GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description sorbin and SH3 domain containing 2
Synonyms 2010203O03Rik; 9430041O17Rik
Chromosome 8
Genetic Map Distance 25.44 cM
RefSeq Accessions NM_001205219; NM_172752; NP_001192148; NP_766340; XR_105209; XR_107994
NCBI Entrez Gene 234214 at chr8:46593149-46913258 (mm9) / chr8:45507629-45827906 (mm10)
Ensembl Gene ENSMUSG00000031626
VEGA Gene OTTMUSG00000034076
MGI Gene MGI:1924574
Mouse Protein (14)
UniProt ID Description Length (AA) Predicted # TMs
Q3UTJ2 Sorbin and SH3 domain-containing protein 2 1180 0
B2RXQ9 Sorbs2 protein 652 0
B7ZWM6 Sorbs2 protein 1196 0
B9EKP8 Sorbs2 protein 1214 0
D3YTN2 Uncharacterized protein 75 0
D3YUT0 Uncharacterized protein 92 0
D3YY43 Uncharacterized protein 51 0
D3Z080 Uncharacterized protein 707 0
D3Z0E9 Uncharacterized protein 42 0
D3Z0N2 Uncharacterized protein 57 0
D3Z203 Uncharacterized protein 212 0
D3Z2C7 Uncharacterized protein 47 0
D3Z4W6 Uncharacterized protein 58 0
Q3UX22 Putative uncharacterized protein 121 0
Pfam Domains Sorb; Pfam-B_16901; SH3_2; SH3_1; SH3_1
Mouse alleles (1)
Allele Name Allele Type
Sorbs2tm1(KOMP)Mbp KOMP-CSD-Project
Human Homolog SORBS2 (sorbin and SH3 domain containing 2)
Human synonyms ARGBP2; PRO0618
Human cytoband 4q35.1
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000013427 (SORBS2) encoding ENSGALP00000021860
Gene Ontology
Cellular Component (7) cytoplasm; cytoskeleton; cell junction; intracellular; postsynaptic density; dendrite; neuronal cell body
Molecular Function (2) molecular_function; zinc ion binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
14370
35195
14428
17083
20076
17525
Cochlea GFP+ cells
3926
3498
8913
7353
9646
NA
Utricle GFP- cells
3085
10177
8103
3146
5933
8748
Cochlea GFP- cells
1536
1757
1338
769
1280
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
4170
GFP+
13819
3.31
0.148
Utricle
13156
Cochlea
4002
0.30
0.779
Embryonic
9193
Postnatal
8882
0.97
0.796
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17500876 169.34 ± 19.81 331.13 ± 37.18 [266.25] 1.96 0.2
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
86
92
69
62
No bFGF
140
145
117
129
EGF
431
449
383
421
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
62
No bFGF
129
2.07
0.936
bFGF
62
EGF
421
6.76
9.71e-24
No bFGF
129
EGF
421
3.26
7.4e-15
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000021860
Symbol SORBS2
Description Sorbin and SH3 domain containing 2
log10 riBAQ in stereocilia (mean ± sd) -4.96 ± 0.30
log10 riBAQ in utricle (mean ± sd) -4.22 ± 0.19
Molecules per stereocilium (mean ± error with slope error) 16.08 ± 1.08
Corrected Molecules per stereocilium (mean ± sd) -1.52 ± 23.05
Stereocilium / Utricle ratio (mean ± sd) 0.18 ± 0.02
Enriched in the stereocilia (FDR < 0.05) FALSE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1431192_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 16.53 16.49 13.08 6.36 3.54 20.23
Replicate 1 Call A A A A A A
Replicate 2 20.36 9.62 26.67 1.77 11 7.84
Replicate 2 Call A A A A A A
Replicate 3 28.81 30.37 25.23 8.45 1 4.43
Replicate 3 Call A A A A A A
Replicate 4 21.44 10.43 6.12 9.59
Replicate 4 Call P A A A
Mean 21.9 18.83 21.61 6.75 5.42 10.52
Standard Deviation 6.28 10.57 6.1 3.71 4.27 6.82
Log2 Mean 4.41 4.08 4.38 2.49 1.97 3.18
Log2 Standard Deviation 0.4 0.83 0.47 1.15 1.48 0.91
 
Vestibular ganglion
Replicate 1 43.73 10.2 10.18 17.63 15.24 3.93
Replicate 1 Call A A A A A A
Replicate 2 36.06 22.76 11.35 22.43 14.97 9.33
Replicate 2 Call A A A A A A
Replicate 3 30.64 17.91 9.54 1.95 13.63 10.02
Replicate 3 Call A A A A A A
Mean 36.81 16.96 10.36 14 14.61 7.76
Standard Deviation 6.58 6.33 0.92 10.71 0.86 3.33
Log2 Mean 5.19 4.01 3.37 3.2 3.87 2.84
Log2 Standard Deviation 0.26 0.59 0.13 1.94 0.09 0.75
Probe set ID: 1441624_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1461.89 2136.98 2089.07 1376.82 344.55 664.73
Replicate 1 Call P P P P P P
Replicate 2 1510.93 2417.75 3335.48 601.42 821.15 411.85
Replicate 2 Call P P P P P P
Replicate 3 1630.11 2486.17 1339.49 823.19 590.32 607.57
Replicate 3 Call P P P P P P
Replicate 4 3131.6 270.09 876.03 652.92
Replicate 4 Call P P P P
Mean 1534.31 2346.97 2473.91 767.88 658.01 584.27
Standard Deviation 86.51 185.04 932.71 465.25 242.89 117.56
Log2 Mean 10.58 11.19 11.18 9.36 9.27 9.17
Log2 Standard Deviation 0.08 0.12 0.61 0.98 0.62 0.32
 
Vestibular ganglion
Replicate 1 2270.95 1830.2 475.43 426.76 181.55 409.9
Replicate 1 Call P P P P A P
Replicate 2 2381.17 2056.69 1042.9 179.12 553.17 222.85
Replicate 2 Call P P P P P P
Replicate 3 2256.12 1861.22 737.66 617.59 480.41 204.09
Replicate 3 Call P P P P P P
Mean 2302.75 1916.04 752 407.82 405.04 278.95
Standard Deviation 68.32 122.79 284.01 219.85 196.94 113.8
Log2 Mean 11.17 10.9 9.48 8.5 8.51 8.05
Log2 Standard Deviation 0.04 0.09 0.57 0.92 0.88 0.55
Probe set ID: 1446744_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 8.82 7.85 11.1 13.6 33.35 40.12
Replicate 1 Call A A A A A A
Replicate 2 3.37 4.07 15.8 3.1 24 37.13
Replicate 2 Call A A A A A A
Replicate 3 3.06 32.98 20.14 8.5 43.62 63.06
Replicate 3 Call A A A A A A
Replicate 4 28.6 4.68 36.32 55.6
Replicate 4 Call A A A A
Mean 5.08 14.97 18.91 7.47 34.32 48.98
Standard Deviation 3.24 15.71 7.44 4.67 8.12 12.4
Log2 Mean 2.17 3.35 4.16 2.68 5.07 5.58
Log2 Standard Deviation 0.84 1.54 0.58 0.94 0.36 0.37
 
Vestibular ganglion
Replicate 1 1 25.16 1.44 2.36 21.34 13.42
Replicate 1 Call A A A A A A
Replicate 2 7.01 14.11 11.95 78.21 3.36 7.9
Replicate 2 Call A A A A A A
Replicate 3 3.88 16.3 1 40.95 22.4 7.93
Replicate 3 Call A A A A A A
Mean 3.96 18.52 4.8 40.51 15.7 9.75
Standard Deviation 3.01 5.85 6.2 37.93 10.7 3.18
Log2 Mean 1.59 4.17 1.37 4.29 3.55 3.24
Log2 Standard Deviation 1.44 0.43 1.93 2.69 1.56 0.44