MOUSE GENE INFORMATION [
PubMed]
| Description |
transcription factor AP-2, alpha |
| Synonyms |
Ap2tf; Ap2; AP-2 alpha; Ap-2 (a); Tcfap2a; AP2alpha |
| Chromosome |
13 |
| Genetic Map Distance |
20.01 cM |
| RefSeq Accessions |
NM_001122948; NM_011547; NP_001116420; NP_035677 |
| NCBI Entrez Gene |
21418 at
chr13:40811044-40829192 (mm9)
/
chr13:40715302-40738239 (mm10)
|
| Ensembl Gene |
ENSMUSG00000021359
|
| VEGA Gene |
|
| MGI Gene |
MGI:104671
|
| Mouse Protein (4) |
| UniProt ID |
Description |
Length (AA) |
Predicted # TMs |
|
P34056
|
Transcription factor AP-2-alpha
|
437 |
0 |
|
Q3UL09
|
Putative uncharacterized protein
|
319 |
0 |
|
Q6LCW3
|
Transcription factor AP-2 isoform 2 (Fragment)
|
15 |
0 |
|
Q8BPN4
|
Putative uncharacterized protein
|
431 |
0 |
|
| Pfam Domains |
TF_AP-2 |
| Mouse alleles (7) |
|
| Human Homolog |
TFAP2A
(transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha))
|
| Human synonyms |
AP-2; AP-2alpha; AP2TF; BOFS; TFAP2
|
| Human cytoband |
6p24 |
| Known deafness gene |
No
|
| Within mapped deafness loci |
No
|
| Associated Human Disease in OMIM |
|
| Chicken homolog (1) |
ENSGALG00000012775 (O13111_CHICK) encoding ENSGALP00000020815
|
|
Gene Ontology
|
| Biological Process
(64) |
sensory perception of sound; positive regulation of bone mineralization; inner ear morphogenesis; neural tube closure; neural tube closure; positive regulation of neuron apoptosis; embryonic camera-type eye morphogenesis; regulation of cell differentiation; anterior neuropore closure; regulation of neuron differentiation; face morphogenesis; positive regulation of cell migration; lens morphogenesis in camera-type eye; embryonic body morphogenesis; lens morphogenesis in camera-type eye; negative regulation of epidermal growth factor receptor signaling pathway; lens induction in camera-type eye; epidermis morphogenesis; negative regulation of cell proliferation; negative regulation of cell proliferation; embryonic pattern specification; positive regulation of transcription; DNA-dependent; negative regulation of transcription by competitive promoter binding; positive regulation of transcription; DNA-dependent; eyelid development in camera-type eye; optic cup structural organization; optic vesicle morphogenesis; negative regulation of transcription; DNA-dependent; bone morphogenesis; palate development; positive regulation of tooth mineralization; positive regulation of transcription from RNA polymerase II promoter; oculomotor nerve formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; forelimb morphogenesis; positive regulation of transcription from RNA polymerase II promoter; transcription; DNA-dependent; embryonic cranial skeleton morphogenesis; embryonic cranial skeleton morphogenesis; skeletal system morphogenesis; embryonic forelimb morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; kidney development; regulation of transcription; DNA-dependent; regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; negative regulation of apoptotic process; negative regulation of apoptotic process; transcription from RNA polymerase II promoter; negative regulation of reactive oxygen species metabolic process; cornea development in camera-type eye; cellular response to iron ion; trigeminal nerve development; forebrain neuron development; positive regulation of gene expression; response to lipopolysaccharide; outflow tract morphogenesis; skin development; keratinocyte development; basement membrane organization; neural crest cell development |
| Cellular Component
(13) |
cytosol; intracellular membrane-bounded organelle; transcription factor complex; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; Golgi apparatus; centrosome; cytoplasm |
| Molecular Function
(31) |
transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; chromatin binding; chromatin binding; sequence-specific DNA binding; protein binding; sequence-specific DNA binding; protein binding; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription coactivator activity; protein dimerization activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding; core promoter proximal region sequence-specific DNA binding; core promoter proximal region sequence-specific DNA binding; RNA polymerase II transcription corepressor activity; RNA polymerase II transcription coactivator activity |
|
FACS-Sorted Hair Cells
|
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
Utricle GFP+ cells |
13 |
11 |
1 |
29 |
7 |
13 |
Cochlea GFP+ cells |
26 |
30 |
12 |
28 |
3 |
NA |
Utricle GFP- cells |
128 |
84 |
106 |
84 |
124 |
173 |
Cochlea GFP- cells |
209 |
122 |
286 |
110 |
37 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
GFP- |
133 |
GFP+ |
16 |
0.12 |
0.0575 |
Utricle |
64 |
Cochlea |
86 |
1.34 |
1 |
Embryonic |
78 |
Postnatal |
72 |
0.93 |
0.806 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID |
IHC (mean ± sd) |
OHC (mean ± sd) [OHC replicate] |
Fold Change (OHC/IHC) |
False Discovery Rate (FDR) |
| 17292011 |
3.79
±
0.49 |
5.23
±
0.85
[6.25]
|
1.38 |
0.501 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
bFGF |
1316 |
1267 |
1421 |
1006 |
No bFGF |
831 |
894 |
902 |
838 |
EGF |
518 |
507 |
512 |
512 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
bFGF |
1006 |
No bFGF |
838 |
0.83 |
1 |
bFGF |
1006 |
EGF |
512 |
0.51 |
1.16e-10 |
No bFGF |
838 |
EGF |
512 |
0.61 |
8.37e-6 |
Chicken Stereocilium Proteomics
| The chicken protein was not reproducibly detected in the chicken stereocilia. |
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1421995_at
| Age |
E12 |
E13 |
E16 |
P0 |
P6 |
P15 |
| Spiral ganglion |
| Replicate 1 |
111.23
|
116.59
|
104.84
|
138.19
|
115.72
|
130.97
|
| Replicate 1 Call |
A
|
P
|
P
|
A
|
A
|
A
|
| Replicate 2 |
122.43
|
114.44
|
150.92
|
153.06
|
132.35
|
124.19
|
| Replicate 2 Call |
A
|
P
|
P
|
A
|
A
|
A
|
| Replicate 3 |
116.87
|
117.32
|
138.83
|
166.22
|
116.9
|
113.03
|
| Replicate 3 Call |
A
|
P
|
P
|
A
|
A
|
A
|
| Replicate 4
|
|
|
134.14
|
134.08
|
150.61
|
122.2
|
| Replicate 4 Call |
|
|
A
|
A
|
A
|
A
|
| Mean |
116.84
|
116.12
|
132.18
|
147.89
|
128.9
|
122.6
|
| Standard Deviation |
5.6
|
1.5
|
19.55
|
14.69
|
16.34
|
7.4
|
| Log2 Mean |
6.87
|
6.86
|
7.03
|
7.2
|
7
|
6.94
|
| Log2 Standard Deviation |
0.07
|
0.02
|
0.23
|
0.14
|
0.18
|
0.09
|
| |
| Vestibular ganglion |
| Replicate 1 |
107.24
|
138.05
|
196.26
|
134.23
|
146.26
|
117.85
|
| Replicate 1 Call |
A
|
A
|
A
|
A
|
A
|
P
|
| Replicate 2 |
103.52
|
152.96
|
136.91
|
173.03
|
124.46
|
122.4
|
| Replicate 2 Call |
M
|
P
|
A
|
A
|
A
|
A
|
| Replicate 3 |
131.67
|
154.87
|
161.47
|
177.7
|
147.77
|
96.4
|
| Replicate 3 Call |
A
|
P
|
A
|
A
|
A
|
A
|
| Mean |
114.14
|
148.63
|
164.88
|
161.65
|
139.5
|
112.22
|
| Standard Deviation |
15.29
|
9.21
|
29.82
|
23.86
|
13.04
|
13.89
|
| Log2 Mean |
6.83
|
7.21
|
7.35
|
7.33
|
7.12
|
6.8
|
| Log2 Standard Deviation |
0.19
|
0.09
|
0.26
|
0.22
|
0.14
|
0.19
|
Probe set ID: 1421996_at
| Age |
E12 |
E13 |
E16 |
P0 |
P6 |
P15 |
| Spiral ganglion |
| Replicate 1 |
1381.22
|
1816.09
|
853.24
|
1078.75
|
380.75
|
815.24
|
| Replicate 1 Call |
P
|
P
|
P
|
P
|
A
|
P
|
| Replicate 2 |
1450.13
|
2034.57
|
745.9
|
701.61
|
560.98
|
452.68
|
| Replicate 2 Call |
P
|
P
|
P
|
A
|
P
|
A
|
| Replicate 3 |
1431.45
|
2103.15
|
683.36
|
657.81
|
355.92
|
551.59
|
| Replicate 3 Call |
P
|
P
|
P
|
A
|
A
|
A
|
| Replicate 4
|
|
|
772.93
|
593.12
|
415.73
|
664.7
|
| Replicate 4 Call |
|
|
A
|
A
|
A
|
A
|
| Mean |
1420.93
|
1984.6
|
763.86
|
757.82
|
428.35
|
621.05
|
| Standard Deviation |
35.64
|
149.91
|
70.41
|
218.54
|
91.76
|
155.77
|
| Log2 Mean |
10.47
|
10.95
|
9.57
|
9.53
|
8.72
|
9.24
|
| Log2 Standard Deviation |
0.04
|
0.11
|
0.13
|
0.38
|
0.29
|
0.36
|
| |
| Vestibular ganglion |
| Replicate 1 |
1567.76
|
1722.92
|
1017.95
|
787.05
|
460.72
|
596.23
|
| Replicate 1 Call |
P
|
P
|
P
|
P
|
A
|
P
|
| Replicate 2 |
1579.35
|
1754.36
|
1125.93
|
816.92
|
527.42
|
530.96
|
| Replicate 2 Call |
P
|
P
|
P
|
P
|
A
|
P
|
| Replicate 3 |
1533.44
|
1595.25
|
737.37
|
1492.11
|
607.54
|
504.15
|
| Replicate 3 Call |
P
|
P
|
P
|
P
|
M
|
P
|
| Mean |
1560.18
|
1690.84
|
960.42
|
1032.03
|
531.89
|
543.78
|
| Standard Deviation |
23.87
|
84.27
|
200.57
|
398.72
|
73.51
|
47.36
|
| Log2 Mean |
10.61
|
10.72
|
9.88
|
9.95
|
9.05
|
9.08
|
| Log2 Standard Deviation |
0.02
|
0.07
|
0.32
|
0.52
|
0.2
|
0.12
|
