GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description preproenkephalin
Synonyms Penk; PPA; Penk1; ENK
Chromosome 4
Genetic Map Distance 2.31 cM
RefSeq Accessions NP_001002927; XM_131313
NCBI Entrez Gene 18619 at chr4:4060683-4065592 (mm9) / chr4:4133530-4138965 (mm10)
Ensembl Gene ENSMUSG00000045573
VEGA Gene OTTMUSG00000004406
MGI Gene MGI:104629
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
P22005 Proenkephalin-A 268 0
B1AZQ0 Preproenkephalin 1 (Fragment) 178 0
Q3UXY8 Putative uncharacterized protein (Fragment) 222 0
Q62256 Spermatogenic-specific proenkephalin 18 0
Pfam Domains Opiods_neuropep; Pfam-B_253; Op_neuropeptide; Op_neuropeptide; Pfam-B_253; Op_neuropeptide
Mouse alleles (4)
Allele Name Allele Type
Penktm1(NCOM)Mfgc NorCOMM-projects
Penktm1(KOMP)Mbp KOMP-CSD-Project
Penktm1Dwp Targeted (knock-out)
Penktm1Jep Targeted (knock-out)
Human Homolog PENK (proenkephalin)
Human synonyms
Human cytoband 8q23-q24
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (1)
ENSGALG00000015419 (PENK) encoding ENSGALP00000024825
Gene Ontology
Biological Process (5) neuropeptide signaling pathway; neuropeptide signaling pathway; behavior; behavioral fear response; sensory perception of pain
Cellular Component (1) extracellular region
Molecular Function (1) opioid peptide activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
8
102
6
15
0
0
Cochlea GFP+ cells
6
28
8
6
1
NA
Utricle GFP- cells
356
195
250
116
3
78
Cochlea GFP- cells
358
264
31
17
5
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
152
GFP+
16
0.11
0.00502
Utricle
94
Cochlea
72
0.77
0.515
Embryonic
165
Postnatal
38
0.23
0.0048
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17423030 11.33 ± 1.02 13.70 ± 1.28 [12.72] 1.21 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
0
0
4
No bFGF
0
0
0
0
EGF
0
0
1
0
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
4
No bFGF
0
0.00
0.0114
bFGF
4
EGF
0
0.18
0.0173
No bFGF
0
EGF
0
0.00
0.283
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1427038_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 259.82 139.07 56.47 841.2 564.53 621.78
Replicate 1 Call P P A P P P
Replicate 2 238.45 94.56 86.46 4323.42 232.4 458.15
Replicate 2 Call A A A P P P
Replicate 3 280.48 114.7 33.44 50.15 405.92 185.91
Replicate 3 Call A A A A P M
Replicate 4 516.82 105.85 1027.29 206.86
Replicate 4 Call A A P A
Mean 259.58 116.11 173.3 1330.16 557.54 368.18
Standard Deviation 21.02 22.29 230.04 2027.81 341.28 209.49
Log2 Mean 8.02 6.84 6.58 8.54 8.92 8.34
Log2 Standard Deviation 0.12 0.28 1.71 2.92 0.9 0.86
 
Vestibular ganglion
Replicate 1 891.55 838.27 3446.71 3384.03 2090.19 1229.13
Replicate 1 Call P P P P P P
Replicate 2 841.84 921.99 3130.29 3866.36 3250.01 1195.03
Replicate 2 Call P P P P P P
Replicate 3 805.39 719.18 2094.84 2485.69 2997.12 2016.51
Replicate 3 Call P P P P P P
Mean 846.26 826.48 2890.61 3245.36 2779.11 1480.22
Standard Deviation 43.25 101.92 707.09 700.7 609.87 464.75
Log2 Mean 9.72 9.68 11.47 11.64 11.42 10.49
Log2 Standard Deviation 0.07 0.18 0.38 0.33 0.34 0.42