GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description phosphoribosyl pyrophosphate synthetase 1
Synonyms Prps-1; 2310010D17Rik
Chromosome X
Genetic Map Distance 61.35 cM
RefSeq Accessions NM_021463; NP_067438
NCBI Entrez Gene 19139 at chrX:136991142-137010679 (mm9) / chr0:140456603-140476140 (mm10)
Ensembl Gene ENSMUSG00000031432
VEGA Gene OTTMUSG00000018847
MGI Gene MGI:97775
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
Q9D7G0 Ribose-phosphate pyrophosphokinase 1 318 0
Q3TI27 Putative uncharacterized protein 318 0
Q3UPD5 Putative uncharacterized protein 318 0
Q76MX9 Phosphoribosyl pyrophosphate synthetase 1 318 0
Pfam Domains
Mouse alleles (4)
Allele Name Allele Type
Prps1tm1e(EUCOMM)Wtsi EUCOMM-projects
Prps1tm2e(EUCOMM)Wtsi EUCOMM-projects
Prps1tm1a(EUCOMM)Wtsi EUCOMM-projects
Prps1Gt(OST413819)Lex Gene trapped
Human Homolog PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Human synonyms ARTS; CMTX5; DFN2; DFNX1; PPRibP; PRS-I; PRSI
Human cytoband Xq21.32-q24
Known deafness gene DFNX1/ARTS
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000004908 (PRPS1) encoding ENSGALP00000007837
Gene Ontology
Biological Process (13) phosphorylation; purine base metabolic process; purine nucleotide biosynthetic process; nervous system development; urate biosynthetic process; hypoxanthine biosynthetic process; ribonucleoside monophosphate biosynthetic process; nucleoside metabolic process; cellular biosynthetic process; 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; nucleotide biosynthetic process; ribose phosphate metabolic process
Cellular Component (3) soluble fraction; ribose phosphate diphosphokinase complex; protein complex
Molecular Function (14) transferase activity; kinase activity; ATP binding; ATP binding; metal ion binding; protein homodimerization activity; sugar binding; AMP binding; GDP binding; ADP binding; ribose phosphate diphosphokinase activity; ribose phosphate diphosphokinase activity; magnesium ion binding; nucleotide binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
446
571
675
852
879
1425
Cochlea GFP+ cells
491
566
750
753
476
NA
Utricle GFP- cells
577
501
419
725
262
456
Cochlea GFP- cells
565
476
305
477
554
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
483
GFP+
717
1.48
0.834
Utricle
649
Cochlea
541
0.83
1
Embryonic
524
Postnatal
643
1.23
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17538161 103.65 ± 4.25 129.29 ± 35.50 [65.49] 1.25 0.55
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1037
1136
1146
1018
No bFGF
825
745
785
811
EGF
1142
1221
1228
1197
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1018
No bFGF
811
0.80
1
bFGF
1018
EGF
1197
1.18
0.206
No bFGF
811
EGF
1197
1.48
0.000809
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000007837
Symbol PRPS1L1
Description Phosphoribosyl pyrophosphate synthetase 1-like 1
log10 riBAQ in stereocilia (mean ± sd) -4.13 ± 0.25
log10 riBAQ in utricle (mean ± sd) -4.07 ± 0.24
Molecules per stereocilium (mean ± error with slope error) 109.33 ± 7.41
Corrected Molecules per stereocilium (mean ± sd) 86.65 ± 38.89
Stereocilium / Utricle ratio (mean ± sd) 0.87 ± 0.08
Enriched in the stereocilia (FDR < 0.05) TRUE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416052_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1362.36 1558.16 1608.2 2118.18 1904.63 1167.45
Replicate 1 Call P P P P P P
Replicate 2 1548.39 1911.4 1070.11 1858.06 1968.12 1144
Replicate 2 Call P P P P P P
Replicate 3 1605.52 1865.02 1332.95 2155.72 1717.14 1385.52
Replicate 3 Call P P P P P P
Replicate 4 751.67 2132.64 1385.09 1303.24
Replicate 4 Call P P P P
Mean 1505.42 1778.19 1190.73 2066.15 1743.75 1250.05
Standard Deviation 127.15 191.96 365.98 139.59 261.77 114.38
Log2 Mean 10.55 10.79 10.16 11.01 10.75 10.28
Log2 Standard Deviation 0.12 0.16 0.47 0.1 0.23 0.13
 
Vestibular ganglion
Replicate 1 1542.06 2045.6 1996.69 2190.41 2322.37 1945.45
Replicate 1 Call P P P P P P
Replicate 2 1525.35 2195.27 1999.47 1943.79 2204.22 2181.98
Replicate 2 Call P P P P P P
Replicate 3 1535.8 2044.55 1929.39 2294.43 2286.6 2420.59
Replicate 3 Call P P P P P P
Mean 1534.4 2095.14 1975.18 2142.88 2271.06 2182.67
Standard Deviation 8.44 86.72 39.68 180.09 60.59 237.57
Log2 Mean 10.58 11.03 10.95 11.06 11.15 11.09
Log2 Standard Deviation 0.01 0.06 0.03 0.12 0.04 0.16
Probe set ID: 1448192_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 174.24 278.56 171.63 129.45 154.43 87.6
Replicate 1 Call P P P P P A
Replicate 2 173.44 336.12 41.94 165.68 144.02 359.67
Replicate 2 Call P P P P P P
Replicate 3 179.29 395.54 26.16 51.31 116.39 70.61
Replicate 3 Call P P A P P P
Replicate 4 43.32 118.06 96.07 87.6
Replicate 4 Call A P P P
Mean 175.66 336.74 70.76 116.13 127.73 151.37
Standard Deviation 3.17 58.49 67.69 47.74 26.52 139.1
Log2 Mean 7.46 8.38 5.74 6.74 6.97 6.88
Log2 Standard Deviation 0.03 0.25 1.17 0.73 0.31 1.08
 
Vestibular ganglion
Replicate 1 134.43 256.25 122.13 123.41 136.59 421.17
Replicate 1 Call P P P P P P
Replicate 2 152.52 362.94 165.09 52.95 154.39 602.12
Replicate 2 Call P P P A P P
Replicate 3 87.92 305.77 139.08 114.17 190 558.14
Replicate 3 Call P P P P P P
Mean 124.96 308.32 142.1 96.84 160.33 527.14
Standard Deviation 33.33 53.39 21.64 38.29 27.2 94.37
Log2 Mean 6.93 8.25 7.14 6.5 7.31 9.03
Log2 Standard Deviation 0.42 0.25 0.22 0.67 0.24 0.27