SHIELD | Shared Harvard Inner-Ear Laboratory Database

MOUSE GENE INFORMATION [PubMed]

Description

otogelin

Synonyms

Otgn

Chromosome

Genetic Map Distance

29.66 cM

RefSeq Accessions

NM_013624; NP_038652

NCBI Entrez Gene

18419 at chr7:53496357-53566804 (mm9) / chr7:46240987-46311434 (mm10)

Ensembl Gene

ENSMUSG00000009487

VEGA Gene

MGI Gene

MGI:1202064

Mouse Protein (1)

UniProt ID	Description	Length (AA)	Predicted # TMs
O55225	Otogelin	2910	0

Pfam Domains

VWD; C8; TIL; VWD; C8; TIL; TIL; VWD; C8; AbfB; TIL; VWD; C8; TIL

Mouse alleles (12)

Allele Name	Allele Type
Otog^{tm1a(KOMP)Mbp}	KOMP-CSD-Project
Otog^{tm1e(KOMP)Mbp}	KOMP-CSD-Project
Otog^{tm2e(KOMP)Mbp}	KOMP-CSD-Project
Otog^{tm2a(KOMP)Mbp}	KOMP-CSD-Project
Otog^{tm1e(KOMP)Wtsi}	KOMP-CSD-Project
Otog^{tm1a(KOMP)Wtsi}	KOMP-CSD-Project
Otog^tm1Prs	Targeted (Reporter)
Otog^twt-2J	Spontaneous
Otog^twt-3J	Spontaneous
Otog^twt-4J	Spontaneous
Otog^twt-5J	Spontaneous
Otog^twt	Spontaneous

Human Homolog

OTOG (otogelin)

Human synonyms

mlemp; OTGN

Human cytoband

11p15.1

Known deafness gene

DFNB18B

Within mapped deafness loci

Associated Human Disease in OMIM

None

Chicken homolog (3)

ENSGALG00000006208 (OTOG) encoding ENSGALP00000010009

ENSGALG00000006208 (OTOG) encoding ENSGALP00000038692

ENSGALG00000006208 (OTOG) encoding ENSGALP00000038693

Gene Ontology

Biological Process (5)	cell adhesion; blood coagulation; L-arabinose metabolic process; adult locomotory behavior; sensory perception of sound
Cellular Component (5)	proteinaceous extracellular matrix; cytosol; extracellular region; membrane; plasma membrane
Molecular Function (2)	alpha-N-arabinofuranosidase activity; structural molecule activity

FACS-Sorted Hair Cells

Data | Chart

	E16a	E16b	P0	P4	P7	P16
Utricle GFP+ cells	294	261	223	360	1435	464
Cochlea GFP+ cells	109	161	67	430	501	NA
Utricle GFP- cells	65	121	217	366	575	141
Cochlea GFP- cells	83	29	10	99	91	NA

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
GFP-	163	GFP+	391	2.39	0.226
Utricle	377	Cochlea	158	0.42	0.65
Embryonic	141	Postnatal	356	2.53	0.311

Adult Cochlear Inner and Outer Hair Cells

Probeset ID	IHC (mean ± sd)	OHC (mean ± sd) [OHC replicate]	Fold Change (OHC/IHC)	False Discovery Rate (FDR)
17478116	91.90 ± 0.45	84.69 ± 5.61 [91.58]	0.92	0.507

Otic Progenitor Cells

Data

Growth Factor	Replicate 1	Replicate 2	Replicate 3	Mean
bFGF	15	13	15	12
No bFGF	24	18	38	22
EGF	5	11	13	10

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
bFGF	12	No bFGF	22	1.84	1
bFGF	12	EGF	10	0.81	0.579
No bFGF	22	EGF	10	0.44	0.00942

Chicken Stereocilium Proteomics

Protein ID	ENSGALP00000010009
Symbol	OTOG
Description	Otogelin
log10 riBAQ in stereocilia (mean ± sd)	-4.70 ± 0.23
log10 riBAQ in utricle (mean ± sd)	-3.55 ± 0.07
Molecules per stereocilium (mean ± error with slope error)	29.26 ± 1.67
Corrected Molecules per stereocilium (mean ± sd)	-55.77 ± 106.01
Stereocilium / Utricle ratio (mean ± sd)	0.07 ± 0.00
Enriched in the stereocilia (FDR < 0.05)	FALSE

Auditory and Vestibular Ganglion Neurons

Probe set ID: 1420797_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	350.86	284.41	294.93	944.71	264.46	221.24
Replicate 1 Call	A	A	A	A	A	A
Replicate 2	383.34	255.62	357.23	491.89	345.73	249.29
Replicate 2 Call	A	A	A	A	A	A
Replicate 3	395.33	225.26	422.58	841.52	292.33	270.82
Replicate 3 Call	A	A	A	A	A	A
Replicate 4			536.79	377.39	262.79	259.35
Replicate 4 Call			A	A	A	A
Mean	376.51	255.1	402.88	663.88	291.33	250.18
Standard Deviation	23.01	29.58	103.37	272.08	38.72	21.2
Log2 Mean	8.55	7.99	8.62	9.28	8.18	7.96
Log2 Standard Deviation	0.09	0.17	0.37	0.63	0.18	0.13

Vestibular ganglion
Replicate 1	587.6	259.13	175.46	238.48	1117.47	3148.09
Replicate 1 Call	A	A	A	A	A	A
Replicate 2	608.87	227.43	168.43	684.2	4312.41	284.85
Replicate 2 Call	A	A	A	A	P	A
Replicate 3	573.83	259.17	166.45	201.09	2838.77	178.32
Replicate 3 Call	A	A	A	A	A	A
Mean	590.1	248.58	170.11	374.59	2756.22	1203.75
Standard Deviation	17.65	18.31	4.74	268.78	1599.07	1684.69
Log2 Mean	9.2	7.95	7.41	8.32	11.22	9.08
Log2 Standard Deviation	0.04	0.11	0.04	0.96	1	2.22

GENE VIEW

Otog