GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description sine oculis-related homeobox 1
Synonyms
Chromosome 12
Genetic Map Distance 30.34 cM
RefSeq Accessions NM_009189; NP_033215
NCBI Entrez Gene 20471 at chr12:74142814-74147699 (mm9) / chr12:73041827-73046712 (mm10)
Ensembl Gene ENSMUSG00000051367
VEGA Gene
MGI Gene MGI:102780
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q62231 Homeobox protein SIX1 284 0
Q3V2C3 Putative uncharacterized protein 284 0
Q8BSP4 Putative uncharacterized protein 284 0
Pfam Domains Homeobox; Pfam-B_12718
Mouse alleles (7)
Allele Name Allele Type
Six1Cwe Chemically induced (ENU)
Six1tm1(cre)Xli Targeted (knock-in)
Six1tm1(cre,ALPP)Xli Targeted (knock-in)
Six1tm1Kwk Targeted (knock-out)
Six1tm1Mair Targeted (Reporter)
Six1tm1Rsd Targeted (Reporter)
Six1tm2Kwk Targeted (knock-out)
Human Homolog SIX1 (SIX homeobox 1)
Human synonyms BOS3; DFNA23; TIP39
Human cytoband 14q23.1
Known deafness gene DFNA23/BOS3
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (0)
Gene Ontology
Biological Process (49) positive regulation of transcription; DNA-dependent; metanephric mesenchyme development; multicellular organismal development; positive regulation of ureteric bud formation; transcription; DNA-dependent; thyroid gland development; positive regulation of branching involved in ureteric bud morphogenesis; branching involved in ureteric bud morphogenesis; cochlea morphogenesis; positive regulation of transcription from RNA polymerase II promoter; aorta morphogenesis; positive regulation of transcription from RNA polymerase II promoter; epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; thymus development; anatomical structure development; outflow tract morphogenesis; pharyngeal system development; organ induction; pattern specification process; middle ear morphogenesis; positive regulation of secondary heart field cardioblast proliferation; sensory perception of sound; ureter smooth muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mesenchymal cell proliferation involved in ureter development; facial nerve morphogenesis; skeletal system morphogenesis; negative regulation of branching involved in ureteric bud morphogenesis; pattern specification process; renal system development; regulation of transcription; DNA-dependent; skeletal muscle tissue development; ureteric bud development; ureteric bud development; inner ear morphogenesis; regulation of neuron differentiation; myoblast migration; embryonic skeletal system morphogenesis; protein localization to nucleus; generation of neurons; thymus development; mesonephric tubule formation; inner ear development; regulation of branch elongation involved in ureteric bud branching; negative regulation of neuron apoptosis; otic vesicle development; embryonic cranial skeleton morphogenesis; kidney development
Cellular Component (6) nucleolus; nucleus; transcription factor complex; transcription factor complex; nucleus; nucleus
Molecular Function (10) DNA binding; sequence-specific DNA binding transcription factor activity; protein binding; protein binding; protein binding; sequence-specific DNA binding; chromatin binding; sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
15784
18300
17219
14401
12664
18309
Cochlea GFP+ cells
19101
12325
16374
14661
14881
NA
Utricle GFP- cells
3732
6307
2902
1724
1580
3493
Cochlea GFP- cells
5296
5431
4427
3135
5277
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
3937
GFP+
15820
4.02
0.0812
Utricle
9701
Cochlea
10091
1.04
1
Embryonic
10785
Postnatal
9360
0.87
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17281880 361.48 ± 22.97 325.30 ± 25.62 [355.58] 0.90 0.547
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
4
4
1
636
No bFGF
3
5
7
6
EGF
3
2
4
3
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
636
No bFGF
6
0.01
5.17e-31
bFGF
636
EGF
3
0.01
8.81e-176
No bFGF
6
EGF
3
0.54
0.24
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Six1.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1427277_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 3388.93 3090.78 1947.95 1484.15 828.68 795.56
Replicate 1 Call P P P P P P
Replicate 2 3555.06 3533.77 2009.86 1100.69 1143.87 475.26
Replicate 2 Call P P P P P P
Replicate 3 3679.69 3333.73 1915.75 1884.16 744.39 976.85
Replicate 3 Call P P P P P P
Replicate 4 1697.55 2027.64 700.73 1058.07
Replicate 4 Call P P P P
Mean 3541.23 3319.43 1892.78 1624.16 854.42 826.44
Standard Deviation 145.87 221.84 135.88 417.94 200.14 258.56
Log2 Mean 11.79 11.69 10.88 10.63 9.71 9.63
Log2 Standard Deviation 0.06 0.1 0.11 0.4 0.31 0.52
 
Vestibular ganglion
Replicate 1 2649.48 1989.58 744.71 830.27 677.26 920.16
Replicate 1 Call P P P P P P
Replicate 2 2574.19 2170.31 992.85 880.03 929.62 1018.55
Replicate 2 Call P P P P P P
Replicate 3 2423.64 2024.05 686.62 666.58 864.11 909.08
Replicate 3 Call P P P P P P
Mean 2549.1 2061.31 808.06 792.29 823.66 949.26
Standard Deviation 114.99 95.95 162.65 111.68 130.95 60.26
Log2 Mean 11.31 11.01 9.64 9.62 9.67 9.89
Log2 Standard Deviation 0.07 0.07 0.28 0.21 0.24 0.09