GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description SRY (sex determining region Y)-box 5
Synonyms A730017D01Rik
Chromosome 6
Genetic Map Distance 76.14 cM
RefSeq Accessions NM_001113559; NM_001243163; NM_011444; NP_001107031; NP_001230092; NP_035574; XR_105064; XR_107856
NCBI Entrez Gene 20678 at chr6:143781349-144158078 (mm9) / chr6:143828425-144210969 (mm10)
Ensembl Gene ENSMUSG00000041540
VEGA Gene OTTMUSG00000025246
MGI Gene MGI:98367
Mouse Protein (10)
UniProt ID Description Length (AA) Predicted # TMs
P35710 Transcription factor SOX-5 763 0
B2KFM4 SRY-box containing gene 5 679 0
B2KFM6 SRY-box containing gene 5 234 0
B2KFM7 SRY-box containing gene 5 (Fragment) 184 0
B2KFM8 SRY-box containing gene 5 (Fragment) 214 0
B2KFM9 SRY-box containing gene 5 763 0
Q2TBA9 SRY-box containing gene 5 715 0
Q3TVF9 Putative uncharacterized protein 392 0
Q3V1Q6 Putative uncharacterized protein 293 0
Q8C4K8 Putative uncharacterized protein 346 0
Pfam Domains Pfam-B_898; Pfam-B_3553; HemX; HMG_box
Mouse alleles (5)
Allele Name Allele Type
Sox5tm1a(EUCOMM)Hmgu EUCOMM-projects
Sox5tm1Vlf Targeted (Reporter)
Sox5tm2.1Vlf Targeted (knock-out)
Sox5tm2Vlf Targeted (Floxed/Frt)
Sox5Tn(sb-lacZ,GFP)IF2.1Jtak Transposon induced
Human Homolog SOX5 (SRY (sex determining region Y)-box 5)
Human synonyms L-SOX5
Human cytoband 12p12.1
Known deafness gene No
Within mapped deafness loci DFNB62
Associated Human Disease in OMIM
None
Chicken homolog (3)
ENSGALG00000013204 (Q6A2A8_CHICK) encoding ENSGALP00000021536
ENSGALG00000013204 (Q6A2A8_CHICK) encoding ENSGALP00000036615
ENSGALG00000013204 (Q6A2A8_CHICK) encoding ENSGALP00000036617
Gene Ontology
Biological Process (16) positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; oligodendrocyte differentiation; cell fate commitment; cartilage development; positive regulation of chondrocyte differentiation; positive regulation of chondrocyte differentiation; positive regulation of cartilage development; cellular response to transforming growth factor beta stimulus; positive regulation of mesenchymal stem cell differentiation; central nervous system neuron differentiation; regulation of timing of neuron differentiation; regulation of transcription; DNA-dependent; transcription; DNA-dependent; in utero embryonic development; negative regulation of transcription; DNA-dependent
Cellular Component (2) nucleus; nucleus
Molecular Function (7) sequence-specific DNA binding transcription factor activity; protein binding; transcription regulatory region DNA binding; transcription regulatory region DNA binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding transcription factor activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
0
6
4
3
45
Cochlea GFP+ cells
8
7
2
1
1
NA
Utricle GFP- cells
18
15
10
13
12
0
Cochlea GFP- cells
9
21
18
9
14
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
13
GFP+
7
0.59
0.627
Utricle
11
Cochlea
9
0.83
1
Embryonic
10
Postnatal
10
0.98
0.965
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17472641 25.83 ± 2.25 24.19 ± 0.97 [21.97] 0.94 0.615
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
477
484
548
392
No bFGF
1025
1117
1133
844
EGF
298
286
335
307
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
392
No bFGF
844
2.15
0.526
bFGF
392
EGF
307
0.78
0.0701
No bFGF
844
EGF
307
0.36
5.7e-21
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1423500_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 141.61 37.33 41.76 98.63 74.58 203.75
Replicate 1 Call P A P P P A
Replicate 2 161.48 46.92 70.58 118.91 57.82 160.8
Replicate 2 Call P P A A A P
Replicate 3 166.65 93.17 84.74 6.38 317.63 45.24
Replicate 3 Call P P A A P P
Replicate 4 119.44 4.55 407.26 87.85
Replicate 4 Call A A M A
Mean 156.58 59.14 79.13 57.12 214.32 124.41
Standard Deviation 13.22 29.86 32.28 60.22 175.04 71.24
Log2 Mean 7.29 5.77 6.21 4.59 7.26 6.74
Log2 Standard Deviation 0.12 0.69 0.63 2.51 1.43 0.97
 
Vestibular ganglion
Replicate 1 210.04 141.24 74.37 7.15 3.95 22.4
Replicate 1 Call P P P A A P
Replicate 2 276.73 163.05 76.66 37.15 44.25 20.7
Replicate 2 Call P P A A A A
Replicate 3 295.6 150.69 15.66 60.59 42.79 31.08
Replicate 3 Call P P A A A P
Mean 260.79 151.66 55.56 34.96 30.33 24.73
Standard Deviation 44.95 10.94 34.58 26.79 22.86 5.57
Log2 Mean 8.01 7.24 5.48 4.66 4.29 4.6
Log2 Standard Deviation 0.26 0.1 1.31 1.62 2 0.31
Probe set ID: 1432189_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 8.89 9.15 32.12 43.94 76.93 46.19
Replicate 1 Call A A A A A A
Replicate 2 27.9 22.68 46.21 40.5 48.94 89.66
Replicate 2 Call A A A A A A
Replicate 3 24.25 31.48 64.68 56.39 51.78 55.69
Replicate 3 Call A A A A A A
Replicate 4 89.14 37.42 79.5 55.88
Replicate 4 Call A A A A
Mean 20.35 21.1 58.04 44.56 64.29 61.86
Standard Deviation 10.09 11.25 24.65 8.32 16.16 19.08
Log2 Mean 4.18 4.22 5.76 5.46 5.97 5.9
Log2 Standard Deviation 0.9 0.92 0.63 0.26 0.37 0.41
 
Vestibular ganglion
Replicate 1 14.1 36.32 35.04 41.43 56.83 20.76
Replicate 1 Call A A A A A A
Replicate 2 42.24 36.82 44.34 43.83 29.97 8.9
Replicate 2 Call A A A A A A
Replicate 3 28.34 25.76 44.47 59.85 29.39 12.99
Replicate 3 Call A A A A A A
Mean 28.23 32.97 41.28 48.37 38.73 14.22
Standard Deviation 14.07 6.25 5.41 10.01 15.68 6.02
Log2 Mean 4.68 5.02 5.36 5.58 5.2 3.74
Log2 Standard Deviation 0.8 0.29 0.2 0.29 0.54 0.61
Probe set ID: 1432190_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 138.15 221.41 115.58 138.33 129.2 102.16
Replicate 1 Call A A A A A A
Replicate 2 155.02 210.93 96.64 202.41 92.77 124.43
Replicate 2 Call A A A A A A
Replicate 3 155.09 160.79 85.53 126.55 126.51 52.43
Replicate 3 Call A A A A A A
Replicate 4 92.57 122.96 182.34 69.43
Replicate 4 Call A A A A
Mean 149.42 197.71 97.58 147.56 132.71 87.11
Standard Deviation 9.76 32.4 12.85 37.15 37.01 32.32
Log2 Mean 7.22 7.61 6.6 7.17 7.01 6.37
Log2 Standard Deviation 0.1 0.25 0.18 0.33 0.4 0.56
 
Vestibular ganglion
Replicate 1 105.34 108.49 144.72 261.59 173.03 180.55
Replicate 1 Call A A A A A A
Replicate 2 144.99 145.28 242.15 276.19 190.16 123.38
Replicate 2 Call A A A A A A
Replicate 3 112.41 127.1 229.78 187.57 171.53 145.08
Replicate 3 Call A A A A A A
Mean 120.91 126.96 205.55 241.78 178.24 149.67
Standard Deviation 21.15 18.4 53.04 47.51 10.35 28.86
Log2 Mean 6.9 6.98 7.65 7.9 7.48 7.21
Log2 Standard Deviation 0.24 0.21 0.41 0.3 0.08 0.28
Probe set ID: 1440827_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 139.43 80.91 44.4 83.01 63.22 94.24
Replicate 1 Call P A P A P P
Replicate 2 138.37 84.71 81.07 120.54 52.2 121.31
Replicate 2 Call P P P P A P
Replicate 3 122.58 104.46 79.62 26.3 251.01 43.33
Replicate 3 Call P P P A P A
Replicate 4 83.32 37.01 312.49 73.42
Replicate 4 Call P A P A
Mean 133.46 90.03 72.1 66.72 169.73 83.08
Standard Deviation 9.44 12.64 18.53 43.51 131.84 32.96
Log2 Mean 7.06 6.48 6.13 5.8 6.99 6.28
Log2 Standard Deviation 0.1 0.2 0.44 1.02 1.33 0.63
 
Vestibular ganglion
Replicate 1 193.57 128.57 82.1 27.31 52.59 42.97
Replicate 1 Call P P A A A A
Replicate 2 224.8 151.24 95.83 106.08 75.62 42.68
Replicate 2 Call P P A M P P
Replicate 3 189.32 156.09 94.34 106.3 59.6 36.54
Replicate 3 Call P P A P A A
Mean 202.56 145.3 90.76 79.9 62.6 40.73
Standard Deviation 19.37 14.69 7.53 45.54 11.81 3.63
Log2 Mean 7.66 7.18 6.5 6.08 5.95 5.34
Log2 Standard Deviation 0.13 0.15 0.12 1.13 0.27 0.13
Probe set ID: 1452511_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 100.93 64.08 74.73 61.86 65.09 80.5
Replicate 1 Call A A A A A A
Replicate 2 82.52 88.78 86.95 88.42 72.63 67.24
Replicate 2 Call A A A A A A
Replicate 3 101.55 113.4 85.22 103.66 69.65 68.62
Replicate 3 Call A A A A A A
Replicate 4 65.37 98.02 69.3 70.79
Replicate 4 Call A A A A
Mean 95 88.75 78.07 87.99 69.17 71.79
Standard Deviation 10.81 24.66 10.04 18.52 3.1 5.99
Log2 Mean 6.56 6.43 6.28 6.43 6.11 6.16
Log2 Standard Deviation 0.17 0.41 0.19 0.33 0.07 0.12
 
Vestibular ganglion
Replicate 1 135.47 91.63 108.3 79.31 87.26 112.85
Replicate 1 Call A A A A A A
Replicate 2 133.57 80.09 97.62 88.5 93.95 100.63
Replicate 2 Call A P A A A A
Replicate 3 113.35 104.43 74.05 81.51 83.64 108.52
Replicate 3 Call A A A A A A
Mean 127.46 92.05 93.32 83.11 88.28 107.33
Standard Deviation 12.26 12.18 17.52 4.8 5.23 6.2
Log2 Mean 6.99 6.52 6.53 6.38 6.46 6.74
Log2 Standard Deviation 0.14 0.19 0.28 0.08 0.08 0.08
Probe set ID: 1459261_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1 25.49 14.52 21.55 18.92 23.6
Replicate 1 Call A A A A A A
Replicate 2 21.83 16.09 6.12 28.16 29.47 8.54
Replicate 2 Call A A A A A A
Replicate 3 10.49 26.11 11.43 21.95 10.45 19.02
Replicate 3 Call A P A A A A
Replicate 4 15.12 26.31 12.43 9.98
Replicate 4 Call A A A A
Mean 11.11 22.56 11.8 24.49 17.82 15.29
Standard Deviation 10.43 5.61 4.12 3.26 8.57 7.23
Log2 Mean 2.61 4.46 3.48 4.6 4.04 3.81
Log2 Standard Deviation 2.32 0.39 0.6 0.19 0.67 0.71
 
Vestibular ganglion
Replicate 1 36.51 10.97 15.13 28.96 20.94 22.56
Replicate 1 Call A A A A A A
Replicate 2 5.87 10.29 18.77 4.31 18.7 19.82
Replicate 2 Call A A A A A P
Replicate 3 6.53 18.82 20.47 14.52 23 24.56
Replicate 3 Call A A A A A A
Mean 16.3 13.36 18.12 15.93 20.88 22.31
Standard Deviation 17.5 4.74 2.73 12.39 2.15 2.38
Log2 Mean 3.48 3.68 4.17 3.61 4.38 4.47
Log2 Standard Deviation 1.48 0.48 0.22 1.39 0.15 0.16