GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description protein tyrosine phosphatase, receptor type, Q
Synonyms
Chromosome 10
Genetic Map Distance 55.97 cM
RefSeq Accessions NM_001081432; NP_001074901; XM_137234
NCBI Entrez Gene 237523 at chr10:106954416-107157083 (mm9) / chr10:107514778-107720078 (mm10)
Ensembl Gene ENSMUSG00000035916
VEGA Gene
MGI Gene MGI:1096349
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
P0C5E4 Phosphotidylinositol phosphatase PTPRQ 2300 1
Q8BY76 Putative uncharacterized protein (Fragment) 1086 1
O88570 Protein tyrosine phosphatase rPTP-GMC1 (Fragment) 24 0
Q9ERZ2 Protein tyrosine phosphatase RPTP-GMC1 (Fragment) 17 0
Pfam Domains fn3; Pfam-B_2000; fn3; fn3; fn3; Pfam-B_2000; fn3; Pfam-B_2000; fn3; fn3; Pfam-B_2000; fn3; fn3; Pfam-B_2000; fn3; fn3; fn3; Pfam-B_2000; fn3; Pfam-B_2000; fn3; fn3; Pfam-B_2000; fn3; fn3; Pfam-B_18406; Y_phosphatase
Mouse alleles (3)
Allele Name Allele Type
Ptprqtm1a(EUCOMM)Hmgu EUCOMM-projects
Ptprqtm1Bow Targeted (knock-out)
Ptprqtm2Bow Targeted (knock-out)
Human Homolog PTPRQ (protein tyrosine phosphatase, receptor type, Q)
Human synonyms DFNB84; PTPGMC1; R-PTP-Q
Human cytoband 12q21.2
Known deafness gene DFNB84A
Within mapped deafness loci DFNA25
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000010935 (PTPRQ) encoding ENSGALP00000017773
ENSGALG00000010935 (PTPRQ) encoding ENSGALP00000037632
Gene Ontology
Biological Process (6) peptidyl-tyrosine dephosphorylation; peptidyl-tyrosine dephosphorylation; inner ear morphogenesis; dephosphorylation; protein dephosphorylation; regulation of fat cell differentiation
Cellular Component (3) integral to membrane; membrane; cellular_component
Molecular Function (6) phosphatase activity; hydrolase activity; receptor activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
459
325
1318
5213
4866
4850
Cochlea GFP+ cells
128
47
1176
3034
1966
NA
Utricle GFP- cells
2
42
2
15
18
94
Cochlea GFP- cells
3
9
2
1
2
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
17
GFP+
2126
119.38
1.51e-18
Utricle
1434
Cochlea
637
0.44
1
Embryonic
127
Postnatal
1611
12.65
9.57e-7
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17244737 1067.52 ± 46.84 844.44 ± 156.19 [487.88] 0.79 0.24
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
0
0
0
No bFGF
2
2
0
1
EGF
0
1
1
1
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
0
No bFGF
1
1.26
1
bFGF
0
EGF
1
1.47
0.896
No bFGF
1
EGF
1
1.17
1
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000017773
Symbol PTPRQ
Description Protein tyrosine phosphatase, receptor type, Q
log10 riBAQ in stereocilia (mean ± sd) -2.97 ± 0.11
log10 riBAQ in utricle (mean ± sd) -3.46 ± 0.10
Molecules per stereocilium (mean ± error with slope error) 1594.15 ± 74.51
Corrected Molecules per stereocilium (mean ± sd) 1536.68 ± 201.48
Stereocilium / Utricle ratio (mean ± sd) 3.14 ± 0.20
Enriched in the stereocilia (FDR < 0.05) TRUE
Protein ID ENSGALP00000017773
Symbol PTPRQ
Description Protein tyrosine phosphatase, receptor type, Q
log10 riBAQ in stereocilia (mean ± sd) -4.98 ± ND
log10 riBAQ in utricle (mean ± sd) ND
Molecules per stereocilium (mean ± error with slope error) 15.28 ± ND
Corrected Molecules per stereocilium (mean ± sd) 15.73 ± ND
Stereocilium / Utricle ratio (mean ± sd) BUN only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
No probes available for Ptprq on Affymetrix MOE430_2.0 GeneChip.