GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description snail family zinc finger 2
Synonyms Snail2; Slug; Slugh
Chromosome 16
Genetic Map Distance 10.07 cM
RefSeq Accessions NM_011415; NP_035545
NCBI Entrez Gene 20583 at chr16:14705952-14709478 (mm9) / chr16:14705859-14709385 (mm10)
Ensembl Gene ENSMUSG00000022676
VEGA Gene
MGI Gene MGI:1096393
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
P97469 Zinc finger protein SNAI2 269 0
Q3UZ96 Putative uncharacterized protein 269 0
Pfam Domains Pfam-B_4487; Pfam-B_12465; CTNNB1_binding; zf-C2H2; Elf1; zf-C2H2; zf-C2H2; Elf1; zf-C2H2; zf-C2H2
Mouse alleles (5)
Allele Name Allele Type
Snai2tm1e(EUCOMM)Hmgu EUCOMM-projects
Snai2tm1(KOMP)Vlcg KOMP-Regeneron-Project
Snai2tm1Grid Targeted (Reporter)
Snai2tm1Look Targeted (knock-out)
Snai2tm2Grid Targeted (knock-out)
Human Homolog SNAI2 (snail homolog 2 (Drosophila))
Human synonyms SLUG; SLUGH1; SNAIL2; WS2D
Human cytoband 8q11
Known deafness gene WS2D
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000015241 (SNAI2) encoding ENSGALP00000024548
ENSGALG00000022403
Gene Ontology
Biological Process (49) response to radiation; palate development; response to radiation; cartilage morphogenesis; regulation of survival gene product expression; negative regulation of keratinocyte proliferation; negative regulation of apoptotic process; negative regulation of vitamin D biosynthetic process; negative regulation of apoptotic process; neural crest cell development; cell migration; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of chemokine production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of catenin import into nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of DNA damage response; signal transduction by p53 class mediator; negative regulation of cell adhesion involved in substrate-bound cell migration; canonical Wnt receptor signaling pathway; positive regulation of fat cell differentiation; negative regulation of vitamin D receptor signaling pathway; white fat cell differentiation; cellular response to epidermal growth factor stimulus; positive regulation of fat cell differentiation; negative regulation of canonical Wnt receptor signaling pathway; epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of histone acetylation; negative regulation of stem cell proliferation; epithelium development; regulation of tight junction assembly; desmosome disassembly; desmosome disassembly; pigmentation; pigmentation; cellular response to ionizing radiation; transcription; DNA-dependent; multicellular organismal development; regulation of transcription; DNA-dependent; positive regulation of survival gene product expression; positive regulation of cell migration; regulation of osteoblast differentiation; embryo development; epithelial to mesenchymal transition; epithelial to mesenchymal transition; epithelial to mesenchymal transition; sensory perception of sound; sensory perception of sound; palate development
Cellular Component (6) nuclear chromatin; intracellular; nucleus; nucleus; nucleus; cytoplasm
Molecular Function (10) sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; sequence-specific DNA binding; chromatin binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; metal ion binding; DNA binding; zinc ion binding; nucleic acid binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
73
59
15
9
23
39
Cochlea GFP+ cells
185
108
23
18
12
NA
Utricle GFP- cells
460
494
166
76
60
503
Cochlea GFP- cells
421
485
783
261
263
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
361
GFP+
51
0.14
0.0345
Utricle
165
Cochlea
256
1.55
1
Embryonic
285
Postnatal
161
0.56
0.368
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17323192 11.76 ± 0.00 11.61 ± 0.95 [12.29] 0.99 0.899
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
45
45
37
169
No bFGF
67
64
71
57
EGF
39
42
71
51
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
169
No bFGF
57
0.34
0.0817
bFGF
169
EGF
51
0.30
1.7e-14
No bFGF
57
EGF
51
0.89
0.731
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1418673_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 114.15 85.81 35.39 103.03 198.69 415.69
Replicate 1 Call A A A A P P
Replicate 2 120.51 74.73 73.79 387.4 382.29 604.76
Replicate 2 Call A A A P P P
Replicate 3 121.52 81.71 60.23 39.11 338.73 302.99
Replicate 3 Call A A A A P P
Replicate 4 131.81 52.1 467.36 400.75
Replicate 4 Call A A P P
Mean 118.73 80.75 75.31 145.41 346.77 431.05
Standard Deviation 4 5.6 40.89 163.67 112.24 126.13
Log2 Mean 6.89 6.33 6.08 6.57 8.37 8.71
Log2 Standard Deviation 0.05 0.1 0.78 1.47 0.53 0.41
 
Vestibular ganglion
Replicate 1 98.99 71.16 442.22 156.26 125.19 136.93
Replicate 1 Call A A A A A A
Replicate 2 101.26 69.64 678.17 236.53 314.61 122.78
Replicate 2 Call A A P A P A
Replicate 3 96.96 86.05 320.91 96.64 284.48 117.31
Replicate 3 Call A P A A A P
Mean 99.07 75.62 480.43 163.14 241.43 125.67
Standard Deviation 2.15 9.07 181.67 70.2 101.78 10.12
Log2 Mean 6.63 6.23 8.84 7.26 7.81 6.97
Log2 Standard Deviation 0.03 0.17 0.54 0.65 0.73 0.11
Probe set ID: 1447643_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 646.31 298.98 121.92 417.95 1810.12 2760.71
Replicate 1 Call P P P P P P
Replicate 2 627.03 266.75 368.89 2288.56 2271.07 3282.54
Replicate 2 Call P P P P P P
Replicate 3 694.09 402.41 196.48 55.4 2559.53 1910.1
Replicate 3 Call P P P P P P
Replicate 4 937.39 152.14 3055.88 3182.59
Replicate 4 Call P P P P
Mean 655.81 322.71 406.17 728.51 2424.15 2783.99
Standard Deviation 34.52 70.88 368.94 1051.27 522.14 624.94
Log2 Mean 9.36 8.31 8.24 8.23 11.22 11.41
Log2 Standard Deviation 0.08 0.31 1.27 2.29 0.32 0.36
 
Vestibular ganglion
Replicate 1 700.7 353.65 2856.05 1100.6 964.89 511.86
Replicate 1 Call P P P P P P
Replicate 2 677.34 438.57 3384.1 1630.11 1831.18 440.92
Replicate 2 Call P P P P P P
Replicate 3 650.17 426.68 1846.99 507.59 1902.74 466.47
Replicate 3 Call P P P P P P
Mean 676.07 406.3 2695.71 1079.43 1566.27 473.08
Standard Deviation 25.29 45.98 781 561.56 522.04 35.93
Log2 Mean 9.4 8.66 11.35 9.92 10.55 8.88
Log2 Standard Deviation 0.05 0.17 0.45 0.86 0.55 0.11