GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description SRY (sex determining region Y)-box 2
Synonyms lcc; ysb; Sox-2
Chromosome 3
Genetic Map Distance 16.93 cM
RefSeq Accessions NM_011443; NP_035573
NCBI Entrez Gene 20674 at chr3:34548927-34551383 (mm9) / chr3:34650005-34652461 (mm10)
Ensembl Gene ENSMUSG00000074637
VEGA Gene OTTMUSG00000021249
MGI Gene MGI:98364
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
P48432 Transcription factor SOX-2 319 0
Q3UES8 Putative uncharacterized protein (Fragment) 230 0
Q3V2B6 Putative uncharacterized protein (Fragment) 268 0
Q60I23 SRY-box containing gene 2 319 0
Pfam Domains HMG_box; SOXp
Mouse alleles (19)
Allele Name Allele Type
Sox2lcc Radiation induced
Sox2tm1(cre/ERT2)Hoch Targeted (knock-in)
Sox2tm1.1Lan Targeted (Floxed/Frt)
Sox2tm1.1Vep Targeted (Reporter)
Sox2tm1Lpev Targeted (Reporter)
Sox2tm1Okud Targeted (Floxed/Frt)
Sox2tm1Rlb Targeted (Reporter)
Sox2tm1Skn Targeted (Reporter)
Sox2tm1Vep Targeted (knock-in)
Sox2tm2.1Lpev Targeted (knock-out)
Sox2tm2Hoch Targeted (knock-in)
Sox2tm2Lpev Targeted (Floxed/Frt)
Sox2tm2Skn Targeted (Reporter)
Sox2tm3(TK)Hoch Targeted (knock-in)
Sox2tm3Lpev Targeted (knock-out)
Sox2tm3Skn Targeted (knock-out)
Sox2tm4.1Skn Targeted (Floxed/Frt)
Sox2tm4Lpev Targeted (knock-out)
Sox2ysb Transgenic (random, gene disruption)
Human Homolog SOX2 (SRY (sex determining region Y)-box 2)
Human synonyms ANOP3; MCOPS3
Human cytoband 3q26.3-q27
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000008848 (SOX2_CHICK) encoding ENSGALP00000014363
ENSGALG00000008848 (SOX2_CHICK) encoding ENSGALP00000038846
Gene Ontology
Biological Process (66) lung alveolus development; positive regulation of epithelial cell differentiation; cell fate commitment; cell cycle arrest; stem cell differentiation; somatic stem cell maintenance; cerebral cortex development; diencephalon morphogenesis; regulation of cysteine-type endopeptidase activity involved in apoptotic process; forebrain neuron differentiation; positive regulation of MAPKKK cascade; neuron fate commitment; positive regulation of transcription; DNA-dependent; tongue development; negative regulation of epithelial cell proliferation; response to growth factor stimulus; anatomical structure formation involved in morphogenesis; embryonic organ development; stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuroblast proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuroblast proliferation; retina morphogenesis in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; sensory perception of sound; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription; DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription; DNA-dependent; transcription; DNA-dependent; cell fate specification; anatomical structure formation involved in morphogenesis; inner ear morphogenesis; endodermal cell fate specification; pigment biosynthetic process; regulation of transcription from RNA polymerase II promoter; detection of mechanical stimulus involved in sensory perception of sound; negative regulation of Wnt receptor signaling pathway; detection of mechanical stimulus involved in equilibrioception; negative regulation of osteoblast differentiation; olfactory placode formation; positive regulation of neuron differentiation; negative regulation of neuron differentiation; negative regulation of cell differentiation; positive regulation of Notch signaling pathway; male genitalia development; positive regulation of transcription from RNA polymerase II promoter; lens induction in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; response to retinoic acid; response to chemical stimulus; epithelial tube branching involved in lung morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of canonical Wnt receptor signaling pathway; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway; adenohypophysis development
Cellular Component (19) nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; nucleus; transcription factor complex; cytosol; soluble fraction; cytoplasm; cytoplasm; nucleus; nucleus
Molecular Function (33) transcription regulatory region DNA binding; transcription regulatory region DNA binding; transcription regulatory region DNA binding; miRNA binding; DNA binding; sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor binding; transcription regulatory region sequence-specific DNA binding; DNA binding; DNA binding; DNA binding; chromatin binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; protein binding; protein binding; protein binding; protein binding; protein binding; protein binding; protein binding; protein binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
19358
10145
7828
3830
2918
4902
Cochlea GFP+ cells
1696
4782
2401
965
160
NA
Utricle GFP- cells
419
3173
2439
1822
1014
2548
Cochlea GFP- cells
599
980
2208
944
875
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
1547
GFP+
5362
3.46
0.149
Utricle
5033
Cochlea
1561
0.31
1
Embryonic
5144
Postnatal
2490
0.48
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17396878 413.01 ± 32.90 161.83 ± 145.18 [91.25] 0.39 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
3937
4310
7080
3853
No bFGF
4409
5153
7219
5774
EGF
2122
2211
3227
2520
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
3853
No bFGF
5774
1.50
0.982
bFGF
3853
EGF
2520
0.65
5.51e-6
No bFGF
5774
EGF
2520
0.44
1.89e-21
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416967_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 3962.65 5048.5 104.87 2550.96 1346.06 1358.43
Replicate 1 Call P P P P P P
Replicate 2 3931.44 5266.7 104.1 1072.42 1093.9 419.35
Replicate 2 Call P P P P P P
Replicate 3 4215.26 5152.4 28.25 399.82 268.49 2580.53
Replicate 3 Call P P A P P P
Replicate 4 137.88 158.44 53.25 2805.61
Replicate 4 Call P P A P
Mean 4036.45 5155.87 93.78 1045.41 690.43 1790.98
Standard Deviation 155.64 109.14 46.43 1075.63 626.28 1113.75
Log2 Mean 11.98 12.33 6.34 9.33 8.57 10.48
Log2 Standard Deviation 0.06 0.03 1.03 1.74 2.16 1.27
 
Vestibular ganglion
Replicate 1 4153.29 4381.15 4951.28 5126.59 3732.33 3200.52
Replicate 1 Call P P P P P P
Replicate 2 4213.84 4593.39 5698.42 4495.54 4906.35 2895.11
Replicate 2 Call P P P P P P
Replicate 3 4343.71 4469.96 5294.65 5228.61 5214.85 2860.44
Replicate 3 Call P P P P P P
Mean 4236.95 4481.5 5314.78 4950.25 4617.84 2985.36
Standard Deviation 97.29 106.59 373.98 397.08 782.24 187.14
Log2 Mean 12.05 12.13 12.37 12.27 12.16 11.54
Log2 Standard Deviation 0.03 0.03 0.1 0.12 0.26 0.09