GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description peroxisomal biogenesis factor 6
Synonyms D130055I09Rik
Chromosome 17
Genetic Map Distance 22.90 cM
RefSeq Accessions NM_145488; NP_663463
NCBI Entrez Gene 224824 at chr17:46848412-46862490 (mm9) / chr17:46711463-46725541 (mm10)
Ensembl Gene ENSMUSG00000002763
VEGA Gene OTTMUSG00000026320
MGI Gene MGI:2385054
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
Q99LC9 Peroxisome assembly factor 2 981 0
A9C490 Peroxisomal biogenesis factor 6 981 0
Q5DTJ5 MKIAA4177 protein (Fragment) 796 0
Q8BJH7 Putative uncharacterized protein 417 0
Pfam Domains AAA; AAA; Vps4_C
Mouse alleles (2)
Allele Name Allele Type
Pex6tm1a(EUCOMM)Wtsi EUCOMM-projects
Pex6tm1(KOMP)Vlcg KOMP-Regeneron-Project
Human Homolog PEX6 (peroxisomal biogenesis factor 6)
Human synonyms PAF-2; PAF2; PXAAA1
Human cytoband 6p21.1
Known deafness gene No
Within mapped deafness loci DFNA21
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000008571 (PEX6) encoding ENSGALP00000013944
Gene Ontology
Biological Process (7) ATP catabolic process; protein targeting to peroxisome; peroxisome organization; peroxisome organization; protein import into peroxisome matrix; translocation; protein stabilization; metabolic process
Cellular Component (5) peroxisome; cytosol; peroxisomal membrane; membrane; cytoplasm
Molecular Function (9) protein C-terminus binding; ATPase activity; protein binding; protein complex binding; ATPase activity; coupled; ATP binding; nucleoside-triphosphatase activity; nucleotide binding; nucleotide binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
0
0
11
20
26
Cochlea GFP+ cells
5
11
11
37
51
NA
Utricle GFP- cells
28
11
9
5
60
0
Cochlea GFP- cells
11
19
0
22
38
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
18
GFP+
16
0.86
0.97
Utricle
14
Cochlea
20
1.41
1
Embryonic
11
Postnatal
21
1.82
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17338174 51.81 ± 9.76 44.22 ± 6.86 [35.52] 0.85 0.657
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
959
1069
1362
1483
No bFGF
995
1204
1451
1450
EGF
567
650
825
681
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1483
No bFGF
1450
0.98
1
bFGF
1483
EGF
681
0.46
3.4e-15
No bFGF
1450
EGF
681
0.47
9.01e-15
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1424078_s_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 161.06 131.44 627.4 515.56 378.24 1055.77
Replicate 1 Call A P P P P P
Replicate 2 146.95 172.28 783.33 531.91 590.68 439.43
Replicate 2 Call A P P P P P
Replicate 3 139.62 198.69 755.83 649.16 505.47 551.85
Replicate 3 Call A P P P P P
Replicate 4 585.47 465.79 435.62 532.22
Replicate 4 Call P P P P
Mean 149.21 167.47 688.01 540.61 477.5 644.82
Standard Deviation 10.9 33.88 96.39 77.64 91.65 278.32
Log2 Mean 7.22 7.37 9.42 9.07 8.88 9.25
Log2 Standard Deviation 0.1 0.3 0.2 0.2 0.28 0.55
 
Vestibular ganglion
Replicate 1 228.45 441.29 196.75 157.22 149.85 154.99
Replicate 1 Call M P A A A P
Replicate 2 204.02 354.62 162.19 166.65 125.16 204.1
Replicate 2 Call P P A A A P
Replicate 3 218.13 363.41 130.73 167.69 159.91 169.37
Replicate 3 Call P P A A A P
Mean 216.87 386.44 163.22 163.85 144.97 176.15
Standard Deviation 12.26 47.7 33.02 5.77 17.88 25.25
Log2 Mean 7.76 8.59 7.33 7.36 7.17 7.45
Log2 Standard Deviation 0.08 0.17 0.3 0.05 0.18 0.2
Probe set ID: 1438138_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 367.87 436.74 690.41 845.74 1310.49 1899.37
Replicate 1 Call P P P P P P
Replicate 2 359.33 432.64 764.77 1231.74 917.87 2303.39
Replicate 2 Call A P P P P P
Replicate 3 361.29 318.63 932.79 753.86 1019.11 1460.35
Replicate 3 Call P P P P P P
Replicate 4 1119.87 800.21 1474.84 1301.16
Replicate 4 Call P P P P
Mean 362.83 396 876.96 907.89 1180.58 1741.07
Standard Deviation 4.47 67.04 191.06 219.14 257.26 452.25
Log2 Mean 8.5 8.61 9.75 9.8 10.18 10.73
Log2 Standard Deviation 0.02 0.26 0.31 0.32 0.32 0.37
 
Vestibular ganglion
Replicate 1 363.4 490.51 544.72 416.52 608.21 485.47
Replicate 1 Call M P P P P P
Replicate 2 415.83 498.01 479.81 581.47 441.39 609.53
Replicate 2 Call P P P P P P
Replicate 3 422.83 501.61 435.62 556.32 508.85 517.19
Replicate 3 Call P P P P P P
Mean 400.69 496.71 486.72 518.1 519.48 537.4
Standard Deviation 32.48 5.66 54.88 88.87 83.92 64.45
Log2 Mean 8.64 8.96 8.92 9 9.01 9.06
Log2 Standard Deviation 0.12 0.02 0.16 0.26 0.23 0.17
Probe set ID: 1451226_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 346.88 512.06 608.59 577.1 627.17 845.72
Replicate 1 Call A A P A A P
Replicate 2 369.25 455.73 745.41 593.34 608.01 677.25
Replicate 2 Call A A P A A A
Replicate 3 307.17 415.09 727.22 592.77 514.25 606.48
Replicate 3 Call A A P P A P
Replicate 4 648.74 538.2 609.85 638.86
Replicate 4 Call P A A A
Mean 341.1 460.96 682.49 575.35 589.82 692.08
Standard Deviation 31.44 48.7 64.7 25.89 51.11 106.43
Log2 Mean 8.41 8.84 9.41 9.17 9.2 9.42
Log2 Standard Deviation 0.14 0.15 0.14 0.07 0.13 0.21
 
Vestibular ganglion
Replicate 1 332.52 481.58 354.1 285.59 337.95 402.46
Replicate 1 Call A P A A A A
Replicate 2 280.87 447.97 393.1 337.65 293.24 391.92
Replicate 2 Call A P A A A A
Replicate 3 353.03 446.53 314.5 339.95 418.23 318.06
Replicate 3 Call A P A A A A
Mean 322.14 458.69 353.9 321.06 349.81 370.81
Standard Deviation 37.18 19.83 39.3 30.74 63.33 45.99
Log2 Mean 8.32 8.84 8.46 8.32 8.43 8.53
Log2 Standard Deviation 0.17 0.06 0.16 0.14 0.26 0.19
Probe set ID: 1454738_x_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 894.27 1131.95 2154.12 2074.61 1549.16 3062.03
Replicate 1 Call P P P P P P
Replicate 2 947.24 1225.04 3082.03 1683.07 1661.67 1973.76
Replicate 2 Call P P P P P P
Replicate 3 729.14 1279.66 3014.21 2288.06 1595.42 1796.2
Replicate 3 Call P P P P P P
Replicate 4 2813.66 1791.25 1472.93 1976.78
Replicate 4 Call P P P P
Mean 856.88 1212.22 2766.01 1959.25 1569.8 2202.19
Standard Deviation 113.76 74.69 423.54 274.42 79.39 579.41
Log2 Mean 9.73 10.24 11.42 10.93 10.61 11.07
Log2 Standard Deviation 0.2 0.09 0.24 0.2 0.07 0.35
 
Vestibular ganglion
Replicate 1 841.57 1706.1 934.15 769.91 552.97 770.86
Replicate 1 Call P P P P P P
Replicate 2 861.72 1661.98 1069.17 883.07 749.71 787.9
Replicate 2 Call P P P P P P
Replicate 3 780.09 1804.4 808.35 945.11 654.5 874.31
Replicate 3 Call P P P P P P
Mean 827.79 1724.16 937.22 866.03 652.39 811.02
Standard Deviation 42.52 72.91 130.44 88.83 98.39 55.47
Log2 Mean 9.69 10.75 9.86 9.75 9.34 9.66
Log2 Standard Deviation 0.08 0.06 0.2 0.15 0.22 0.1
Probe set ID: 1456302_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 843.19 1141.66 1104.81 1116.74 599.72 708.34
Replicate 1 Call P P P P P P
Replicate 2 913.96 1280.21 799.28 575.01 1070.68 615.65
Replicate 2 Call P P P P P P
Replicate 3 1011.59 1161.26 807.04 1167.72 763.42 901.88
Replicate 3 Call P P P P P P
Replicate 4 584.94 1066.22 499.32 853.02
Replicate 4 Call P P P P
Mean 922.91 1194.38 824.02 981.42 733.29 769.72
Standard Deviation 84.56 74.98 213.62 274.09 249.88 131.54
Log2 Mean 9.85 10.22 9.65 9.89 9.46 9.57
Log2 Standard Deviation 0.13 0.09 0.37 0.48 0.48 0.25
 
Vestibular ganglion
Replicate 1 1046.46 1023.59 889.29 1556.14 1615.21 1149.31
Replicate 1 Call P P P P P P
Replicate 2 1026.09 1281.14 945.85 1561.21 1677.83 1434.69
Replicate 2 Call P P P P P P
Replicate 3 957.38 1294.69 1240.31 1604.81 2023.83 1404.9
Replicate 3 Call P P P P P P
Mean 1009.98 1199.81 1025.15 1574.05 1772.29 1329.63
Standard Deviation 46.67 152.76 188.47 26.76 220.08 156.87
Log2 Mean 9.98 10.22 9.99 10.62 10.78 10.37
Log2 Standard Deviation 0.07 0.19 0.26 0.02 0.17 0.18