SHIELD | Shared Harvard Inner-Ear Laboratory Database

GENE VIEW

Slc4a11

MOUSE GENE INFORMATION [PubMed]

Description

solute carrier family 4, sodium bicarbonate transporter-like, member 11

Synonyms

Chromosome

Genetic Map Distance

63.24 cM

RefSeq Accessions

NM_001081162; NP_001074631

NCBI Entrez Gene

269356 at chr2:130509844-130523255 (mm9) / chr2:130684107-130697519 (mm10)

Ensembl Gene

ENSMUSG00000074796

VEGA Gene

OTTMUSG00000015523

MGI Gene

MGI:2138987

Mouse Protein (2)

UniProt ID	Description	Length (AA)	Predicted # TMs
A2AJN7	Sodium bicarbonate transporter-like protein 11	862	11
A2AJN8	Solute carrier family 4, sodium bicarbonate transporter-like, member 11 (Fragment)	164	0

Pfam Domains

PTS_EIIA_2; HCO3_cotransp; Pfam-B_1083

Mouse alleles (4)

Allele Name	Allele Type
Slc4a11^{tm1a(EUCOMM)Hmgu}	EUCOMM-projects
Slc4a11^{tm1(KOMP)Vlcg}	KOMP-Regeneron-Project
Slc4a11^{Gt(OST443317)Lex}	Gene trapped
Slc4a11^tm1Boet	Targeted (Reporter)

Human Homolog

SLC4A11 (solute carrier family 4, sodium borate transporter, member 11)

Human synonyms

BTR1; CHED2; dJ794I6.2; NABC1

Human cytoband

20p12

Known deafness gene

Within mapped deafness loci

Associated Human Disease in OMIM

Corneal Dystrophy and Perceptive Deafness [CDPD|Cdpd1|Corneal Dystrophy and Sensorineural Deafness|Harboyan Syndrome]

Corneal Endothelial Dystrophy 2, Autosomal Recessive; CHED2 [Congenital Hereditary Endothelial Dystrophy of Cornea|Corneal Dystrophy, Congenital Hereditary Endothelial|Maumenee Corneal Dystrophy]

Corneal Dystrophy, Fuchs Endothelial, 4; FECD4 [Corneal Dystrophy, Fuchs Endothelial, Late-Onset]

Chicken homolog (1)

ENSGALG00000016017 (SLC4A11) encoding ENSGALP00000025756

Gene Ontology

Biological Process (19)	borate transport; ion homeostasis; fluid transport; carbohydrate transmembrane transport; ion transmembrane transport; ion transmembrane transport; transmembrane transport; phosphoenolpyruvate-dependent sugar phosphotransferase system; anion transport; transport; transport; ion transport; sodium ion transport; bicarbonate transport; proton transport; proton transport; cellular cation homeostasis; borate transmembrane transport; sodium ion transmembrane transport
Cellular Component (5)	membrane; membrane; integral to membrane; integral to membrane; plasma membrane
Molecular Function (10)	borate transmembrane transporter activity; protein dimerization activity; sugar:hydrogen symporter activity; transporter activity; sodium channel activity; anion:anion antiporter activity; symporter activity; inorganic anion exchanger activity; bicarbonate transmembrane transporter activity; hydrogen ion channel activity

FACS-Sorted Hair Cells

Data | Chart

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
GFP-	2	GFP+	1	0.65	0.71
Utricle	2	Cochlea	1	0.47	1
Embryonic	0	Postnatal	2	3.99	0.922

Adult Cochlear Inner and Outer Hair Cells

Probeset ID	IHC (mean ± sd)	OHC (mean ± sd) [OHC replicate]	Fold Change (OHC/IHC)	False Discovery Rate (FDR)
17391709	14.28 ± 0.21	14.55 ± 29.34 [82.31]	1.02	0.554

Otic Progenitor Cells

Data

Growth Factor	Replicate 1	Replicate 2	Replicate 3	Mean
bFGF	105	111	133	89
No bFGF	91	91	136	110
EGF	47	48	47	47

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
bFGF	89	No bFGF	110	1.23	1
bFGF	89	EGF	47	0.54	0.000846
No bFGF	110	EGF	47	0.43	1.53e-6

Chicken Stereocilium Proteomics

The chicken protein was not reproducibly detected in the chicken stereocilia.

The chicken protein was not reproducibly detected in the chicken stereocilia.

Auditory and Vestibular Ganglion Neurons

Probe set ID: 1434867_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	1376.81	1412.26	1884.37	2139.99	1980.69	1588.9
Replicate 1 Call	M	A	A	P	P	A
Replicate 2	1365.44	1568.91	2136.65	2373.94	2457.98	1573.32
Replicate 2 Call	P	A	A	P	P	A
Replicate 3	1243.88	1322.93	2083.12	2388.27	1768.95	1881.12
Replicate 3 Call	P	A	A	P	P	A
Replicate 4			2153.6	2383.28	1863.97	2109.16
Replicate 4 Call			P	P	A	P
Mean	1328.71	1434.7	2064.44	2321.37	2017.9	1788.13
Standard Deviation	73.68	124.52	123.74	121.07	305.9	256.61
Log2 Mean	10.37	10.48	11.01	11.18	10.97	10.79
Log2 Standard Deviation	0.08	0.12	0.09	0.08	0.21	0.2

Vestibular ganglion
Replicate 1	1309.64	1745.84	1353.1	1176.38	1256.97	1687.43
Replicate 1 Call	P	A	P	P	A	A
Replicate 2	1320.96	1682.62	1374.46	1506.89	1275.04	1555.52
Replicate 2 Call	A	P	P	M	A	A
Replicate 3	1410.33	1637.86	1115.44	1445.58	1306.4	1479.29
Replicate 3 Call	P	P	P	A	A	A
Mean	1346.98	1688.77	1281	1376.28	1279.47	1574.08
Standard Deviation	55.16	54.25	143.78	175.81	25.01	105.3
Log2 Mean	10.39	10.72	10.32	10.42	10.32	10.62
Log2 Standard Deviation	0.06	0.05	0.17	0.19	0.03	0.1

Probe set ID: 1457989_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	174.9	357.49	230.07	202.06	127.22	116.63
Replicate 1 Call	A	P	A	A	A	A
Replicate 2	206.07	325.42	170.22	131.52	152.48	72.07
Replicate 2 Call	A	A	A	A	P	A
Replicate 3	198.06	273.36	225.63	182.94	112.31	150.29
Replicate 3 Call	A	A	P	A	A	A
Replicate 4			141.46	181.88	105.82	141.01
Replicate 4 Call			A	A	A	A
Mean	193.01	318.76	191.85	174.6	124.46	120
Standard Deviation	16.19	42.46	43.24	30.18	20.72	34.96
Log2 Mean	7.59	8.31	7.55	7.43	6.95	6.85
Log2 Standard Deviation	0.12	0.2	0.34	0.27	0.23	0.48

Vestibular ganglion
Replicate 1	230.42	207.86	93.9	138.9	132.09	194.96
Replicate 1 Call	A	P	A	A	A	A
Replicate 2	190.3	243.21	146.9	158.83	173.77	218.61
Replicate 2 Call	A	P	A	A	A	A
Replicate 3	188.26	238.95	184.24	164.14	159.35	167.6
Replicate 3 Call	A	A	A	A	A	A
Mean	202.99	230.01	141.68	153.96	155.07	193.72
Standard Deviation	23.77	19.3	45.4	13.31	21.17	25.53
Log2 Mean	7.66	7.84	7.09	7.26	7.27	7.59
Log2 Standard Deviation	0.16	0.12	0.49	0.13	0.2	0.19

Utricle GFP+ cells

Cochlea GFP+ cells

Utricle GFP- cells

Cochlea GFP- cells