GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description spectrin repeat containing, nuclear envelope family member 4
Synonyms 0610012K07Rik; nesprin-4; AI428936
Chromosome 7
Genetic Map Distance 17.39 cM
RefSeq Accessions NM_153577; NP_705805
NCBI Entrez Gene 233066 at chr7:31099835-31104064 (mm9) / chr7:30314399-30319046 (mm10)
Ensembl Gene ENSMUSG00000019737
VEGA Gene
MGI Gene MGI:2141950
Mouse Protein (1)
UniProt ID Description Length (AA) Predicted # TMs
Q8CII8 Nesprin-4 388 1
Pfam Domains Spectrin; KASH
Mouse alleles (2)
Allele Name Allele Type
AI428936tm1e(KOMP)Wtsi KOMP-CSD-Project
AI428936tm1a(KOMP)Wtsi KOMP-CSD-Project
Human Homolog C19orf46 (chromosome 19 open reading frame 46)
Human synonyms SYNE4
Human cytoband 19q13.12
Known deafness gene DFNB76
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (0)
Gene Ontology
Biological Process (1) establishment of epithelial cell apical/basal polarity
Cellular Component (5) nucleus; membrane; integral to membrane; integral to membrane; integral to nuclear outer membrane
Molecular Function (2) actin binding; protein binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
17
47
282
115
217
261
Cochlea GFP+ cells
8
33
277
293
347
NA
Utricle GFP- cells
22
18
6
5
17
0
Cochlea GFP- cells
10
13
56
15
4
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
15
GFP+
172
11.08
0.000156
Utricle
84
Cochlea
106
1.26
1
Embryonic
21
Postnatal
135
6.33
0.0292
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17476349 123.96 ± 10.60 161.03 ± 42.70 [67.74] 1.30 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
26
33
34
26
No bFGF
27
24
38
28
EGF
12
10
19
14
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
26
No bFGF
28
1.09
1
bFGF
26
EGF
14
0.54
0.0273
No bFGF
28
EGF
14
0.49
0.0123
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Syne4.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1427175_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 103.17 137.67 100.73 117.22 87.33 78.9
Replicate 1 Call A P P A A A
Replicate 2 104.86 140.54 152.51 105.63 98 175.55
Replicate 2 Call A P P A A A
Replicate 3 98.61 123.07 139.82 173.61 68.66 153.72
Replicate 3 Call A P P A A A
Replicate 4 112.78 156.15 123.71 116.29
Replicate 4 Call A A A A
Mean 102.21 133.76 126.46 138.15 94.43 131.12
Standard Deviation 3.23 9.37 23.85 32.03 22.98 42.55
Log2 Mean 6.67 7.06 6.96 7.08 6.53 6.97
Log2 Standard Deviation 0.05 0.1 0.28 0.34 0.35 0.51
 
Vestibular ganglion
Replicate 1 104.07 110.16 215.72 155.62 148.53 135.4
Replicate 1 Call A A A A A A
Replicate 2 95.35 110.05 172.46 137.24 137.37 144.23
Replicate 2 Call A P A A A P
Replicate 3 130.03 150.7 167.48 156.96 125.69 135.33
Replicate 3 Call A P A A A A
Mean 109.82 123.64 185.22 149.94 137.2 138.32
Standard Deviation 18.04 23.44 26.53 11.02 11.42 5.12
Log2 Mean 6.77 6.93 7.52 7.23 7.1 7.11
Log2 Standard Deviation 0.23 0.26 0.2 0.11 0.12 0.05
Probe set ID: 1427176_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1583.81 1493.75 2107.72 2442.23 1970.63 2357.78
Replicate 1 Call P P P P P P
Replicate 2 1526.03 1624.03 2948.45 2444.6 2166.05 2739.6
Replicate 2 Call P P P P P P
Replicate 3 1519.6 1548.38 2581.86 2699.41 1810.1 2399.17
Replicate 3 Call P P P P P P
Replicate 4 3239.48 2206.37 1747.76 2435.19
Replicate 4 Call P P P P
Mean 1543.15 1555.39 2719.38 2448.15 1923.64 2482.94
Standard Deviation 35.36 65.42 488.54 201.36 186.9 174.01
Log2 Mean 10.59 10.6 11.39 11.25 10.9 11.28
Log2 Standard Deviation 0.03 0.06 0.27 0.12 0.14 0.1
 
Vestibular ganglion
Replicate 1 1738.27 1803.92 2143.04 2074.89 1789.41 1658.27
Replicate 1 Call P P P P P P
Replicate 2 1715.09 1691.79 1718.38 1982.86 1744.98 1607.65
Replicate 2 Call P P P P P P
Replicate 3 1849.72 1776.6 1704.03 1973.59 1778.66 1568.94
Replicate 3 Call P P P P P P
Mean 1767.69 1757.44 1855.15 2010.45 1771.02 1611.62
Standard Deviation 71.98 58.47 249.42 56 23.18 44.8
Log2 Mean 10.79 10.78 10.85 10.97 10.79 10.65
Log2 Standard Deviation 0.06 0.05 0.19 0.04 0.02 0.04