GENE VIEW

Nf2

MOUSE GENE INFORMATION [PubMed]
Description neurofibromatosis 2
Synonyms moesin-ezrin-radixin-like protein; schwannomin; merlin
Chromosome 11
Genetic Map Distance 3.00 cM
RefSeq Accessions NM_001252250; NM_001252251; NM_001252252; NM_001252253; NM_010898; NP_001239179; NP_001239180; NP_001239181; NP_001239182; NP_035028
NCBI Entrez Gene 18016 at chr11:4665851-4749530 (mm9) / chr11:4757632-4849544 (mm10)
Ensembl Gene ENSMUSG00000009073
VEGA Gene OTTMUSG00000005071
MGI Gene MGI:97307
Mouse Protein (9)
UniProt ID Description Length (AA) Predicted # TMs
P46662 Merlin 596 0
Q3TIW4 Putative uncharacterized protein 418 0
Q5NCK3 Neurofibromatosis 2 591 0
Q5NCK4 Neurofibromatosis 2 596 0
Q5NCK5 Neurofibromatosis 2 (Fragment) 207 0
Q5NCK6 Neurofibromatosis 2 546 0
Q62207 Schwannomin (Fragment) 11 0
Q99K59 Nf2 protein 353 0
Q9D3K3 Putative uncharacterized protein 546 0
Pfam Domains FERM_N; FERM_M; FERM_C; ERM
Mouse alleles (6)
Allele Name Allele Type
Nf2tm1e(KOMP)Wtsi KOMP-CSD-Project
Nf2tm1a(KOMP)Wtsi KOMP-CSD-Project
Nf2tm1Gth Targeted (Reporter)
Nf2tm1Tyj Targeted (knock-out)
Nf2tm2.1Gth Targeted (knock-out)
Nf2tm2Gth Targeted (Floxed/Frt)
Human Homolog NF2 (neurofibromin 2 (merlin))
Human synonyms ACN; BANF; SCH
Human cytoband 22q12.2
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (3)
ENSGALG00000008073 (Q5ZJB0_CHICK) encoding ENSGALP00000013091
ENSGALG00000008073 (Q5ZJB0_CHICK) encoding ENSGALP00000032938
ENSGALG00000008073 (Q5ZJB0_CHICK) encoding ENSGALP00000034386
Gene Ontology
Biological Process (22) regulation of hippo signaling cascade; regulation of cell proliferation; negative regulation of protein kinase activity; negative regulation of protein kinase activity; cell-cell junction organization; negative regulation of DNA replication; actin cytoskeleton organization; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of JAK-STAT cascade; negative regulation of cell growth; ectoderm development; mesoderm formation; negative regulation of cell proliferation; odontogenesis of dentin-containing tooth; negative regulation of cell proliferation; negative regulation of cell proliferation; Schwann cell proliferation; negative regulation of cell-cell adhesion; positive regulation of stress fiber assembly; negative regulation of MAPKKK cascade; lens fiber cell differentiation
Cellular Component (27) cytoplasm; cytoplasm; cytoplasm; cytoplasm; soluble fraction; insoluble fraction; nucleus; nucleus; adherens junction; membrane raft; synapse; ruffle; cytoskeleton; membrane; extrinsic to membrane; cell projection; nucleolus; perinuclear region of cytoplasm; early endosome; perinuclear region of cytoplasm; plasma membrane; plasma membrane; protein complex; cortical actin cytoskeleton; filopodium; cleavage furrow; lamellipodium
Molecular Function (8) protein binding; beta-catenin binding; protein domain specific binding; binding; cytoskeletal protein binding; integrin binding; protein binding; protein binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
78
40
65
392
244
993
Cochlea GFP+ cells
110
57
121
1413
1975
NA
Utricle GFP- cells
96
28
32
82
69
62
Cochlea GFP- cells
75
51
14
73
78
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
60
GFP+
499
8.24
0.00174
Utricle
182
Cochlea
397
2.18
0.976
Embryonic
67
Postnatal
401
5.96
0.0813
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17260036 45.05 ± 4.56 68.18 ± 7.52 [56.78] 1.51 0.339
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
3372
3368
3362
3210
No bFGF
2727
2884
2697
2980
EGF
4029
3840
3756
3875
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
3210
No bFGF
2980
0.93
1
bFGF
3210
EGF
3875
1.21
0.0892
No bFGF
2980
EGF
3875
1.30
0.0143
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000013091
Symbol NF2
Description Neurofibromin 2 (merlin)
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -5.72 ± ND
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1421820_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 796.64 803.74 1226.24 1210.4 608.81 563.98
Replicate 1 Call P P P P P P
Replicate 2 878.6 827.11 1309.85 819.62 1014.68 214.91
Replicate 2 Call P P P P P A
Replicate 3 958.26 866.12 1382.3 1363.9 661.08 504.7
Replicate 3 Call P P P P P P
Replicate 4 1024.76 1115.36 952.43 401.11
Replicate 4 Call P P P P
Mean 877.83 832.32 1235.79 1127.32 809.25 421.18
Standard Deviation 80.81 31.52 154.46 229.27 203.99 153.1
Log2 Mean 9.77 9.7 10.26 10.11 9.63 8.63
Log2 Standard Deviation 0.13 0.05 0.19 0.31 0.37 0.62
 
Vestibular ganglion
Replicate 1 949.22 1060.06 479.91 345.74 278.26 450.57
Replicate 1 Call P P P P M P
Replicate 2 892.21 974.73 560.27 358.94 414.82 435.16
Replicate 2 Call P P P P P P
Replicate 3 942.14 971.86 341.41 578.51 515.29 418.86
Replicate 3 Call P P A P P P
Mean 927.86 1002.22 460.53 427.73 402.79 434.86
Standard Deviation 31.07 50.11 110.71 130.75 118.97 15.86
Log2 Mean 9.86 9.97 8.82 8.7 8.61 8.76
Log2 Standard Deviation 0.05 0.07 0.37 0.41 0.45 0.05
Probe set ID: 1427708_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 39.5 26.74 33.48 29.03 47.34 17.34
Replicate 1 Call A A A A A A
Replicate 2 42.16 17.96 49.01 29.64 24.61 28.48
Replicate 2 Call P A P A A A
Replicate 3 41.88 29.93 41.35 29.74 32.23 14.77
Replicate 3 Call A A P A A A
Replicate 4 28.86 25.63 26.9 17.55
Replicate 4 Call A A A A
Mean 41.18 24.88 38.18 28.51 32.77 19.54
Standard Deviation 1.46 6.2 8.87 1.95 10.22 6.1
Log2 Mean 5.36 4.6 5.23 4.83 4.99 4.24
Log2 Standard Deviation 0.05 0.39 0.34 0.1 0.42 0.41
 
Vestibular ganglion
Replicate 1 26.38 24.85 15.74 14.65 29.93 36.5
Replicate 1 Call A A A A A A
Replicate 2 40.49 21.84 22.09 31.44 16.11 81.59
Replicate 2 Call A A A A A P
Replicate 3 38.84 28.8 28.2 23.37 20.62 62.12
Replicate 3 Call A P A A A A
Mean 35.24 25.16 22.01 23.15 22.22 60.07
Standard Deviation 7.71 3.49 6.23 8.4 7.05 22.61
Log2 Mean 5.11 4.64 4.42 4.46 4.43 5.83
Log2 Standard Deviation 0.34 0.2 0.42 0.56 0.45 0.59
Probe set ID: 1450382_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 117.35 78.64 88.33 108.29 96.36 116.85
Replicate 1 Call A A A A A A
Replicate 2 132.97 58.21 74.66 78.53 113.4 139.57
Replicate 2 Call A A A A A A
Replicate 3 145.44 84.53 72.77 80.69 71.23 97.57
Replicate 3 Call A P A A A A
Replicate 4 86.33 87.74 94.27 163.26
Replicate 4 Call A A A A
Mean 131.92 73.79 80.52 88.81 93.82 129.31
Standard Deviation 14.07 13.81 7.94 13.57 17.32 28.41
Log2 Mean 7.04 6.19 6.33 6.46 6.53 6.99
Log2 Standard Deviation 0.16 0.29 0.14 0.21 0.28 0.32
 
Vestibular ganglion
Replicate 1 121.37 76.42 54.27 58.77 71.95 87.19
Replicate 1 Call A A A A A A
Replicate 2 125.37 84.37 65.09 49.94 48.16 82.45
Replicate 2 Call A A A A A A
Replicate 3 166.51 74.62 51.48 74.58 109.87 67.95
Replicate 3 Call A A A A A A
Mean 137.75 78.47 56.95 61.1 76.66 79.2
Standard Deviation 24.99 5.19 7.19 12.48 31.12 10.02
Log2 Mean 7.09 6.29 5.82 5.91 6.18 6.3
Log2 Standard Deviation 0.25 0.09 0.18 0.29 0.6 0.19
Probe set ID: 1451829_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1419.8 1324.9 1634.47 1930.27 2924.78 3304.18
Replicate 1 Call P A P P A P
Replicate 2 1438.08 1524.36 1930.58 2832.64 2617.64 3578.82
Replicate 2 Call P P P P M P
Replicate 3 1367.01 1350 1781.67 1702.16 2831.43 2682.12
Replicate 3 Call P P P P A P
Replicate 4 2273.03 1680.43 3371.89 2852.1
Replicate 4 Call P P P P
Mean 1408.3 1399.75 1904.94 2036.38 2936.44 3104.31
Standard Deviation 36.91 108.64 273.56 542.74 317.5 411.08
Log2 Mean 10.46 10.45 10.88 10.96 11.51 11.59
Log2 Standard Deviation 0.04 0.11 0.2 0.35 0.15 0.19
 
Vestibular ganglion
Replicate 1 1488.36 1745.21 1866.66 1495.86 1964.47 1784.36
Replicate 1 Call P P P A A P
Replicate 2 1382.33 1683.7 1732.4 2125.26 1859.63 1764.06
Replicate 2 Call P P P A A P
Replicate 3 1484.55 1624.7 1500.28 1670.98 1931.78 1863.26
Replicate 3 Call P P A P A P
Mean 1451.75 1684.54 1699.78 1764.03 1918.63 1803.89
Standard Deviation 60.15 60.26 185.36 324.85 53.64 52.41
Log2 Mean 10.5 10.72 10.73 10.77 10.91 10.82
Log2 Standard Deviation 0.06 0.05 0.16 0.26 0.04 0.04