GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description protoporphyrinogen oxidase
Synonyms
Chromosome 1
Genetic Map Distance 79.30 cM
RefSeq Accessions NM_008911; NP_032937
NCBI Entrez Gene 19044 at chr1:173207123-173211317 (mm9) / chr1:171276992-171281186 (mm10)
Ensembl Gene ENSMUSG00000062729
VEGA Gene OTTMUSG00000021555
MGI Gene MGI:104968
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
P51175 Protoporphyrinogen oxidase 477 0
Q3UQA3 Putative uncharacterized protein 477 0
Q6LC38 Protoporhyrinogen oxidase (Fragment) 49 0
Pfam Domains Pfam-B_14620; Amino_oxidase; Pfam-B_15480
Mouse alleles (1)
Allele Name Allele Type
Ppoxtm1(KOMP)Mbp KOMP-CSD-Project
Human Homolog PPOX (protoporphyrinogen oxidase)
Human synonyms PPO; V290M; VP
Human cytoband 1q22
Known deafness gene No
Within mapped deafness loci DFNA7; DFNA49
Associated Human Disease in OMIM
Chicken homolog (0)
Gene Ontology
Biological Process (7) porphyrin-containing compound biosynthetic process; porphyrin-containing compound biosynthetic process; protoporphyrinogen IX metabolic process; oxidation-reduction process; heme biosynthetic process; heme biosynthetic process; heme biosynthetic process
Cellular Component (8) mitochondrial inner membrane; mitochondrial membrane; membrane; intrinsic to mitochondrial inner membrane; integral to mitochondrial inner membrane; mitochondrion; mitochondrion; mitochondrion
Molecular Function (6) oxygen-dependent protoporphyrinogen oxidase activity; oxygen-dependent protoporphyrinogen oxidase activity; oxygen-dependent protoporphyrinogen oxidase activity; nucleotide binding; oxidoreductase activity; oxidoreductase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
13
0
3
2
7
32
Cochlea GFP+ cells
8
7
4
18
20
NA
Utricle GFP- cells
13
10
0
15
64
15
Cochlea GFP- cells
9
3
6
39
17
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
17
GFP+
10
0.60
0.805
Utricle
14
Cochlea
13
0.90
1
Embryonic
8
Postnatal
17
2.15
0.984
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17229681 55.33 ± 6.50 44.75 ± 4.07 [48.62] 0.81 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
814
885
899
827
No bFGF
871
969
953
846
EGF
285
350
300
312
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
827
No bFGF
846
1.02
1
bFGF
827
EGF
312
0.38
1.09e-19
No bFGF
846
EGF
312
0.37
9.14e-21
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Ppox.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1416618_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 238.78 154.58 315.09 263.45 269.57 512.45
Replicate 1 Call A A P A P P
Replicate 2 241.59 226.7 393.46 268.4 228.63 310.91
Replicate 2 Call A P P A A M
Replicate 3 202.63 228.89 275.46 252.41 305.32 142.68
Replicate 3 Call A P P A P A
Replicate 4 337.79 200.1 363.4 234.6
Replicate 4 Call P A P P
Mean 227.67 203.39 330.45 246.09 291.73 300.16
Standard Deviation 21.73 42.28 49.27 31.38 57.14 157.35
Log2 Mean 7.83 7.65 8.36 7.93 8.17 8.08
Log2 Standard Deviation 0.14 0.32 0.21 0.2 0.28 0.77
 
Vestibular ganglion
Replicate 1 260.06 232.9 135.58 64.46 127.3 161.78
Replicate 1 Call A P A A A A
Replicate 2 233.35 223.48 105.29 135.41 141.87 162.65
Replicate 2 Call A A A A A A
Replicate 3 245.13 190.89 80 138.08 152.14 190.47
Replicate 3 Call A M A A A A
Mean 246.18 215.76 106.96 112.65 140.44 171.63
Standard Deviation 13.39 22.04 27.83 41.76 12.48 16.32
Log2 Mean 7.94 7.75 6.71 6.73 7.13 7.42
Log2 Standard Deviation 0.08 0.15 0.38 0.63 0.13 0.13
Probe set ID: 1441862_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 146 93.54 153.38 140.78 104.98 186.94
Replicate 1 Call A A A A A A
Replicate 2 140.67 134.91 224.68 211.26 164.86 245.92
Replicate 2 Call A P A A A A
Replicate 3 171.52 99.86 146.09 174.97 149.09 174.39
Replicate 3 Call A P A A A A
Replicate 4 163.13 134.8 205.32 266
Replicate 4 Call A A P A
Mean 152.73 109.44 171.82 165.45 156.06 218.31
Standard Deviation 16.49 22.29 35.92 35.3 41.48 44.53
Log2 Mean 7.25 6.76 7.4 7.35 7.25 7.75
Log2 Standard Deviation 0.15 0.28 0.28 0.3 0.4 0.3
 
Vestibular ganglion
Replicate 1 170.84 163.04 301.73 264.96 266.62 94.82
Replicate 1 Call A A A A A A
Replicate 2 173.14 175.51 195.13 279.4 216.25 106.51
Replicate 2 Call A A A A A A
Replicate 3 177.02 146.2 272.84 259 198.96 110.26
Replicate 3 Call A P A A A A
Mean 173.67 161.58 256.57 267.79 227.28 103.86
Standard Deviation 3.12 14.71 55.13 10.49 35.15 8.05
Log2 Mean 7.44 7.33 7.98 8.06 7.82 6.7
Log2 Standard Deviation 0.03 0.13 0.33 0.06 0.22 0.11
Probe set ID: 1448065_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 161.82 300.49 531.3 382.83 450.02 1106.25
Replicate 1 Call A P P P P P
Replicate 2 165.47 284.87 646.28 392.33 452.3 474.15
Replicate 2 Call A P P M A A
Replicate 3 152.23 428.76 473.44 273.81 712.46 557.15
Replicate 3 Call A P P A P M
Replicate 4 912.81 354.87 721.31 608.78
Replicate 4 Call P P A P
Mean 159.84 338.04 640.96 350.96 584.02 686.58
Standard Deviation 6.84 78.95 194.95 53.83 153.46 285.22
Log2 Mean 7.32 8.38 9.28 8.44 9.15 9.34
Log2 Standard Deviation 0.06 0.32 0.41 0.24 0.39 0.53
 
Vestibular ganglion
Replicate 1 185.73 415.42 225.64 189.79 211.92 192.25
Replicate 1 Call A P A A A P
Replicate 2 176.85 312.03 305.86 280.84 261.13 242.01
Replicate 2 Call A P A A A P
Replicate 3 185.53 488.26 179.95 275.31 303.3 235.45
Replicate 3 Call A P A A A A
Mean 182.7 405.24 237.15 248.65 258.78 223.24
Standard Deviation 5.07 88.56 63.74 51.05 45.74 27.03
Log2 Mean 7.51 8.64 7.86 7.94 8 7.8
Log2 Standard Deviation 0.04 0.33 0.38 0.32 0.26 0.18