GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description solute carrier family 25, member 37
Synonyms mitoferrin; Mscp; Mfrn; 1700020E22Rik; Frascati; Mfrn1; C330015G08Rik; 4930513O14Rik; 4930526G11Rik
Chromosome 14
Genetic Map Distance 36.03 cM
RefSeq Accessions NM_026331; NM_030054; NP_080607
NCBI Entrez Gene 67712 at chr14:69859908-69903160 (mm9) / chr14:69241848-69285190 (mm10)
Ensembl Gene ENSMUSG00000034248
VEGA Gene
MGI Gene MGI:1914962
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q920G8 Mitoferrin-1 338 0
Q9CQG7 Slc25a37 protein 187 0
Pfam Domains Mito_carr; Mito_carr; Mito_carr
Mouse alleles (3)
Allele Name Allele Type
Slc25a37Gt(XB454)Byg Gene trapped
Slc25a37tm1.1Kapl Targeted (Floxed/Frt)
Slc25a37tm1.2Kapl Targeted (knock-out)
Human Homolog SLC25A37 (solute carrier family 25, member 37)
Human synonyms MFRN; MFRN1; MSC; MSCP; PRO1278; PRO1584; PRO2217
Human cytoband 8p21.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000000378 (SLC25A37) encoding ENSGALP00000000517
Gene Ontology
Biological Process (4) ion transport; iron ion homeostasis; transport; mitochondrial iron ion transport
Cellular Component (5) membrane; mitochondrial inner membrane; mitochondrion; integral to membrane; intracellular
Molecular Function (1) iron ion transmembrane transporter activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
420
266
405
1106
1100
620
Cochlea GFP+ cells
187
231
452
1146
1805
NA
Utricle GFP- cells
3621
2824
371
1664
912
487
Cochlea GFP- cells
3964
1410
242
403
421
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
1484
GFP+
704
0.47
0.339
Utricle
1150
Cochlea
1026
0.89
0.89
Embryonic
1615
Postnatal
795
0.49
0.0835
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17308132 132.48 ± 11.33 132.58 ± 30.61 [93.77] 1.00 0.953
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1599
1699
1769
1664
No bFGF
1480
1354
1490
1188
EGF
587
623
636
615
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1664
No bFGF
1188
0.71
0.776
bFGF
1664
EGF
615
0.37
7.26e-25
No bFGF
1188
EGF
615
0.52
2.16e-10
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1417750_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1172.04 1625.71 929.01 1199.97 1106.65 2187.08
Replicate 1 Call P P P P P P
Replicate 2 1184.41 1617.88 727.91 893.32 1633.88 3181.41
Replicate 2 Call P P P P P P
Replicate 3 1400.51 1420.55 651.7 806.53 1108.54 2661.52
Replicate 3 Call P P P P P P
Replicate 4 1054.23 903.01 828 2874.47
Replicate 4 Call P P P P
Mean 1252.32 1554.71 840.71 950.71 1169.27 2726.12
Standard Deviation 128.49 116.25 184.24 171.74 336.62 417.94
Log2 Mean 10.29 10.6 9.69 9.88 10.15 11.4
Log2 Standard Deviation 0.14 0.11 0.32 0.25 0.4 0.23
 
Vestibular ganglion
Replicate 1 1170.4 1207.61 4803.81 3709.72 2289.52 2923.76
Replicate 1 Call P P P P P P
Replicate 2 1237.19 1298.8 4686.08 2821.64 2079.11 2057.62
Replicate 2 Call P P P P P P
Replicate 3 1016.23 1467.53 4232.01 2318.14 2536.39 1973.24
Replicate 3 Call P P P P P P
Mean 1141.27 1324.65 4573.97 2949.83 2301.67 2318.21
Standard Deviation 113.32 131.87 301.94 704.59 228.88 526.12
Log2 Mean 10.15 10.37 12.16 11.5 11.16 11.16
Log2 Standard Deviation 0.15 0.14 0.1 0.34 0.14 0.31