GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description receptor tyrosine kinase-like orphan receptor 1
Synonyms 2810404D04Rik; Ntrkr1
Chromosome 4
Genetic Map Distance 45.71 cM
RefSeq Accessions NM_013845; NP_038873
NCBI Entrez Gene 26563 at chr4:99768396-100115150 (mm9) / chr4:100095791-100444765 (mm10)
Ensembl Gene ENSMUSG00000035305
VEGA Gene OTTMUSG00000008027
MGI Gene MGI:1347520
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
Q9Z139 Tyrosine-protein kinase transmembrane receptor ROR1 937 1
Q8BG10 Receptor tyrosine kinase-like orphan receptor 1 937 1
Q8BNP9 Putative uncharacterized protein 937 1
Q501P6 Ror1 protein 161 0
Pfam Domains I-set; Fz; Kringle; Pkinase_Tyr
Mouse alleles (4)
Allele Name Allele Type
Ror1tm1e(EUCOMM)Hmgu EUCOMM-projects
Ror1tm1a(EUCOMM)Hmgu EUCOMM-projects
Ror1tm1(NCOM)Mfgc NorCOMM-projects
Ror1tm1Ymi Targeted (knock-out)
Human Homolog ROR1 (receptor tyrosine kinase-like orphan receptor 1)
Human synonyms dJ537F10.1; NTRKR1
Human cytoband 1p32-p31
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000011019 (Q705C2_CHICK) encoding ENSGALP00000017932
Gene Ontology
Biological Process (4) phosphorylation; protein phosphorylation; protein phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component (3) integral to plasma membrane; integral to membrane; membrane
Molecular Function (12) kinase activity; nucleotide binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding; transferase activity; transferring phosphorus-containing groups; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ATP binding; receptor activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
43
3
10
11
3
45
Cochlea GFP+ cells
30
9
8
0
0
NA
Utricle GFP- cells
36
31
22
25
12
47
Cochlea GFP- cells
22
10
12
16
6
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
22
GFP+
15
0.68
0.79
Utricle
24
Cochlea
11
0.47
1
Embryonic
23
Postnatal
15
0.68
0.743
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17415835 7.53 ± 0.55 8.47 ± 1.26 [7.69] 1.13 0.662
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
22
18
39
41
No bFGF
27
43
45
36
EGF
69
53
58
60
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
41
No bFGF
36
0.89
1
bFGF
41
EGF
60
1.46
0.112
No bFGF
36
EGF
60
1.64
0.036
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000017932
Symbol ROR1
Description Receptor tyrosine kinase-like orphan receptor 1
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -6.01 ± ND
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1429312_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 35.94 14.74 26.24 14.18 13.42 15.42
Replicate 1 Call A A A A A A
Replicate 2 37.66 17.43 23.36 11.47 18.52 13.8
Replicate 2 Call A A A A A A
Replicate 3 17.74 14.18 25.05 21.25 8.96 22.87
Replicate 3 Call A A A A A A
Replicate 4 18.22 21.63 8.31 26.86
Replicate 4 Call A A A A
Mean 30.45 15.45 23.22 17.13 12.3 19.74
Standard Deviation 11.04 1.74 3.54 5.1 4.73 6.18
Log2 Mean 4.85 3.94 4.52 4.05 3.54 4.25
Log2 Standard Deviation 0.61 0.16 0.23 0.45 0.54 0.46
 
Vestibular ganglion
Replicate 1 25.64 17.52 19.58 21 17.13 24.45
Replicate 1 Call A A A A A A
Replicate 2 23.48 12.46 20.02 24.71 15.56 16.3
Replicate 2 Call A A A A A A
Replicate 3 11.53 30.48 11.7 18.07 28.47 20.52
Replicate 3 Call A A A A A A
Mean 20.22 20.15 17.1 21.26 20.39 20.42
Standard Deviation 7.6 9.29 4.68 3.33 7.04 4.08
Log2 Mean 4.25 4.23 4.05 4.4 4.3 4.33
Log2 Standard Deviation 0.63 0.65 0.44 0.23 0.47 0.29
Probe set ID: 1429313_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1354.71 422.28 89.66 158.23 444.57 999.61
Replicate 1 Call P P A P P P
Replicate 2 1557.58 480.4 116.3 483.33 279.3 481.88
Replicate 2 Call P P P P P P
Replicate 3 1671.1 548.92 96.07 81.91 860.93 365.12
Replicate 3 Call P P A A P P
Replicate 4 126.52 85.5 673.74 253.46
Replicate 4 Call P A P P
Mean 1527.8 483.87 107.14 202.24 564.64 525.02
Standard Deviation 160.28 63.39 17.2 190.66 255.29 329.85
Log2 Mean 10.57 8.91 6.73 7.25 9.02 8.84
Log2 Standard Deviation 0.15 0.19 0.23 1.19 0.71 0.84
 
Vestibular ganglion
Replicate 1 334.7 229.18 1072.54 559.99 476.81 453.29
Replicate 1 Call P P P P P P
Replicate 2 306.17 257.65 846.49 610.66 531.24 444.46
Replicate 2 Call P P P P P P
Replicate 3 289.57 225.48 829.85 395.82 706.53 565.49
Replicate 3 Call P P P P P P
Mean 310.15 237.44 916.29 522.16 571.53 487.75
Standard Deviation 22.83 17.6 135.57 112.31 120.04 67.47
Log2 Mean 8.27 7.89 9.83 9 9.14 8.92
Log2 Standard Deviation 0.11 0.1 0.21 0.33 0.29 0.19
Probe set ID: 1451014_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 42.61 27.39 27.56 20.64 22.99 29.66
Replicate 1 Call A A A A A A
Replicate 2 28.3 37.23 46.55 23.7 15.7 2.2
Replicate 2 Call A P A A A A
Replicate 3 20.28 31.52 26.09 28.93 21.53 16.73
Replicate 3 Call A A A A A A
Replicate 4 54.81 7.87 12.55 19.33
Replicate 4 Call A A A A
Mean 30.4 32.05 38.75 20.29 18.19 16.98
Standard Deviation 11.31 4.94 14.19 8.96 4.91 11.33
Log2 Mean 4.86 4.99 5.2 4.19 4.14 3.59
Log2 Standard Deviation 0.54 0.22 0.54 0.83 0.41 1.67
 
Vestibular ganglion
Replicate 1 13.19 20.5 39.09 20.75 34.63 27.13
Replicate 1 Call A A A A A A
Replicate 2 35.9 10.06 9.33 6.82 24.06 18.45
Replicate 2 Call A A A A A P
Replicate 3 33.32 9.49 18.21 2.5 36.82 17.42
Replicate 3 Call A P A A A P
Mean 27.47 13.35 22.21 10.02 31.84 21
Standard Deviation 12.43 6.2 15.28 9.54 6.82 5.33
Log2 Mean 4.65 3.64 4.23 2.82 4.97 4.36
Log2 Standard Deviation 0.8 0.62 1.03 1.53 0.33 0.35