GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description uroporphyrinogen decarboxylase
Synonyms Uro-d
Chromosome 4
Genetic Map Distance 53.41 cM
RefSeq Accessions NM_009478; NP_033504
NCBI Entrez Gene 22275 at chr4:116662822-116666980 (mm9) / chr4:116990212-116994437 (mm10)
Ensembl Gene ENSMUSG00000028684
VEGA Gene OTTMUSG00000009782
MGI Gene MGI:98916
Mouse Protein (1)
UniProt ID Description Length (AA) Predicted # TMs
P70697 Uroporphyrinogen decarboxylase 367 0
Pfam Domains URO-D
Mouse alleles (3)
Allele Name Allele Type
Urodtm1a(EUCOMM)Hmgu EUCOMM-projects
Urodtm1e(EUCOMM)Hmgu EUCOMM-projects
Urodtm1Kush Targeted (knock-out)
Human Homolog UROD (uroporphyrinogen decarboxylase)
Human synonyms PCT; UPD
Human cytoband 1p34
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000010219 (UROD) encoding ENSGALP00000016593
Gene Ontology
Biological Process (4) porphyrin-containing compound biosynthetic process; uroporphyrinogen III metabolic process; heme biosynthetic process; heme metabolic process
Cellular Component (5) cytosol; nucleus; cytoplasm; microtubule cytoskeleton; cytosol
Molecular Function (8) ferrous iron binding; lyase activity; carboxy-lyase activity; uroporphyrinogen decarboxylase activity; uroporphyrinogen decarboxylase activity; uroporphyrinogen decarboxylase activity; uroporphyrinogen decarboxylase activity; uroporphyrinogen decarboxylase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
82
0
124
99
179
91
Cochlea GFP+ cells
119
87
56
155
256
NA
Utricle GFP- cells
159
53
62
252
144
15
Cochlea GFP- cells
133
53
33
180
103
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
108
GFP+
113
1.05
1
Utricle
105
Cochlea
118
1.12
1
Embryonic
86
Postnatal
125
1.46
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17428735 89.10 ± 6.72 88.77 ± 16.07 [56.23] 1.00 0.977
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
993
928
947
1024
No bFGF
861
893
889
931
EGF
1158
1175
1107
1146
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1024
No bFGF
931
0.91
1
bFGF
1024
EGF
1146
1.12
0.405
No bFGF
931
EGF
1146
1.23
0.0962
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1417206_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 676.15 924.03 583.84 716.61 1769.77 1586.97
Replicate 1 Call A A A A A A
Replicate 2 726.25 1046.62 711.53 885.33 1283.18 1563.4
Replicate 2 Call A A A A A A
Replicate 3 769.78 1157.59 795.5 805.24 2002.14 1557.42
Replicate 3 Call A A A A P A
Replicate 4 647.11 768.39 1276.14 1729.56
Replicate 4 Call A M A A
Mean 724.06 1042.75 684.5 793.89 1582.81 1609.34
Standard Deviation 46.85 116.83 90.52 70.98 362.68 81.16
Log2 Mean 9.5 10.02 9.41 9.63 10.6 10.65
Log2 Standard Deviation 0.09 0.16 0.19 0.13 0.33 0.07
 
Vestibular ganglion
Replicate 1 552.92 796.38 806.67 614.25 1237.25 1342.89
Replicate 1 Call A A A A A P
Replicate 2 533.96 863.63 651.19 653.92 1246.85 1664.85
Replicate 2 Call A A A A A P
Replicate 3 472.03 840.69 556.77 579.65 1105.24 1619.12
Replicate 3 Call A A A A P P
Mean 519.64 833.57 671.54 615.94 1196.45 1542.29
Standard Deviation 42.3 34.19 126.19 37.16 79.13 174.19
Log2 Mean 9.02 9.7 9.37 9.26 10.22 10.58
Log2 Standard Deviation 0.12 0.06 0.27 0.09 0.1 0.17
Probe set ID: 1443849_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1253.26 1879.52 1309.73 1441.96 4123.62 3768.42
Replicate 1 Call P P P P P P
Replicate 2 1369.64 2087.66 1914.37 1794.91 2789.85 4304.9
Replicate 2 Call P P P P P P
Replicate 3 1366 2240.06 2009.25 1588.4 4544.64 4210.38
Replicate 3 Call P P P P P P
Replicate 4 1972.57 1609.06 2558.5 3311.09
Replicate 4 Call P P P P
Mean 1329.63 2069.08 1801.48 1608.58 3504.15 3898.7
Standard Deviation 66.17 180.99 330.15 144.79 978.24 456.22
Log2 Mean 10.38 11.01 10.79 10.65 11.73 11.92
Log2 Standard Deviation 0.07 0.13 0.29 0.13 0.41 0.17
 
Vestibular ganglion
Replicate 1 857.35 1623.44 1821.51 1594.29 2649.99 3082.65
Replicate 1 Call P P P P P P
Replicate 2 898.29 1590.08 1561.05 1406.47 2456.85 3793.24
Replicate 2 Call P P P P P P
Replicate 3 757.85 1665.97 1368.89 1256.43 2348.69 3739.06
Replicate 3 Call P P P P P P
Mean 837.83 1626.5 1583.82 1419.06 2485.18 3538.32
Standard Deviation 72.23 38.04 227.17 169.28 152.63 395.55
Log2 Mean 9.71 10.67 10.62 10.46 11.28 11.78
Log2 Standard Deviation 0.13 0.03 0.21 0.17 0.09 0.17