MOUSE GENE INFORMATION [
PubMed]
| Description |
SH3/ankyrin domain gene 1 |
| Synonyms |
|
| Chromosome |
7 |
| Genetic Map Distance |
28.83 cM |
| RefSeq Accessions |
NM_001034115; NP_001029287 |
| NCBI Entrez Gene |
243961 at
chr7:51565634-51613723 (mm9)
/
chr7:44307933-44358353 (mm10)
|
| Ensembl Gene |
ENSMUSG00000038738
|
| VEGA Gene |
OTTMUSG00000016443
|
| MGI Gene |
MGI:3613677
|
| Mouse Protein (4) |
| UniProt ID |
Description |
Length (AA) |
Predicted # TMs |
|
D3YYJ0
|
Uncharacterized protein
|
722 |
0 |
|
D3YZU1
|
Uncharacterized protein
|
2167 |
0 |
|
D3YZU4
|
Uncharacterized protein
|
2159 |
0 |
|
D3YZU5
|
Uncharacterized protein
|
2158 |
0 |
|
| Pfam Domains |
Ank; Ank; Defensin_2; Ank; Ank; Ank; SH3_2; PDZ |
| Mouse alleles (1) |
|
| Human Homolog |
SHANK1
(SH3 and multiple ankyrin repeat domains 1)
|
| Human synonyms |
SPANK-1; SSTRIP; synamon
|
| Human cytoband |
19q13.3 |
| Known deafness gene |
No
|
| Within mapped deafness loci |
No
|
| Associated Human Disease in OMIM |
None
|
| Chicken homolog (0) |
|
|
Gene Ontology
|
| Biological Process
(13) |
associative learning; dendritic spine morphogenesis; long-term memory; neuromuscular process controlling balance; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; protein localization to synapse; negative regulation of actin filament bundle assembly; cell differentiation; nervous system development; protein complex assembly; positive regulation of excitatory postsynaptic membrane potential; synapse maturation; positive regulation of dendritic spine development |
| Cellular Component
(13) |
excitatory synapse; membrane fraction; membrane fraction; cytoplasm; membrane; plasma membrane; cell junction; postsynaptic density; N-methyl-D-aspartate selective glutamate receptor complex; dendritic spine; synapse; postsynaptic membrane; postsynaptic membrane |
| Molecular Function
(12) |
GKAP/Homer scaffold activity; GKAP/Homer scaffold activity; ionotropic glutamate receptor binding; ionotropic glutamate receptor binding; protein C-terminus binding; SH3 domain binding; receptor signaling complex scaffold activity; somatostatin receptor binding; protein complex binding; identical protein binding; ankyrin repeat binding; scaffold protein binding |
|
FACS-Sorted Hair Cells
Shank1 is not detected by RNA-Seq.
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID |
IHC (mean ± sd) |
OHC (mean ± sd) [OHC replicate] |
Fold Change (OHC/IHC) |
False Discovery Rate (FDR) |
| 17477428 |
10.35
±
0.17 |
11.27
±
1.44
[14.34]
|
1.09 |
0.501 |
Otic Progenitor Cells
Shank1 is not detected by RNA-Seq.
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Shank1.
Auditory and Vestibular Ganglion Neurons
No probes available for Shank1 on Affymetrix MOE430_2.0 GeneChip.
