SHIELD | Shared Harvard Inner-Ear Laboratory Database

MOUSE GENE INFORMATION [PubMed]

Description

oxysterol binding protein-like 2

Synonyms

ORP-2; C130070J12Rik

Chromosome

Genetic Map Distance

102.64 cM

RefSeq Accessions

NM_144500; NP_653083

NCBI Entrez Gene

228983 at chr2:179854071-179897385 (mm9) / chr2:180119366-180162680 (mm10)

Ensembl Gene

ENSMUSG00000039050

VEGA Gene

OTTMUSG00000016257

MGI Gene

MGI:2442832

Mouse Protein (4)

UniProt ID	Description	Length (AA)
Q8BX94	Oxysterol-binding protein-related protein 2	484
A2ABW5	Oxysterol binding protein-like 2	484
Q3TDA1	Putative uncharacterized protein	484
Q571D2	MKIAA0772 protein (Fragment)	324

Pfam Domains

Oxysterol_BP

Mouse alleles (2)

Allele Name	Allele Type
Osbpl2^{tm1a(EUCOMM)Wtsi}	EUCOMM-projects
Osbpl2^{tm1e(EUCOMM)Wtsi}	EUCOMM-projects

Human Homolog

OSBPL2 (oxysterol binding protein-like 2)

Human synonyms

ORP-2; ORP2

Human cytoband

20q13.3

Known deafness gene

DFNA67

Within mapped deafness loci

DFNB65

Associated Human Disease in OMIM

None

Chicken homolog (1)

ENSGALG00000005195 (Q5ZLC4_CHICK) encoding ENSGALP00000008330

Gene Ontology

Biological Process (3)	transport; lipid transport; biological_process
Cellular Component (1)	cellular_component
Molecular Function (2)	molecular_function; lipid binding

FACS-Sorted Hair Cells

Data | Chart

	E16a	E16b	P0	P4	P7	P16
Utricle GFP+ cells	73	51	45	74	73	84
Cochlea GFP+ cells	117	66	97	146	119	NA
Utricle GFP- cells	101	59	61	84	171	0
Cochlea GFP- cells	73	62	77	125	102	NA

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
GFP-	83	GFP+	86	1.03	1
Utricle	73	Cochlea	98	1.35	1
Embryonic	75	Postnatal	90	1.19	1

Adult Cochlear Inner and Outer Hair Cells

Probeset ID	IHC (mean ± sd)	OHC (mean ± sd) [OHC replicate]	Fold Change (OHC/IHC)	False Discovery Rate (FDR)
17380711	48.85 ± 11.83	32.00 ± 2.17 [34.54]	0.66	0.501

Otic Progenitor Cells

Data

Growth Factor	Replicate 1	Replicate 2	Replicate 3	Mean
bFGF	626	659	588	673
No bFGF	720	684	645	687
EGF	853	834	839	842

Analysis

Condition A	Mean A	Condition B	Mean B	Fold Change (B/A)	False Discovery Rate (FDR)
bFGF	673	No bFGF	687	1.02	1
bFGF	673	EGF	842	1.25	0.0816
No bFGF	687	EGF	842	1.22	0.119

Chicken Stereocilium Proteomics

The chicken protein was not reproducibly detected in the chicken stereocilia.

The chicken protein was not reproducibly detected in the chicken stereocilia.

Auditory and Vestibular Ganglion Neurons

Probe set ID: 1451974_at

Age	E12	E13	E16	P0	P6	P15
Spiral ganglion
Replicate 1	2306.59	2080.26	2648.71	2255	3048.17	2307.59
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	2332.23	2380.36	2526.2	2521.87	3566.34	1966.68
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	2475.89	2269.55	2700.22	2522.58	3084.08	2926.09
Replicate 3 Call	P	P	P	P	P	P
Replicate 4			2101.69	2768.55	3047.4	2664.37
Replicate 4 Call			P	P	P	P
Mean	2371.57	2243.39	2494.21	2517	3186.5	2466.18
Standard Deviation	91.25	151.75	271.67	209.74	253.81	418.51
Log2 Mean	11.21	11.13	11.28	11.29	11.63	11.25
Log2 Standard Deviation	0.05	0.1	0.17	0.12	0.11	0.25

Vestibular ganglion
Replicate 1	2380.41	2817.07	2610.65	2498.52	2928.11	2917.51
Replicate 1 Call	P	P	P	P	P	P
Replicate 2	2324.11	2621.36	2585.63	2099.84	2812.66	2848.62
Replicate 2 Call	P	P	P	P	P	P
Replicate 3	2197.15	2708.44	2384.56	2410.35	2814.2	2958.21
Replicate 3 Call	P	P	P	P	P	P
Mean	2300.56	2715.62	2526.95	2336.24	2851.66	2908.11
Standard Deviation	93.87	98.05	123.94	209.42	66.22	55.4
Log2 Mean	11.17	11.41	11.3	11.19	11.48	11.51
Log2 Standard Deviation	0.06	0.05	0.07	0.13	0.03	0.03

GENE VIEW

Osbpl2