GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms Semah
Chromosome 5
Genetic Map Distance 5.66 cM
RefSeq Accessions NM_011348; NP_035478
NCBI Entrez Gene 20349 at chr5:14025276-14256689 (mm9) / chr5:14025276-14256689 (mm10)
Ensembl Gene ENSMUSG00000063531
VEGA Gene OTTMUSG00000029684
MGI Gene MGI:1340034
Mouse Protein (5)
UniProt ID Description Length (AA) Predicted # TMs
P70275 Semaphorin-3E 775 0
Q6ZQD8 MKIAA0331 protein (Fragment) 574 0
Q8CCK6 MCG148351 131 0
Q8K4M3 Semaphorin H (Fragment) 61 0
Q9QX23 Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (Semaphorin) 3E 775 0
Pfam Domains Sema; PSI; ig
Mouse alleles (5)
Allele Name Allele Type
Sema3etm1a(EUCOMM)Wtsi EUCOMM-projects
Sema3etm1(KOMP)Vlcg KOMP-Regeneron-Project
Sema3eGt(OST204387)Lex Gene trapped
Sema3etm1(cre/ERT2)Arbr Targeted (knock-in)
Sema3etm1Ddg Targeted (Reporter)
Human Homolog SEMA3E (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E)
Human synonyms coll-5; M-SEMAH; M-SemaK; SEMAH
Human cytoband 7q21.11
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000008509 (SEM3E_CHICK) encoding ENSGALP00000013846
ENSGALG00000008509 (SEM3E_CHICK) encoding ENSGALP00000030121
Gene Ontology
Biological Process (12) multicellular organismal development; multicellular organismal development; cell differentiation; nervous system development; negative regulation of cell-matrix adhesion; sprouting angiogenesis; negative regulation of angiogenesis; regulation of cell shape; regulation of cell shape; semaphorin-plexin signaling pathway; regulation of actin cytoskeleton reorganization; patterning of blood vessels
Cellular Component (2) membrane; extracellular region
Molecular Function (1) receptor activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
3014
3024
1937
4075
2477
1143
Cochlea GFP+ cells
468
400
1473
552
347
NA
Utricle GFP- cells
703
475
184
240
495
409
Cochlea GFP- cells
138
440
189
48
68
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
308
GFP+
1719
5.57
0.0133
Utricle
1515
Cochlea
412
0.27
0.727
Embryonic
1083
Postnatal
974
0.90
0.982
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17434813 5.42 ± 0.60 5.81 ± 1.00 [7.88] 1.07 0.717
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
96
100
100
77
No bFGF
202
209
148
170
EGF
107
90
77
91
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
77
No bFGF
170
2.20
0.765
bFGF
77
EGF
91
1.18
0.487
No bFGF
170
EGF
91
0.54
6.0e-5
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1419717_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 409.01 1173.79 3741.29 3461.36 1102.79 145.54
Replicate 1 Call P P P P P P
Replicate 2 450.98 1070.13 2858.76 1638.63 2463.86 73.46
Replicate 2 Call P P P P P A
Replicate 3 453.12 1281.15 3408.87 3659.7 99.62 907.11
Replicate 3 Call P P P P A P
Replicate 4 2169.26 3809.9 46.84 1125.06
Replicate 4 Call P P A P
Mean 437.7 1175.02 3044.55 3142.4 928.28 562.79
Standard Deviation 24.87 105.52 687.71 1012.62 1133.15 531.74
Log2 Mean 8.77 10.19 11.54 11.54 8.39 8.34
Log2 Standard Deviation 0.08 0.13 0.35 0.58 2.73 1.94
 
Vestibular ganglion
Replicate 1 845.33 894.7 998.77 846.48 745.77 656.83
Replicate 1 Call P P P P P P
Replicate 2 834.09 1288.33 1090.44 1205.15 726.38 694.52
Replicate 2 Call P P P P P P
Replicate 3 759.99 1207.17 1474.9 965.74 904.5 656.25
Replicate 3 Call P P P P P P
Mean 813.14 1130.07 1188.04 1005.79 792.22 669.2
Standard Deviation 46.37 207.83 252.62 182.66 97.72 21.93
Log2 Mean 9.67 10.12 10.19 9.96 9.62 9.39
Log2 Standard Deviation 0.08 0.28 0.3 0.26 0.17 0.05
Probe set ID: 1425906_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 2.15 1 45.54 7.67 5.67 8.57
Replicate 1 Call A A P A A A
Replicate 2 3.92 1 17.87 2.64 6.61 1
Replicate 2 Call A A P A A A
Replicate 3 1.78 9.89 20.92 2.53 1 8.19
Replicate 3 Call A A P A A A
Replicate 4 4.42 5.89 1 1
Replicate 4 Call A A A A
Mean 2.62 3.96 22.19 4.68 3.57 4.69
Standard Deviation 1.14 5.13 17.14 2.53 2.99 4.26
Log2 Mean 1.3 1.1 4.05 2.06 1.31 1.53
Log2 Standard Deviation 0.59 1.91 1.4 0.81 1.51 1.77
 
Vestibular ganglion
Replicate 1 7.28 3.66 1 1 4.04 1
Replicate 1 Call A A A A A A
Replicate 2 4.81 1 1 1 1 3.86
Replicate 2 Call A A A A A A
Replicate 3 1 1 1 1 1 1
Replicate 3 Call A A A A A A
Mean 4.36 1.89 1 1 2.01 1.95
Standard Deviation 3.16 1.54 0 0 1.76 1.65
Log2 Mean 1.71 0.62 0 0 0.67 0.65
Log2 Standard Deviation 1.51 1.08 0 0 1.16 1.13
Probe set ID: 1427673_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 427.61 491.2 1038.03 822.38 439.19 450.67
Replicate 1 Call A P P P A A
Replicate 2 380.41 544.83 681.48 616.2 579.96 393.83
Replicate 2 Call A A P P P A
Replicate 3 325.08 483.24 770.21 788.93 391.13 515.67
Replicate 3 Call A P P P A A
Replicate 4 633.63 817.84 322.72 478.45
Replicate 4 Call P P A A
Mean 377.7 506.42 780.84 761.34 433.25 459.66
Standard Deviation 51.32 33.5 180.56 97.89 108.86 51.33
Log2 Mean 8.55 8.98 9.58 9.56 8.73 8.84
Log2 Standard Deviation 0.2 0.09 0.31 0.2 0.35 0.16
 
Vestibular ganglion
Replicate 1 476.85 410.79 456.36 433.23 339.02 392.94
Replicate 1 Call A A A A A A
Replicate 2 417.3 451.06 431.43 390.19 433.77 399.36
Replicate 2 Call A P A A A A
Replicate 3 464.16 488.93 445.9 419.28 434.2 350.75
Replicate 3 Call A A A A A P
Mean 452.77 450.26 444.56 414.23 402.33 381.02
Standard Deviation 31.37 39.08 12.52 21.96 54.83 26.41
Log2 Mean 8.82 8.81 8.8 8.69 8.64 8.57
Log2 Standard Deviation 0.1 0.13 0.04 0.08 0.21 0.1
Probe set ID: 1442226_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 2967.7 4565.54 7555.23 6980.59 4727.86 1050.25
Replicate 1 Call P P P P P P
Replicate 2 3047.24 5516.51 6354.26 6134.42 6532.52 1837.86
Replicate 2 Call P P P P P P
Replicate 3 3167.21 5589.83 6516.9 7293.62 554.6 4908.25
Replicate 3 Call P P P P P P
Replicate 4 5892.98 7753.24 81.78 4951.59
Replicate 4 Call P P A P
Mean 3060.72 5223.96 6579.84 7040.47 2974.19 3186.99
Standard Deviation 100.44 571.39 701.9 682.31 3160.04 2038.17
Log2 Mean 11.58 12.34 12.68 12.78 10.09 11.35
Log2 Standard Deviation 0.05 0.16 0.15 0.14 2.95 1.11
 
Vestibular ganglion
Replicate 1 5337.39 5415.73 3954.12 3919.33 3504.08 3967.72
Replicate 1 Call P P P P P P
Replicate 2 4979.2 5961.81 4413.34 4125.75 3291.73 3794.98
Replicate 2 Call P P P P P P
Replicate 3 4889.71 5675.66 4294.63 4170.71 3568.83 3760.27
Replicate 3 Call P P P P P P
Mean 5068.77 5684.4 4220.7 4071.93 3454.88 3840.99
Standard Deviation 236.9 273.14 238.37 134.05 144.95 111.12
Log2 Mean 12.31 12.47 12.04 11.99 11.75 11.91
Log2 Standard Deviation 0.07 0.07 0.08 0.05 0.06 0.04