GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description whirlin
Synonyms Dfnb31; C430046P22Rik; wi; 1110035G07Rik
Chromosome 4
Genetic Map Distance 33.97 cM
RefSeq Accessions NM_001008791; NM_001008792; NM_001008793; NM_001008794; NM_001008795; NM_001008796; NM_001008797; NM_001008798; NM_028640; NP_001008791; NP_001008792; NP_001008793; NP_001008794; NP_001008795; NP_001008796; NP_001008797; NP_001008798; NP_082916
NCBI Entrez Gene 73750 at chr4:63075944-63156985 (mm9) / chr4:63414909-63496079 (mm10)
Ensembl Gene ENSMUSG00000039137
VEGA Gene OTTMUSG00000000249
MGI Gene MGI:2682003
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q80VW5 Whirlin 918 0
B2RWY4 Whirlin 907 0
Q9CY67 Putative uncharacterized protein 115 0
Pfam Domains Pfam-B_4764; PDZ; PDZ; Pfam-B_8138; Pfam-B_4764; PDZ
Mouse alleles (8)
Allele Name Allele Type
Whrntm1a(EUCOMM)Wtsi EUCOMM-projects
Whrntm1e(EUCOMM)Wtsi EUCOMM-projects
Whrntm3a(EUCOMM)Wtsi EUCOMM-projects
Whrntm3e(EUCOMM)Wtsi EUCOMM-projects
Whrntm2e(EUCOMM)Wtsi EUCOMM-projects
Whrntm2a(EUCOMM)Wtsi EUCOMM-projects
Whrntm1Tili Targeted (knock-out)
Whrnwi Spontaneous
Human Homolog DFNB31 (deafness, autosomal recessive 31)
Human synonyms CIP98; USH2D; WHRN; WI
Human cytoband 9q32
Known deafness gene DFNB31/USH2D
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000006310 (DFNB31) encoding ENSGALP00000010189
Gene Ontology
Biological Process (3) sensory perception of sound; inner ear receptor stereocilium organization; inner ear receptor stereocilium organization
Cellular Component (20) neuronal cell body; dendritic shaft; synapse; photoreceptor inner segment; photoreceptor connecting cilium; stereocilium bundle; neuronal cell body; cytoplasm; cell projection; cilium; actin filament; stereocilia ankle link complex; stereocilium; stereocilium; stereocilium; stereocilium; membrane fraction; soluble fraction; axon; dendrite
Molecular Function (4) protein binding; protein binding; protein binding; protein domain specific binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
21
55
41
33
26
150
Cochlea GFP+ cells
7
11
39
86
31
NA
Utricle GFP- cells
6
36
23
0
4
330
Cochlea GFP- cells
7
19
52
18
20
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
47
GFP+
46
0.98
0.577
Utricle
60
Cochlea
29
0.49
1
Embryonic
20
Postnatal
61
2.96
0.45
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17426306 65.08 ± 4.35 36.43 ± 5.19 [34.67] 0.56 0.308
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
634
655
916
733
No bFGF
472
553
712
592
EGF
291
282
386
320
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
733
No bFGF
592
0.81
1
bFGF
733
EGF
320
0.44
3.66e-14
No bFGF
592
EGF
320
0.54
7.24e-8
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1432555_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1486.82 1232.27 1049.67 729.35 806.53 845.88
Replicate 1 Call P P P P P P
Replicate 2 1539.56 1113.11 1074.54 547.09 557.33 931.42
Replicate 2 Call P P P P P P
Replicate 3 1616.32 1161.02 971.21 518.27 617.39 734.78
Replicate 3 Call P A P P P P
Replicate 4 1305.76 480.15 301.53 549.62
Replicate 4 Call P P P P
Mean 1547.57 1168.8 1100.3 568.72 570.7 765.43
Standard Deviation 65.12 59.96 143.88 110.54 208.51 164.86
Log2 Mean 10.59 10.19 10.09 9.13 9.07 9.55
Log2 Standard Deviation 0.06 0.07 0.18 0.26 0.6 0.33
 
Vestibular ganglion
Replicate 1 1666.72 1017.74 382.43 311.35 430.54 639.23
Replicate 1 Call P P P P P P
Replicate 2 1751.91 1143.83 387.31 307.38 417.99 719.27
Replicate 2 Call P P P P P P
Replicate 3 1733.58 1033.21 423.84 497.74 551.74 541.37
Replicate 3 Call P P P P P P
Mean 1717.4 1064.93 397.86 372.16 466.76 633.29
Standard Deviation 44.84 68.77 22.63 108.78 73.86 89.1
Log2 Mean 10.75 10.05 8.63 8.5 8.86 9.3
Log2 Standard Deviation 0.04 0.09 0.08 0.4 0.22 0.21
Probe set ID: 1436485_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 26.58 33.18 22.36 29.26 51.71 63.66
Replicate 1 Call A A A A A A
Replicate 2 27.16 21.06 39.52 54.84 39.17 128.46
Replicate 2 Call A A A A A P
Replicate 3 26.88 31.86 50.08 22.93 70.05 69.98
Replicate 3 Call A A A A A A
Replicate 4 9.62 24.26 63.21 25.61
Replicate 4 Call A A A A
Mean 26.87 28.7 30.4 32.82 56.04 71.93
Standard Deviation 0.29 6.65 17.95 14.93 13.55 42.48
Log2 Mean 4.75 4.81 4.67 4.94 5.77 5.95
Log2 Standard Deviation 0.02 0.36 1.06 0.58 0.37 0.96
 
Vestibular ganglion
Replicate 1 13.5 31.41 18.53 41.97 39.35 50.2
Replicate 1 Call A A A A A A
Replicate 2 30.83 52.94 34.74 35.79 47.54 44.48
Replicate 2 Call A P A A A A
Replicate 3 29.54 31.97 24.88 33.16 33.51 50.98
Replicate 3 Call A P A A A A
Mean 24.62 38.77 26.05 36.97 40.13 48.55
Standard Deviation 9.65 12.27 8.17 4.52 7.05 3.55
Log2 Mean 4.53 5.23 4.66 5.2 5.31 5.6
Log2 Standard Deviation 0.67 0.43 0.45 0.17 0.25 0.11
Probe set ID: 1436486_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 37.06 60.29 39.05 26.08 59.99 80.57
Replicate 1 Call A P A A P P
Replicate 2 44.19 59.72 51.66 59.19 47.21 128.75
Replicate 2 Call A P P P A P
Replicate 3 24.79 41.78 62.35 23.37 83.45 48.9
Replicate 3 Call A A P A P M
Replicate 4 45.82 24.64 97.07 30.33
Replicate 4 Call A A P A
Mean 35.35 53.93 49.72 33.32 71.93 72.14
Standard Deviation 9.81 10.53 9.87 17.28 22.5 43.07
Log2 Mean 5.1 5.73 5.61 4.94 6.11 5.97
Log2 Standard Deviation 0.43 0.3 0.28 0.63 0.47 0.9
 
Vestibular ganglion
Replicate 1 45.71 70.61 25.72 28.13 51.97 45.93
Replicate 1 Call M P A A A P
Replicate 2 40.36 55.11 42.43 40.92 37.01 59.52
Replicate 2 Call A P A A A P
Replicate 3 36.19 57.14 46.71 39.58 50.76 53.5
Replicate 3 Call P P A A A P
Mean 40.75 60.95 38.29 36.21 46.58 52.98
Standard Deviation 4.77 8.42 11.09 7.03 8.31 6.81
Log2 Mean 5.34 5.92 5.21 5.16 5.53 5.72
Log2 Standard Deviation 0.17 0.19 0.46 0.3 0.27 0.19
Probe set ID: 1442507_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 167.41 95.07 133.8 206.16 222.37 274.35
Replicate 1 Call A A A A A A
Replicate 2 122.25 83.05 190.9 229.27 275.29 234.91
Replicate 2 Call A A A A A A
Replicate 3 172.08 56.51 228.08 233.83 125.63 329.41
Replicate 3 Call A A A A A A
Replicate 4 233.53 262.54 178.82 353.86
Replicate 4 Call A A A A
Mean 153.91 78.21 196.58 232.95 200.53 298.13
Standard Deviation 27.52 19.73 45.94 23.15 63.63 53.69
Log2 Mean 7.25 6.26 7.59 7.86 7.59 8.2
Log2 Standard Deviation 0.27 0.39 0.37 0.14 0.48 0.27
 
Vestibular ganglion
Replicate 1 163.47 137.75 116.4 82.87 80.28 52.46
Replicate 1 Call A A A A A A
Replicate 2 127.91 93.11 129.87 213.88 79.66 76.5
Replicate 2 Call A A A A A A
Replicate 3 148.48 125.31 126.46 205.98 116.53 60.6
Replicate 3 Call A A A A A A
Mean 146.62 118.72 124.24 167.58 92.16 63.19
Standard Deviation 17.85 23.04 7 73.46 21.11 12.23
Log2 Mean 7.19 6.87 6.96 7.27 6.5 5.96
Log2 Standard Deviation 0.18 0.29 0.08 0.77 0.31 0.27