217
1240
1219
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1611
No bFGF
2900
1.80
0.46
bFGF
1611
EGF
1219
0.76
0.00847
No bFGF
2900
EGF
1219
0.42
1.75e-21
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1417693_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1723.28 2484.68 957.44 1854.03 2259.7 1823.17
Replicate 1 Call P P P P P P
Replicate 2 1801.96 2764.46 831.42 2826.95 1996.27 975.89
Replicate 2 Call P P P P P P
Replicate 3 1949.17 2774.42 781.96 737.17 2878.63 1149.12
Replicate 3 Call P P P P P P
Replicate 4 1022.12 786.89 2957.01 1183.88
Replicate 4 Call P P P P
Mean 1824.8 2674.52 898.24 1551.26 2522.9 1283.02
Standard Deviation 114.66 164.48 110.81 994.33 469.61 371.42
Log2 Mean 10.83 11.38 9.8 10.37 11.28 10.28
Log2 Standard Deviation 0.09 0.09 0.18 0.95 0.27 0.39
 
Vestibular ganglion
Replicate 1 2123.25 2564.03 3287.22 3051.35 2742.9 2626.64
Replicate 1 Call P P P P P P
Replicate 2 2037.96 2587.35 3202.32 3180.62 2993.18 2488.05
Replicate 2 Call P P P P P P
Replicate 3 1977.79 2546.72 2650.09 2783.96 3026.73 2899.36
Replicate 3 Call P P P P P P
Mean 2046.33 2566.03 3046.54 3005.31 2920.94 2671.35
Standard Deviation 73.09 20.39 345.95 202.3 155.09 209.27
Log2 Mean 11 11.33 11.57 11.55 11.51 11.38
Log2 Standard Deviation 0.05 0.01 0.17 0.1 0.08 0.11
Probe set ID: 1417694_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1471.65 2309.54 812.8 1410.65 1678.67 1453.92
Replicate 1 Call P P P P P P
Replicate 2 1564.29 2865.3 486.23 2409.31 1719.25 535.17
Replicate 2 Call P P P P P P
Replicate 3 1678.48 2849.19 468.9 591.55 2326.67 886.52
Replicate 3 Call P P P P P P
Replicate 4 683.5 595.47 2138.91 768.07
Replicate 4 Call P P P P
Mean 1571.47 2674.68 612.86 1251.75 1965.88 910.92
Standard Deviation 103.6 316.32 165.05 862.51 318.03 390.32
Log2 Mean 10.62 11.38 9.22 10.03 10.93 9.74
Log2 Standard Deviation 0.09 0.18 0.39 1 0.23 0.6
 
Vestibular ganglion
Replicate 1 1798.93 2317.79 2782.72 2932.2 2334.54 2734.72
Replicate 1 Call P P P P P P
Replicate 2 1714.26 2442.78 2765.85 2562.48 3050.7 2483.65
Replicate 2 Call P P P P P P
Replicate 3 1580.24 2197.84 2306.29 2400.36 2825.07 2809.86
Replicate 3 Call P P P P P P
Mean 1697.81 2319.47 2618.29 2631.68 2736.77 2676.08
Standard Deviation 110.27 122.48 270.33 272.59 366.15 170.83
Log2 Mean 10.73 11.18 11.35 11.36 11.41 11.38
Log2 Standard Deviation 0.09 0.08 0.15 0.15 0.2 0.09
Probe set ID: 1448814_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 74.57 62.92 42.89 72.87 53.44 66.98
Replicate 1 Call A A A A A A
Replicate 2 68.75 68.43 44.01 75.53 65.14 54.53
Replicate 2 Call A A A A A A
Replicate 3 75.42 70.66 42.43 67.68 84.34 63.32
Replicate 3 Call A A A A A A
Replicate 4 29.39 60.42 45.26 93.61
Replicate 4 Call A A A A
Mean 72.91 67.34 39.68 69.13 62.05 69.61
Standard Deviation 3.63 3.98 6.89 6.66 16.96 16.83
Log2 Mean 6.19 6.07 5.29 6.11 5.92 6.09
Log2 Standard Deviation 0.07 0.09 0.28 0.14 0.39 0.33
 
Vestibular ganglion
Replicate 1 81.9 61.46 82.93 71.91 127.83 71.8
Replicate 1 Call A A A A A A
Replicate 2 61.07 83.15 59.98 93.58 93.09 88.3
Replicate 2 Call A A A A A A
Replicate 3 50.37 80.71 59 110.1 77.89 86.18
Replicate 3 Call A A A A A A
Mean 64.45 75.11 67.3 91.86 99.6 82.09
Standard Deviation 16.03 11.88 13.54 19.15 25.6 8.98
Log2 Mean 5.98 6.22 6.05 6.5 6.61 6.35
Log2 Standard Deviation 0.35 0.24 0.28 0.31 0.36 0.16