GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms TAP; Tap-1; Ham-1; MTP1; PSF-1; Abcb2; Ham1; RING4
Chromosome 17
Genetic Map Distance 17.98 cM
RefSeq Accessions NM_001161730; NM_013683; NP_001155202; NP_038711
NCBI Entrez Gene 21354 at chr17:34324501-34334170 (mm9) / chr17:34187556-34197225 (mm10)
Ensembl Gene ENSMUSG00000037321
VEGA Gene OTTMUSG00000036473
MGI Gene MGI:98483
Mouse Protein (10)
UniProt ID Description Length (AA) Predicted # TMs
P21958 Antigen peptide transporter 1 724 7
Q3TBA3 Putative uncharacterized protein 696 7
Q3U543 Putative uncharacterized protein 724 7
Q3U6V4 Putative uncharacterized protein 724 7
Q62427 Antigen processing transporter TAP1 724 7
Q62428 TAP1-f 724 7
Q62429 TAP1-k 724 7
Q78E61 TAP1-g7 724 7
Q5D0F3 Tap1 protein 577 3
Q9QWR3 Tap-1 protein (Fragment) 110 2
Pfam Domains Pfam-B_8254; Pfam-B_9348; Pfam-B_6424; ABC_membrane; ABC_tran; Pfam-B_11559
Mouse alleles (6)
Allele Name Allele Type
Tap1tm2e(EUCOMM)Hmgu EUCOMM-projects
Tap1tm2a(EUCOMM)Hmgu EUCOMM-projects
Tap1tm1e(EUCOMM)Hmgu EUCOMM-projects
Tap1rose Chemically induced (ENU)
Tap1tm1Arp Targeted (knock-out)
Tap1tm1Hpl Targeted (knock-out)
Human Homolog TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP))
Human synonyms ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1*0102N; TAP1N
Human cytoband 6p21.3
Known deafness gene No
Within mapped deafness loci DFNA21; DFNA31; OTSC3
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000019832 (B7FBL3_CHICK) encoding ENSGALP00000030874
Gene Ontology
Biological Process (16) peptide transport; peptide transport; protein transport; ATP catabolic process; ATP catabolic process; protection from natural killer cell mediated cytotoxicity; transport; transport; defense response; positive regulation of T cell mediated cytotoxicity; transmembrane transport; cytosol to ER transport; oligopeptide transmembrane transport; intracellular transport of viral proteins in host cell; antigen processing and presentation of endogenous peptide antigen via MHC class I; peptide transport
Cellular Component (12) microsome; mitochondrion; endoplasmic reticulum; membrane; membrane; TAP complex; TAP complex; TAP complex; host cell; plasma membrane; integral to membrane; integral to endoplasmic reticulum membrane
Molecular Function (24) nucleotide binding; ATPase activity; ATPase activity; coupled to transmembrane movement of substances; TAP1 binding; TAP1 binding; MHC class I protein binding; MHC class I protein binding; tapasin binding; tapasin binding; peptide antigen binding; TAP2 binding; TAP2 binding; TAP2 binding; ADP binding; ADP binding; protein homodimerization activity; protein heterodimerization activity; peptide antigen binding; oligopeptide-transporting ATPase activity; ATP binding; ATP binding; peptide transporter activity; transporter activity; nucleoside-triphosphatase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
8
32
10
2
4
32
Cochlea GFP+ cells
4
25
3
1
7
NA
Utricle GFP- cells
10
16
10
35
19
0
Cochlea GFP- cells
2
5
18
16
41
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
16
GFP+
12
0.75
0.775
Utricle
15
Cochlea
12
0.83
1
Embryonic
13
Postnatal
14
1.10
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17336432 14.78 ± 0.65 15.07 ± 0.77 [14.53] 1.02 0.859
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
10
20
20
388
No bFGF
27
18
22
40
EGF
3
7
7
6
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
388
No bFGF
40
0.10
7.81e-8
bFGF
388
EGF
6
0.02
2.0e-116
No bFGF
40
EGF
6
0.15
2.53e-12
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416016_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 235.92 96.18 109.19 84.53 155.73 97.12
Replicate 1 Call A A A A A M
Replicate 2 151.76 174.1 225.12 196.29 129.69 214.02
Replicate 2 Call A A A A A P
Replicate 3 133.33 278.27 158.21 123.5 186.39 137.55
Replicate 3 Call A A A A A A
Replicate 4 160.7 152.79 253.87 131.73
Replicate 4 Call P A A A
Mean 173.67 182.85 163.31 139.28 181.42 145.11
Standard Deviation 54.69 91.36 47.55 47.18 53.57 49.29
Log2 Mean 7.4 7.38 7.3 7.06 7.46 7.12
Log2 Standard Deviation 0.43 0.77 0.43 0.51 0.41 0.47
 
Vestibular ganglion
Replicate 1 165.24 185.06 116.24 135.7 365.97 262.3
Replicate 1 Call A A A A A P
Replicate 2 173.61 178.98 179.04 300.89 334.1 192.58
Replicate 2 Call A A A A A P
Replicate 3 190 198.51 264.1 254.48 309.08 330.5
Replicate 3 Call A P A A A P
Mean 176.28 187.52 186.46 230.36 336.38 261.79
Standard Deviation 12.59 9.99 74.21 85.2 28.51 68.96
Log2 Mean 7.46 7.55 7.46 7.77 8.39 8
Log2 Standard Deviation 0.1 0.08 0.59 0.61 0.12 0.39
Probe set ID: 1448177_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 5.7 9.56 24.59 13.98 2.11 30.46
Replicate 1 Call A A A A A A
Replicate 2 8.7 29.94 24.55 5.92 8.61 25
Replicate 2 Call A A A A A A
Replicate 3 13.14 3.42 1.15 16.17 26.33 38.79
Replicate 3 Call A A A A A A
Replicate 4 1.44 13.14 23.89 1
Replicate 4 Call A A A A
Mean 9.18 14.31 12.93 12.3 15.24 23.81
Standard Deviation 3.74 13.88 13.44 4.44 11.75 16.23
Log2 Mean 3.12 3.31 2.49 3.53 3.37 3.71
Log2 Standard Deviation 0.6 1.57 2.46 0.65 1.69 2.49
 
Vestibular ganglion
Replicate 1 17.98 23.19 14.68 30.33 8.33 8.29
Replicate 1 Call A A A A A A
Replicate 2 5.59 27.1 27.55 23.16 5.16 11.32
Replicate 2 Call A A A A A A
Replicate 3 19.52 13 30.96 19.2 14.25 11.41
Replicate 3 Call A A A A A A
Mean 14.36 21.1 24.4 24.23 9.25 10.34
Standard Deviation 7.64 7.28 8.59 5.64 4.61 1.78
Log2 Mean 3.65 4.33 4.54 4.57 3.09 3.35
Log2 Standard Deviation 1.01 0.56 0.58 0.33 0.73 0.26