GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description spermatogenesis associated 5
Synonyms 2510048F20Rik; Spaf; C78064
Chromosome 3
Genetic Map Distance 18.46 cM
RefSeq Accessions NM_001163511; NM_021343; NP_001156983; NP_067318
NCBI Entrez Gene 57815 at chr3:37319202-37478017 (mm9) / chr3:37420280-37579096 (mm10)
Ensembl Gene ENSMUSG00000027722
VEGA Gene OTTMUSG00000007434
MGI Gene MGI:1927170
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
Q3UMC0 Spermatogenesis-associated protein 5 893 0
B7ZNK9 Spata5 protein 893 0
Q8CH38 SPAF (Fragment) 53 0
Q9Z2U6 SPAF (Fragment) 79 0
Pfam Domains CDC48_N; Pfam-B_284; AAA; AAA
Mouse alleles (2)
Allele Name Allele Type
Spata5tm1a(KOMP)Wtsi KOMP-CSD-Project
Spata5tm1e(KOMP)Wtsi KOMP-CSD-Project
Human Homolog SPATA5 (spermatogenesis associated 5)
Human synonyms AFG2; SPAF
Human cytoband 4q28.1
Known deafness gene No
Within mapped deafness loci DFNA52
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000011833 (SPATA5) encoding ENSGALP00000019284
Gene Ontology
Biological Process (4) cell differentiation; spermatogenesis; multicellular organismal development; metabolic process
Cellular Component (2) mitochondrion; cytoplasm
Molecular Function (6) nucleoside-triphosphatase activity; binding; nucleotide binding; nucleotide binding; ATP binding; ATP binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
56
32
15
49
43
6
Cochlea GFP+ cells
38
40
42
58
74
NA
Utricle GFP- cells
64
24
38
19
47
0
Cochlea GFP- cells
65
96
61
37
48
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
45
GFP+
41
0.91
1
Utricle
33
Cochlea
56
1.69
1
Embryonic
52
Postnatal
38
0.74
0.988
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17397142 37.66 ± 0.69 41.86 ± 7.70 [26.38] 1.11 0.563
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
691
631
580
619
No bFGF
412
401
322
362
EGF
670
675
564
636
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
619
No bFGF
362
0.59
0.544
bFGF
619
EGF
636
1.03
0.899
No bFGF
362
EGF
636
1.75
9.33e-6
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1417254_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 920.83 1008.42 800.21 548.06 635.55 289.24
Replicate 1 Call P P P P P P
Replicate 2 1016.33 1036.84 451.94 550.04 591.64 436.12
Replicate 2 Call P P P P P P
Replicate 3 1080.48 1173.52 774.65 464.57 993.2 236.16
Replicate 3 Call P P P P P P
Replicate 4 403.21 669.84 415.73 272.67
Replicate 4 Call P P P P
Mean 1005.88 1072.93 607.5 558.13 659.03 308.55
Standard Deviation 80.34 88.27 208.97 84.46 242.18 87.89
Log2 Mean 9.97 10.06 9.18 9.11 9.29 8.23
Log2 Standard Deviation 0.12 0.12 0.51 0.22 0.52 0.38
 
Vestibular ganglion
Replicate 1 983.9 1111.5 1037.98 1098.8 1004.27 706.02
Replicate 1 Call P P P P P P
Replicate 2 949.75 1191.69 1066.55 883.47 1032.74 980.18
Replicate 2 Call P P P P P P
Replicate 3 851.83 1108.12 1135.56 1004.27 1200.51 1073.15
Replicate 3 Call P P P P P P
Mean 928.49 1137.1 1080.03 995.51 1079.17 919.78
Standard Deviation 68.55 47.3 50.17 107.93 106.04 190.87
Log2 Mean 9.86 10.15 10.08 9.95 10.07 9.82
Log2 Standard Deviation 0.11 0.06 0.07 0.16 0.14 0.32
Probe set ID: 1438844_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 457.4 691.04 528.47 518.98 499.46 250.36
Replicate 1 Call P P P P P P
Replicate 2 494.62 538.05 538.58 414.92 514.9 461.26
Replicate 2 Call P P P P P P
Replicate 3 550.56 566.22 710.53 418.18 682.82 198.66
Replicate 3 Call P P P P P A
Replicate 4 442.55 521.18 565.69 459.79
Replicate 4 Call P P P P
Mean 500.86 598.44 555.03 468.32 565.72 342.52
Standard Deviation 46.89 81.42 112.26 59.79 83.04 137.89
Log2 Mean 8.96 9.22 9.1 8.86 9.13 8.32
Log2 Standard Deviation 0.13 0.19 0.28 0.18 0.2 0.62
 
Vestibular ganglion
Replicate 1 456.23 567.09 620 607.64 743.11 413.27
Replicate 1 Call P P P P P P
Replicate 2 515.03 590.57 659.98 622.19 563.34 700.34
Replicate 2 Call P P P P P P
Replicate 3 442.59 615.88 715.84 696.52 762.79 660.3
Replicate 3 Call P P P P P P
Mean 471.28 591.18 665.27 642.12 689.75 591.3
Standard Deviation 38.49 24.4 48.14 47.67 109.91 155.48
Log2 Mean 8.88 9.21 9.38 9.32 9.42 9.17
Log2 Standard Deviation 0.12 0.06 0.1 0.11 0.24 0.42
Probe set ID: 1448639_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 657.08 689.6 667.32 527.21 512.97 408.91
Replicate 1 Call M P P P P A
Replicate 2 731.25 726.6 515.29 517.34 578.89 371.31
Replicate 2 Call P P P P P A
Replicate 3 696.52 751.56 747.96 462.63 722.66 324.14
Replicate 3 Call P P P P P A
Replicate 4 459.62 622.95 414.33 284.26
Replicate 4 Call P P P A
Mean 694.95 722.59 597.55 532.53 557.21 347.16
Standard Deviation 37.11 31.17 133.27 66.64 129.38 54.41
Log2 Mean 9.44 9.5 9.2 9.05 9.09 8.43
Log2 Standard Deviation 0.08 0.06 0.32 0.18 0.34 0.23
 
Vestibular ganglion
Replicate 1 664.25 793.56 662.25 745.77 720.1 469.03
Replicate 1 Call P P P P P P
Replicate 2 653.17 841.68 589.46 641.14 694.86 628.27
Replicate 2 Call P P P P P P
Replicate 3 653.9 773.3 722.24 739.43 823.57 682.41
Replicate 3 Call P P P P P P
Mean 657.11 802.85 657.98 708.78 746.18 593.24
Standard Deviation 6.2 35.12 66.49 58.66 68.2 110.92
Log2 Mean 9.36 9.65 9.36 9.47 9.54 9.19
Log2 Standard Deviation 0.01 0.06 0.15 0.12 0.13 0.28