GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description transmembrane channel-like gene family 1
Synonyms Bth; 4933416G09Rik; Beethoven
Chromosome 19
Genetic Map Distance 13.98 cM
RefSeq Accessions NM_028953; NP_083229
NCBI Entrez Gene 13409 at chr19:20857948-21028692 (mm9) / chr19:20783456-21037151 (mm10)
Ensembl Gene ENSMUSG00000024749
VEGA Gene
MGI Gene MGI:2151016
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q8R4P5 Transmembrane channel-like protein 1 757 6
Q8C5T3 Putative uncharacterized protein 152 2
Q8CCC1 Putative uncharacterized protein (Fragment) 131 1
Pfam Domains Pfam-B_2472; Pfam-B_427; TMC; DUF843
Mouse alleles (2)
Allele Name Allele Type
Tmc1Bth Chemically induced (ENU)
Tmc1dn Spontaneous
Human Homolog TMC1 (transmembrane channel-like 1)
Human synonyms DFNA36; DFNB11; DFNB7
Human cytoband 9q21.12
Known deafness gene DFNB7/DFNB11/DFNA36
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000015145 (Q5YCC9_CHICK) encoding ENSGALP00000024394
Gene Ontology
Biological Process (1) sensory perception of sound
Cellular Component (3) integral to membrane; integral to membrane; membrane
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
160
331
708
2660
4733
4039
Cochlea GFP+ cells
104
44
472
7745
18727
NA
Utricle GFP- cells
10
48
23
9
25
582
Cochlea GFP- cells
6
14
21
31
37
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
73
GFP+
3611
48.95
1.39e-16
Utricle
1111
Cochlea
2720
2.45
0.935
Embryonic
90
Postnatal
2844
31.57
4.24e-10
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17363445 266.41 ± 53.00 489.01 ± 83.29 [326.77] 1.84 0.379
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
26
28
28
20
No bFGF
31
32
26
35
EGF
81
71
62
71
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
20
No bFGF
35
1.73
1
bFGF
20
EGF
71
3.46
1.81e-6
No bFGF
35
EGF
71
2.00
0.00231
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1421625_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 21.86 11.14 10.58 21.8 28.42 14.75
Replicate 1 Call A A A A A A
Replicate 2 23.26 14.49 10.84 11.4 7.82 23.75
Replicate 2 Call A A A A A A
Replicate 3 20.59 12.89 14.21 24.94 13.33 9.34
Replicate 3 Call A A A A A A
Replicate 4 17.99 18.29 23.58 14.74
Replicate 4 Call A A A A
Mean 21.9 12.84 13.41 19.11 18.29 15.65
Standard Deviation 1.34 1.68 3.48 5.81 9.4 5.97
Log2 Mean 4.45 3.67 3.71 4.2 4.02 3.89
Log2 Standard Deviation 0.09 0.19 0.36 0.49 0.84 0.55
 
Vestibular ganglion
Replicate 1 24.64 16.65 4.96 9.66 13.08 12.52
Replicate 1 Call A A A A A P
Replicate 2 20.22 8.3 16.83 10.63 23.59 16.18
Replicate 2 Call A A A A A A
Replicate 3 15.81 11.46 20.73 18.42 14.79 8.83
Replicate 3 Call A A A A A A
Mean 20.22 12.14 14.17 12.9 17.15 12.51
Standard Deviation 4.42 4.22 8.21 4.8 5.64 3.68
Log2 Mean 4.31 3.54 3.59 3.63 4.05 3.6
Log2 Standard Deviation 0.32 0.5 1.11 0.5 0.45 0.44
Probe set ID: 1421626_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 155.61 126.33 157.73 189.35 137.37 165.75
Replicate 1 Call A A A A A A
Replicate 2 153.42 142.29 171.72 148.21 146.68 149.74
Replicate 2 Call A A A A A A
Replicate 3 159.06 114.97 141.94 207.32 203.73 176
Replicate 3 Call A A A A A A
Replicate 4 136.55 185.96 133.77 153.3
Replicate 4 Call A A A A
Mean 156.03 127.86 151.99 182.71 155.39 161.2
Standard Deviation 2.84 13.72 15.93 24.84 32.68 12.02
Log2 Mean 7.29 6.99 7.24 7.5 7.26 7.33
Log2 Standard Deviation 0.03 0.15 0.15 0.21 0.28 0.11
 
Vestibular ganglion
Replicate 1 167.03 142.88 182.73 154.39 176.15 120.77
Replicate 1 Call A A A A A A
Replicate 2 183.25 144.68 131.92 170.99 150.22 148.97
Replicate 2 Call A A A A A A
Replicate 3 160.35 148.64 169.43 171.71 144.59 140.01
Replicate 3 Call A A A A A A
Mean 170.21 145.4 161.36 165.7 156.99 136.58
Standard Deviation 11.78 2.95 26.35 9.8 16.83 14.41
Log2 Mean 7.41 7.18 7.32 7.37 7.29 7.09
Log2 Standard Deviation 0.1 0.03 0.25 0.09 0.15 0.16