MOUSE GENE INFORMATION [
PubMed]
| Description |
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| Synonyms |
Abcb3; Tap-2; HAM2; Ham-2; Ham2; MTP2; PSF2 |
| Chromosome |
17 |
| Genetic Map Distance |
17.98 cM |
| RefSeq Accessions |
NM_011530; NP_035660 |
| NCBI Entrez Gene |
21355 at
chr17:34341424-34353266 (mm9)
/
chr17:34204085-34216321 (mm10)
|
| Ensembl Gene |
ENSMUSG00000024339
|
| VEGA Gene |
OTTMUSG00000026436
|
| MGI Gene |
MGI:98484
|
| Mouse Protein (11) |
| UniProt ID |
Description |
Length (AA) |
Predicted # TMs |
|
P36371
|
Antigen peptide transporter 2
|
702 |
5 |
|
Q3TXM1
|
Putative uncharacterized protein
|
702 |
5 |
|
Q3UA79
|
Putative uncharacterized protein
|
701 |
5 |
|
Q61227
|
TAP2
|
703 |
5 |
|
Q61228
|
TAP2
|
703 |
5 |
|
Q61229
|
TAP2
|
703 |
5 |
|
Q61230
|
TAP2
|
703 |
5 |
|
Q792S7
|
Antigen processing transporter TAP2
|
702 |
5 |
|
Q80WF7
|
Tap2 protein
|
702 |
5 |
|
A6X8J6
|
Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (Fragment)
|
91 |
2 |
|
A6X8J5
|
Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (Fragment)
|
25 |
0 |
|
| Pfam Domains |
Pfam-B_3559; ABC_membrane; ABC_tran; Pfam-B_11559 |
| Mouse alleles (2) |
| Allele Name |
Allele Type |
|
Tap2jas
|
Chemically induced (ENU) |
|
Tap2m1Btlr
|
Chemically induced (ENU) |
|
| Human Homolog |
TAP2
(transporter 2, ATP-binding cassette, sub-family B (MDR/TAP))
|
| Human synonyms |
ABC18; ABCB3; APT2; D6S217E; PSF-2; PSF2; RING11
|
| Human cytoband |
6p21.3 |
| Known deafness gene |
No
|
| Within mapped deafness loci |
DFNA21; DFNA31; OTSC3 |
| Associated Human Disease in OMIM |
|
| Chicken homolog (1) |
ENSGALG00000000181 (A5HUM1_CHICK) encoding ENSGALP00000000236
|
|
Gene Ontology
|
| Biological Process
(32) |
transmembrane transport; transmembrane transport; transmembrane transport; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway; TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway; TAP-dependent; intracellular transport of viral proteins in host cell; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway; TAP-dependent; cytosol to ER transport; oligopeptide transmembrane transport; peptide antigen transport; protein complex assembly; protection from natural killer cell mediated cytotoxicity; positive regulation of T cell mediated cytotoxicity; ATP catabolic process; ATP catabolic process; ATP catabolic process; transport; metabolic process; transport; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of endogenous peptide antigen via MHC class I; protein transport; antigen processing and presentation of endogenous peptide antigen via MHC class I; peptide transport; peptide transport; peptide transport; peptide transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous protein antigen via MHC class Ib; TAP-dependent; response to molecule of bacterial origin |
| Cellular Component
(13) |
nucleus; endoplasmic reticulum; membrane; membrane; MHC class I peptide loading complex; plasma membrane; integral to membrane; integral to endoplasmic reticulum membrane; microsome; host cell; TAP complex; TAP complex; TAP complex |
| Molecular Function
(27) |
TAP1 binding; TAP1 binding; TAP1 binding; TAP1 binding; protein homodimerization activity; ADP binding; protein heterodimerization activity; transporter activity; MHC class I protein binding; protein binding; peptide antigen binding; peptide transporter activity; nucleotide binding; ATPase activity; coupled to transmembrane movement of substances; nucleoside-triphosphatase activity; ATPase activity; ATP binding; ATP binding; oligopeptide-transporting ATPase activity; peptide antigen binding; TAP2 binding; TAP2 binding; tapasin binding; tapasin binding; MHC class I protein binding; MHC class I protein binding; peptide antigen-transporting ATPase activity |
|
FACS-Sorted Hair Cells
|
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
Utricle GFP+ cells |
0 |
3 |
3 |
0 |
4 |
52 |
Cochlea GFP+ cells |
1 |
27 |
0 |
0 |
1 |
NA |
Utricle GFP- cells |
0 |
8 |
6 |
11 |
7 |
15 |
Cochlea GFP- cells |
2 |
2 |
18 |
10 |
45 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
GFP- |
11 |
GFP+ |
8 |
0.73 |
0.727 |
Utricle |
9 |
Cochlea |
11 |
1.17 |
1 |
Embryonic |
5 |
Postnatal |
12 |
2.18 |
0.93 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID |
IHC (mean ± sd) |
OHC (mean ± sd) [OHC replicate] |
Fold Change (OHC/IHC) |
False Discovery Rate (FDR) |
| 17336458 |
8.85
±
0.16 |
7.81
±
2.71
[13.63]
|
0.88 |
0.578 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
bFGF |
25 |
20 |
41 |
556 |
No bFGF |
16 |
25 |
24 |
26 |
EGF |
11 |
17 |
19 |
16 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
bFGF |
556 |
No bFGF |
26 |
0.05 |
4.5e-16 |
bFGF |
556 |
EGF |
16 |
0.03 |
3.23e-125 |
No bFGF |
26 |
EGF |
16 |
0.60 |
0.0723 |
Chicken Stereocilium Proteomics
| The chicken protein was not reproducibly detected in the chicken stereocilia. |
Auditory and Vestibular Ganglion Neurons
No probes available for Tap2 on Affymetrix MOE430_2.0 GeneChip.
