GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description polymerase (RNA) I polypeptide C
Synonyms Rpo1-1; 40kDa; RPA40
Chromosome 17
Genetic Map Distance 22.90 cM
RefSeq Accessions NM_009085; NP_033111
NCBI Entrez Gene 20016 at chr17:46380869-46384994 (mm9) / chr17:46243920-46248045 (mm10)
Ensembl Gene ENSMUSG00000067148
VEGA Gene OTTMUSG00000028872
MGI Gene MGI:103288
Mouse Protein (5)
UniProt ID Description Length (AA) Predicted # TMs
P52432 DNA-directed RNA polymerases I and III subunit RPAC1 346 0
A1L3C2 Polr1c protein 347 0
D3Z3D6 Uncharacterized protein 260 0
D3Z7Q8 Uncharacterized protein 269 0
Q3UJZ9 Putative uncharacterized protein 346 0
Pfam Domains RNA_pol_L; RNA_pol_A_bac
Mouse alleles (2)
Allele Name Allele Type
Polr1ctm1a(KOMP)Wtsi KOMP-CSD-Project
Polr1ctm1e(KOMP)Wtsi KOMP-CSD-Project
Human Homolog POLR1C (polymerase (RNA) I polypeptide C, 30kDa)
Human synonyms RPA39; RPA40; RPA5; RPAC1; TCS3
Human cytoband 6p21.1
Known deafness gene No
Within mapped deafness loci DFNA21
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000010349 (POLR1C) encoding ENSGALP00000016829
Gene Ontology
Biological Process (2) transcription; DNA-dependent; transcription; DNA-dependent
Cellular Component (1) nucleus
Molecular Function (4) protein dimerization activity; DNA-directed RNA polymerase activity; DNA-directed RNA polymerase activity; DNA binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
1834
64
211
203
224
352
Cochlea GFP+ cells
276
126
139
238
356
NA
Utricle GFP- cells
237
82
59
116
98
0
Cochlea GFP- cells
209
104
58
192
172
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
121
GFP+
366
3.02
0.776
Utricle
290
Cochlea
187
0.65
1
Embryonic
367
Postnatal
173
0.47
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17345335 145.52 ± 0.63 188.25 ± 82.18 [53.07] 1.29 0.765
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
3410
3290
3466
3093
No bFGF
3287
3416
3207
3212
EGF
2981
3246
3270
3166
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
3093
No bFGF
3212
1.04
1
bFGF
3093
EGF
3166
1.02
0.911
No bFGF
3212
EGF
3166
0.99
1
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1417041_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1396.09 1315.79 838.6 701.68 1295.17 772.73
Replicate 1 Call P P P P P P
Replicate 2 1503 1400.92 576.09 716.21 940.92 759.22
Replicate 2 Call P P A P P P
Replicate 3 1608.19 1508.75 776.77 645.48 1516.99 472.5
Replicate 3 Call P P P P P P
Replicate 4 607.08 859.25 1089.85 457.46
Replicate 4 Call P P P P
Mean 1502.43 1408.49 699.64 730.66 1210.73 615.48
Standard Deviation 106.05 96.7 127.92 90.99 250.56 173.98
Log2 Mean 10.55 10.46 9.43 9.51 10.22 9.22
Log2 Standard Deviation 0.1 0.1 0.26 0.17 0.3 0.42
 
Vestibular ganglion
Replicate 1 1319.27 1638.95 1317.11 1059.2 1017.85 847.52
Replicate 1 Call P P P P P A
Replicate 2 1204.76 1665.51 1193.04 650.03 983.23 1081.37
Replicate 2 Call P P P P P P
Replicate 3 1253.57 1627.3 1129.98 1006.57 1063.65 1108.08
Replicate 3 Call P P P P P P
Mean 1259.2 1643.92 1213.38 905.27 1021.58 1012.32
Standard Deviation 57.46 19.58 95.21 222.6 40.34 143.35
Log2 Mean 10.3 10.68 10.24 9.79 10 9.97
Log2 Standard Deviation 0.07 0.02 0.11 0.39 0.06 0.21
Probe set ID: 1449648_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 3377.34 2823.48 3065.82 2672.77 3518.42 3137.71
Replicate 1 Call P P P P P P
Replicate 2 3554.57 3678.84 2671.51 2734.99 2875.1 3689.73
Replicate 2 Call P P P P P P
Replicate 3 3684.54 3598.36 2938.98 2537.63 3679.41 2508.91
Replicate 3 Call P P P P P P
Replicate 4 2802.85 2651.48 2928.73 2328.34
Replicate 4 Call P P P P
Mean 3538.82 3366.89 2869.79 2649.22 3250.42 2916.17
Standard Deviation 154.2 472.33 170.3 82.4 408.33 621.52
Log2 Mean 11.79 11.71 11.48 11.37 11.66 11.49
Log2 Standard Deviation 0.06 0.21 0.09 0.05 0.18 0.3
 
Vestibular ganglion
Replicate 1 3264.99 3527.57 2978.17 2865.14 2633.99 2354.26
Replicate 1 Call P P P P P P
Replicate 2 3272.63 3840 2866.41 2323.92 2975.15 2741.24
Replicate 2 Call P P P P P P
Replicate 3 3286.5 3566.87 3147.97 2413.5 2551.52 2571.79
Replicate 3 Call P P P P P P
Mean 3274.71 3644.81 2997.52 2534.19 2720.22 2555.76
Standard Deviation 10.9 170.17 141.77 290.09 224.59 193.99
Log2 Mean 11.68 11.83 11.55 11.3 11.41 11.32
Log2 Standard Deviation 0 0.07 0.07 0.16 0.12 0.11