MOUSE GENE INFORMATION [PubMed]
| Description | oncomodulin | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Synonyms | |||||||||||||||||
| Chromosome | 5 | ||||||||||||||||
| Genetic Map Distance | 82.85 cM | ||||||||||||||||
| RefSeq Accessions | NM_033039; NP_149028 | ||||||||||||||||
| NCBI Entrez Gene | 18261 at chr5:144780676-144811478 (mm9) / chr5:144019797-144050609 (mm10) | ||||||||||||||||
| Ensembl Gene | ENSMUSG00000029618 | ||||||||||||||||
| VEGA Gene | OTTMUSG00000025488 | ||||||||||||||||
| MGI Gene | MGI:97401 | ||||||||||||||||
| Mouse Protein (3) |
|
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| Pfam Domains | Pfam-B_2987; Peptidase_M9_N; Anthrax-tox_M; efhand; efhand | ||||||||||||||||
| Mouse alleles (4) |
|
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| Human Homolog | OCM2 (oncomodulin 2) | ||||||||||||||||
| Human synonyms | OCM | ||||||||||||||||
| Human cytoband | 7q21.2 | ||||||||||||||||
| Known deafness gene | No | ||||||||||||||||
| Within mapped deafness loci | No | ||||||||||||||||
| Associated Human Disease in OMIM |
None
|
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| Chicken homolog (1) |
ENSGALG00000003462 (PRVU_CHICK) encoding ENSGALP00000005475
|
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Gene Ontology
|
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FACS-Sorted Hair Cells
Data |
Chart
E16a |
E16b |
P0 |
P4 |
P7 |
P16 |
|
|---|---|---|---|---|---|---|
Utricle GFP+ cells |
8 |
756 |
4157 |
23549 |
26318 |
3484 |
Cochlea GFP+ cells |
4 |
6 |
152 |
40326 |
390162 |
NA |
Utricle GFP- cells |
0 |
76 |
0 |
51 |
214 |
15 |
Cochlea GFP- cells |
0 |
0 |
23 |
12 |
161 |
NA |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
GFP- |
50 |
GFP+ |
44447 |
881.47 |
4.81e-14 |
Utricle |
4886 |
Cochlea |
43084 |
8.82 |
0.163 |
Embryonic |
106 |
Postnatal |
34902 |
327.37 |
2.54e-61 |
Adult Cochlear Inner and Outer Hair Cells
| Probeset ID | IHC (mean ± sd) | OHC (mean ± sd) [OHC replicate] | Fold Change (OHC/IHC) | False Discovery Rate (FDR) |
|---|---|---|---|---|
| 17454936 | 865.63 ± 63.36 | 4179.63 ± 224.00 [4414.21] | 4.83 | 0.0345 |
Otic Progenitor Cells
Data
Growth Factor |
Replicate 1 |
Replicate 2 |
Replicate 3 |
Mean |
|---|---|---|---|---|
bFGF |
0 |
0 |
1 |
0 |
No bFGF |
0 |
3 |
2 |
1 |
EGF |
2 |
0 |
0 |
1 |
Analysis
Condition A |
Mean A |
Condition B |
Mean B |
Fold Change (B/A) |
False Discovery Rate (FDR) |
|---|---|---|---|---|---|
bFGF |
0 |
No bFGF |
1 |
4.93 |
1 |
bFGF |
0 |
EGF |
1 |
4.45 |
0.394 |
No bFGF |
1 |
EGF |
1 |
0.90 |
1 |
Chicken Stereocilium Proteomics
| Protein ID | ENSGALP00000005475 |
|---|---|
| Symbol | OCM |
| Description | Parvalbumin, thymic CPV3 (oncomodulin) |
| log10 riBAQ in stereocilia (mean ± sd) | -1.37 ± 0.08 |
| log10 riBAQ in utricle (mean ± sd) | -2.27 ± 0.11 |
| Molecules per stereocilium (mean ± error with slope error) | 62810.64 ± 4119.80 |
| Corrected Molecules per stereocilium (mean ± sd) | 63019.59 ± 6119.16 |
| Stereocilium / Utricle ratio (mean ± sd) | 7.86 ± 0.68 |
| Enriched in the stereocilia (FDR < 0.05) | TRUE |
Auditory and Vestibular Ganglion Neurons
No probes available for Ocm on Affymetrix MOE430_2.0 GeneChip.