MOUSE GENE INFORMATION [PubMed]
| Description | transmembrane inner ear | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Synonyms | 5131400L21Rik; Mm.87012 | ||||||||||||||||
| Chromosome | 9 | ||||||||||||||||
| Genetic Map Distance | 60.79 cM | ||||||||||||||||
| RefSeq Accessions | NM_146260; NP_666372 | ||||||||||||||||
| NCBI Entrez Gene | 20776 at chr9:110768550-110782587 (mm9) / chr9:110865707-110880083 (mm10) | ||||||||||||||||
| Ensembl Gene | ENSMUSG00000049555 | ||||||||||||||||
| VEGA Gene | OTTMUSG00000021713 | ||||||||||||||||
| MGI Gene | MGI:2159400 | ||||||||||||||||
| Mouse Protein (3) |
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| Pfam Domains | Pfam-B_10463; Herpes_gE; WBP-1 | ||||||||||||||||
| Mouse alleles (5) |
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| Human Homolog | TMIE (transmembrane inner ear) | ||||||||||||||||
| Human synonyms | DFNB6 | ||||||||||||||||
| Human cytoband | 3p21 | ||||||||||||||||
| Known deafness gene | DFNB6 | ||||||||||||||||
| Within mapped deafness loci | No | ||||||||||||||||
| Associated Human Disease in OMIM | |||||||||||||||||
| Chicken homolog (2) |
ENSGALG00000005443 (TMIE) encoding ENSGALP00000008725
ENSGALG00000005443 (TMIE) encoding ENSGALP00000038344
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Gene Ontology
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FACS-Sorted Hair Cells
Data |
Chart
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
|
|---|---|---|---|---|---|---|
Utricle GFP+ cells |
30 |
13 |
8 |
92 |
90 |
52 |
Cochlea GFP+ cells |
22 |
8 |
57 |
122 |
112 |
NA |
Utricle GFP- cells |
1 |
7 |
0 |
9 |
5 |
0 |
Cochlea GFP- cells |
1 |
0 |
2 |
2 |
3 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
GFP- |
3 |
GFP+ |
55 |
17.32 |
0.00106 |
Utricle |
26 |
Cochlea |
33 |
1.28 |
1 |
Embryonic |
10 |
Postnatal |
40 |
3.74 |
0.12 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID | IHC (mean ± sd) | OHC (mean ± sd) [OHC replicate] | Fold Change (OHC/IHC) | False Discovery Rate (FDR) |
|---|---|---|---|---|
| 17531671 | 39.58 ± 1.77 | 102.57 ± 23.04 [54.80] | 2.59 | 0.0994 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
|---|---|---|---|---|
bFGF |
80 |
84 |
66 |
57 |
No bFGF |
112 |
99 |
98 |
82 |
EGF |
49 |
42 |
50 |
47 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
bFGF |
57 |
No bFGF |
82 |
1.43 |
1 |
bFGF |
57 |
EGF |
47 |
0.82 |
0.407 |
No bFGF |
82 |
EGF |
47 |
0.57 |
0.00528 |
Chicken Stereocilium Proteomics
| The chicken protein was not reproducibly detected in the chicken stereocilia. |
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1441926_x_at
| Age | E12 | E13 | E16 | P0 | P6 | P15 |
|---|---|---|---|---|---|---|
| Spiral ganglion | ||||||
| Replicate 1 | 640.33 | 186.43 | 255.71 | 106.04 | 235.63 | 301.92 |
| Replicate 1 Call | P | A | A | A | A | A |
| Replicate 2 | 637.33 | 195.34 | 304.01 | 81.5 | 154.83 | 690 |
| Replicate 2 Call | P | A | A | A | A | A |
| Replicate 3 | 754.31 | 244.69 | 373.02 | 120.24 | 582.19 | 271.24 |
| Replicate 3 Call | P | P | P | A | A | A |
| Replicate 4 | 336.52 | 94.46 | 433.85 | 237.83 | ||
| Replicate 4 Call | A | A | A | A | ||
| Mean | 677.32 | 208.82 | 317.32 | 100.56 | 351.63 | 375.25 |
| Standard Deviation | 66.69 | 31.38 | 49.81 | 16.51 | 193.31 | 211.46 |
| Log2 Mean | 9.4 | 7.7 | 8.3 | 6.64 | 8.28 | 8.41 |
| Log2 Standard Deviation | 0.14 | 0.21 | 0.23 | 0.24 | 0.86 | 0.69 |
| Vestibular ganglion | ||||||
| Replicate 1 | 442 | 684.06 | 190.39 | 222.59 | 94.65 | 170.82 |
| Replicate 1 Call | P | P | A | A | A | A |
| Replicate 2 | 419.19 | 723.99 | 319.88 | 145.26 | 336.13 | 136.37 |
| Replicate 2 Call | P | P | A | A | A | A |
| Replicate 3 | 408.4 | 570.67 | 132.09 | 185.25 | 187.73 | 89.77 |
| Replicate 3 Call | P | P | A | A | A | A |
| Mean | 423.2 | 659.57 | 214.12 | 184.37 | 206.17 | 132.32 |
| Standard Deviation | 17.15 | 79.54 | 96.12 | 38.67 | 121.79 | 40.68 |
| Log2 Mean | 8.72 | 9.36 | 7.65 | 7.5 | 7.5 | 7 |
| Log2 Standard Deviation | 0.06 | 0.18 | 0.64 | 0.31 | 0.92 | 0.47 |
Probe set ID: 1443964_at
| Age | E12 | E13 | E16 | P0 | P6 | P15 |
|---|---|---|---|---|---|---|
| Spiral ganglion | ||||||
| Replicate 1 | 77.12 | 64.55 | 53.88 | 21.09 | 81.48 | 67.29 |
| Replicate 1 Call | A | A | A | A | A | A |
| Replicate 2 | 78.85 | 51.81 | 49.97 | 16.48 | 33.79 | 406.74 |
| Replicate 2 Call | A | A | A | A | A | P |
| Replicate 3 | 76.07 | 68.04 | 149.76 | 36.36 | 196.48 | 91.31 |
| Replicate 3 Call | A | A | P | A | A | A |
| Replicate 4 | 30.33 | 27.52 | 144.3 | 83.37 | ||
| Replicate 4 Call | A | A | M | A | ||
| Mean | 77.35 | 61.47 | 70.99 | 25.36 | 114.01 | 162.18 |
| Standard Deviation | 1.4 | 8.54 | 53.52 | 8.62 | 71.21 | 163.35 |
| Log2 Mean | 6.27 | 5.93 | 5.89 | 4.6 | 6.55 | 6.91 |
| Log2 Standard Deviation | 0.03 | 0.21 | 0.97 | 0.49 | 1.12 | 1.19 |
| Vestibular ganglion | ||||||
| Replicate 1 | 56.71 | 174.17 | 25.25 | 32.72 | 35.75 | 42.27 |
| Replicate 1 Call | A | P | A | A | A | A |
| Replicate 2 | 48.07 | 159.26 | 56.39 | 49.05 | 36.28 | 38.98 |
| Replicate 2 Call | A | P | A | A | A | A |
| Replicate 3 | 53.57 | 157.66 | 40.28 | 85.88 | 65.65 | 44.7 |
| Replicate 3 Call | A | P | A | A | A | A |
| Mean | 52.78 | 163.7 | 40.64 | 55.88 | 45.89 | 41.98 |
| Standard Deviation | 4.37 | 9.11 | 15.57 | 27.23 | 17.11 | 2.87 |
| Log2 Mean | 5.72 | 7.35 | 5.27 | 5.69 | 5.46 | 5.39 |
| Log2 Standard Deviation | 0.12 | 0.08 | 0.58 | 0.7 | 0.5 | 0.1 |