GENE VIEW

Six2

MOUSE GENE INFORMATION [PubMed]

Description

sine oculis-related homeobox 2

Synonyms

Chromosome

17

Genetic Map Distance

55.72 cM

RefSeq Accessions

NM_011380; NP_035510

NCBI Entrez Gene

20472 at chr17:86083608-86087594 (mm9) / chr17:85684267-85688254 (mm10)

Ensembl Gene

ENSMUSG00000024134

VEGA Gene

MGI Gene

Mouse Protein (1)

UniProt ID	Description	Length (AA)	Predicted # TMs
Q62232	Homeobox protein SIX2	296	0

Pfam Domains

Homeobox; Pfam-B_12718

Mouse alleles (4)

Allele Name	Allele Type
Six2^{tm1(tTA,tetO-EGFP/cre)Amc}	Targeted (knock-in)
Six2^tm1Gco	Targeted (knock-out)
Six2^{tm2(cre/ERT2)Amc}	Targeted (knock-in)
Six2^{tm3(EGFP/cre/ERT2)Amc}	Targeted (knock-in)

Human Homolog

SIX2 (SIX homeobox 2)

Human synonyms

Human cytoband

2p21

Known deafness gene

No

Within mapped deafness loci

No

Associated Human Disease in OMIM

None

Chicken homolog (0)

Biological Process (13)	middle ear morphogenesis; multicellular organismal development; regulation of transcription; DNA-dependent; mesodermal cell fate specification; kidney development; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus; metanephros development; negative regulation of cell differentiation; embryonic cranial skeleton morphogenesis; chondrocyte differentiation; cell proliferation; embryonic skeletal system morphogenesis
Cellular Component (2)	nucleus; nucleus
Molecular Function (6)	protein binding; sequence-specific DNA binding transcription factor activity; DNA binding; protein complex binding; sequence-specific DNA binding; sequence-specific DNA binding

FACS-Sorted Hair Cells

Data | Chart

	E16a	E16b	P0	P4	P7	P16
Utricle GFP+ cells	34	20	81	79	57	281
Cochlea GFP+ cells	56	98	16	249	455	NA
Utricle GFP- cells	104	48	41	19	31	47
Cochlea GFP- cells	54	12	4	2	5	NA

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
GFP-	33	GFP+	130	3.85	0.222
Utricle	70	Cochlea	95	1.35	1
Embryonic	53	Postnatal	98	1.82	1

Adult Cochlear Inner and Outer Hair Cells

Probeset ID	IHC (mean ± sd)	OHC (mean ± sd) [OHC replicate]	Fold Change (OHC/IHC)	False Discovery Rate (FDR)
17347839	49.70 ± 12.72	149.65 ± 29.61 [182.58]	3.01	0.323

Otic Progenitor Cells

Data

Growth Factor	Replicate 1	Replicate 2	Replicate 3	Mean
bFGF	17	16	24	190
No bFGF	17	15	25	16
EGF	33	31	40	35

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
bFGF	190	No bFGF	16	0.09	1.95e-7
bFGF	190	EGF	35	0.18	4.49e-27
No bFGF	16	EGF	35	2.07	0.00963

Chicken Stereocilium Proteomics

No chicken homolog has been identified for Six2.

Auditory and Vestibular Ganglion Neurons

Probe set ID: 1427436_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	1888.53	1401.68	2087.56	1762.69	1462.32	1158.2
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	1924.83	1710.28	2397.5	1671.14	2205.86	1313.64
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	2028.19	1764.72	2313.41	1994.09	1462.17	1636.44
Replicate 3 Call	P	P	P	P	P	P
Replicate 4			2005.57	1979.65	1278.62	1851.91
Replicate 4 Call			P	P	P	P
Mean	1947.18	1625.56	2201.01	1851.89	1602.24	1490.05
Standard Deviation	72.46	195.79	184.67	160.39	411.62	312.85
Log2 Mean	10.93	10.66	11.1	10.85	10.61	10.52
Log2 Standard Deviation	0.05	0.18	0.12	0.13	0.34	0.31

Vestibular ganglion
Replicate 1	3054.43	2757.8	1387.04	1338.53	887.38	1133.73
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	2957.39	2501.6	1670.21	1558.88	1172.38	1256.71
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	3074.29	2382.07	1371.19	1435.02	1007.12	1142.44
Replicate 3 Call	P	P	P	P	P	P
Mean	3028.7	2547.16	1476.15	1444.14	1022.29	1177.63
Standard Deviation	62.55	191.96	168.25	110.46	143.1	68.63
Log2 Mean	11.56	11.31	10.52	10.49	9.99	10.2
Log2 Standard Deviation	0.03	0.11	0.16	0.11	0.2	0.08