GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description transformation/transcription domain-associated protein
Synonyms transactivation/transformation-domain associated protein
Chromosome 5
Genetic Map Distance 84.77 cM
RefSeq Accessions NM_001081362; NP_001074831
NCBI Entrez Gene 100683 at chr5:145529661-145620642 (mm9) / chr5:144768097-144859778 (mm10)
Ensembl Gene ENSMUSG00000045482
VEGA Gene OTTMUSG00000017164
MGI Gene MGI:2153272
Mouse Protein (5)
UniProt ID Description Length (AA) Predicted # TMs
Q80YV3 Transformation/transcription domain-associated protein 2565 0
D3YY11 Uncharacterized protein 59 0
Q3TIP5 Putative uncharacterized protein 374 0
Q3UH32 Putative uncharacterized protein (Fragment) 2724 0
Q8BW25 Putative uncharacterized protein 267 0
Pfam Domains Pfam-B_57; Pfam-B_57; Pfam-B_57; Pfam-B_57; Pfam-B_57; FAT; Pfam-B_15392; Pfam-B_3474; Pfam-B_2057; Pfam-B_15392; PI3_PI4_kinase; FATC
Mouse alleles (4)
Allele Name Allele Type
Trraptm1e(EUCOMM)Wtsi EUCOMM-projects
Trraptm1a(EUCOMM)Wtsi EUCOMM-projects
Trraptm1.1Zqw Targeted (knock-out)
Trraptm1Zqw Targeted (knock-out)
Human Homolog TRRAP (transformation/transcription domain-associated protein)
Human synonyms PAF350/400; PAF400; STAF40; TR-AP; Tra1
Human cytoband 7q21.2-q22.1
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (2)
ENSGALG00000003596 (TRRAP) encoding ENSGALP00000005678
ENSGALG00000003596 (TRRAP) encoding ENSGALP00000040253
Gene Ontology
Biological Process (6) histone H4 acetylation; histone H2A acetylation; regulation of RNA biosynthetic process; histone deubiquitination; regulation of transcription; DNA-dependent; mitotic cell cycle checkpoint
Cellular Component (6) transcription factor TFTC complex; nucleus; STAGA complex; NuA4 histone acetyltransferase complex; transcription factor complex; histone acetyltransferase complex
Molecular Function (2) transcription cofactor activity; transcription coactivator activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
581
100
284
131
143
202
Cochlea GFP+ cells
104
136
154
176
147
NA
Utricle GFP- cells
164
111
121
102
159
110
Cochlea GFP- cells
150
192
178
147
143
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
143
GFP+
196
1.37
0.971
Utricle
184
Cochlea
153
0.83
1
Embryonic
192
Postnatal
157
0.82
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17444506 60.40 ± 0.61 57.00 ± 2.29 [59.96] 0.94 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
11530
11543
12600
10935
No bFGF
11765
12504
13045
11019
EGF
4340
4312
4727
4459
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
10935
No bFGF
11019
1.01
1
bFGF
10935
EGF
4459
0.41
2.12e-25
No bFGF
11019
EGF
4459
0.40
9.6e-26
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000005678
Symbol TRRAP
Description Transformation/transcription domain-associated protein
log10 riBAQ in stereocilia (mean ± sd) -5.43 ± ND
log10 riBAQ in utricle (mean ± sd) -5.09 ± 0.16
Molecules per stereocilium (mean ± error with slope error) 5.47 ± ND
Corrected Molecules per stereocilium (mean ± sd) 3.18 ± ND
Stereocilium / Utricle ratio (mean ± sd) 0.46 ± ND
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
No probes available for Trrap on Affymetrix MOE430_2.0 GeneChip.