GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description neurogenic differentiation 1
Synonyms Neurod; bHLHa3; BETA2
Chromosome 2
Genetic Map Distance 47.58 cM
RefSeq Accessions NM_010894; NP_035024
NCBI Entrez Gene 18012 at chr2:79292798-79296793 (mm9) / chr2:79452641-79456636 (mm10)
Ensembl Gene ENSMUSG00000034701
VEGA Gene OTTMUSG00000013310
MGI Gene MGI:1339708
Mouse Protein (5)
UniProt ID Description Length (AA) Predicted # TMs
Q60867 Neurogenic differentiation factor 1 357 0
B1AYM8 Neurogenic differentiation 1 357 0
P70449 NeuroD5 (Fragment) 24 0
Q505D0 Neurod1 protein 211 0
Q8CEI7 Putative uncharacterized protein 357 0
Pfam Domains Daxx; Nop53; DUF2146; DUF2890; HLH; Neuro_bHLH
Mouse alleles (4)
Allele Name Allele Type
Neurod1tm1.1Kan Targeted (Floxed/Frt)
Neurod1tm1Jle Targeted (Reporter)
Neurod1tm1Kan Targeted (Floxed/Frt)
Neurod1tm1Mjts Targeted (knock-out)
Human Homolog NEUROD1 (neurogenic differentiation 1)
Human synonyms BETA2; BHF-1; bHLHa3; MODY6; NEUROD
Human cytoband 2q32
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000008908 (NDF1_CHICK) encoding ENSGALP00000014468
Gene Ontology
Biological Process (48) positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; pancreatic A cell fate commitment; negative regulation of JAK-STAT cascade; pancreatic PP cell fate commitment; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of sequence-specific DNA binding transcription factor activity; dentate gyrus development; dentate gyrus development; dentate gyrus development; positive regulation of transcription; DNA-dependent; positive regulation of transcription; DNA-dependent; glucose homeostasis; regulation of transcription; DNA-dependent; cell differentiation; multicellular organismal development; positive regulation of apoptotic process; positive regulation of cell differentiation; positive regulation of cell differentiation; positive regulation of neuron differentiation; positive regulation of neuron differentiation; nitric oxide mediated signal transduction; signal transduction involved in regulation of gene expression; negative regulation of apoptotic process; inner ear development; response to glucose stimulus; endocrine pancreas development; insulin secretion; endocrine pancreas development; nervous system development; amacrine cell differentiation; transcription; DNA-dependent; enteroendocrine cell differentiation; cell fate commitment; regulation of cell cycle arrest; positive regulation of transcription from RNA polymerase II promoter; embryonic organ morphogenesis; anterior/posterior pattern specification; regulation of intestinal epithelial structure maintenance; camera-type eye development; cerebellum development; nucleocytoplasmic transport; positive regulation of transcription regulatory region DNA binding; cellular response to glucose stimulus; hindbrain development; positive regulation of transcription from RNA polymerase II promoter
Cellular Component (9) intracellular part; intracellular part; cytoplasm; cytoplasm; nucleus; nucleus; nucleus; nucleus; nucleus
Molecular Function (16) sequence-specific DNA binding; sequence-specific DNA binding; E-box binding; E-box binding; transcription coactivator activity; protein binding; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding; transcription factor binding; chromatin binding; RNA polymerase II activating transcription factor binding; double-stranded DNA binding; RNA polymerase II transcription coactivator activity; protein heterodimerization activity; protein heterodimerization activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
2862
943
3
4
193
6
Cochlea GFP+ cells
20726
51
13
1
18
NA
Utricle GFP- cells
50
215
4
0
0
0
Cochlea GFP- cells
11
27
4
9
0
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
29
GFP+
2256
76.61
1.51e-14
Utricle
357
Cochlea
2086
5.84
0.0278
Embryonic
3111
Postnatal
18
0.01
5.97e-12
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17387267 9.39 ± 0.44 11.05 ± 0.87 [10.00] 1.18 0.501
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
27
8
7
12
No bFGF
33
16
10
15
EGF
2399
2007
2268
2225
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
12
No bFGF
15
1.25
1
bFGF
12
EGF
2225
178.42
3.7e-80
No bFGF
15
EGF
2225
142.31
1.53e-107
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1426412_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 8556.91 6077.91 1073.66 642.64 263.54 63.22
Replicate 1 Call P P P P P P
Replicate 2 8570.64 6498.24 1628.28 442.9 353.08 89.4
Replicate 2 Call P P P P P P
Replicate 3 8662.02 6684.79 625.1 737.62 25.93 196.06
Replicate 3 Call P P P P A P
Replicate 4 925.81 826.46 35.41 220.73
Replicate 4 Call P P A P
Mean 8596.52 6420.31 1063.21 662.41 169.49 142.35
Standard Deviation 57.14 310.85 420.41 164.46 164.46 77.66
Log2 Mean 13.07 12.65 9.97 9.33 6.59 6.97
Log2 Standard Deviation 0.01 0.07 0.57 0.39 1.94 0.87
 
Vestibular ganglion
Replicate 1 4930.99 1588.17 939.84 3982.12 462.54 616.47
Replicate 1 Call P P P P P P
Replicate 2 4827.96 1886.56 1351.76 728.26 921.79 305.03
Replicate 2 Call P P P P P P
Replicate 3 4557.65 1473.66 3488.71 3825.67 3779.28 215.82
Replicate 3 Call P P P P P P
Mean 4772.2 1649.46 1926.77 2845.35 1721.2 379.11
Standard Deviation 192.81 213.16 1368.27 1835.12 1797.08 210.35
Log2 Mean 12.22 10.68 10.68 11.12 10.2 8.42
Log2 Standard Deviation 0.06 0.18 0.98 1.4 1.54 0.77
Probe set ID: 1426413_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 8889.66 5437.3 845.69 837.11 419.62 135.36
Replicate 1 Call P P P P P P
Replicate 2 8947.24 6451.75 1914.12 556.22 362.45 110.34
Replicate 2 Call P P P P P A
Replicate 3 9013.96 6738.15 642.15 911.73 98.97 193.6
Replicate 3 Call P P P P A P
Replicate 4 997.98 935.21 96.8 345.56
Replicate 4 Call P P A P
Mean 8950.29 6209.07 1099.99 810.07 244.46 196.22
Standard Deviation 62.21 683.54 561.99 174.32 170.85 105.5
Log2 Mean 13.13 12.59 9.98 9.63 7.61 7.47
Log2 Standard Deviation 0.01 0.16 0.67 0.35 1.15 0.72
 
Vestibular ganglion
Replicate 1 5309.17 1392.05 762.61 3259.81 393.24 567.2
Replicate 1 Call P P P P P P
Replicate 2 5207.16 1492.33 1165.46 774.99 712.77 216.57
Replicate 2 Call P P P P P P
Replicate 3 5478.44 1244.78 3166.7 4082.48 3518.5 172.72
Replicate 3 Call P P P P P P
Mean 5331.59 1376.39 1698.26 2705.76 1541.5 318.83
Standard Deviation 137.02 124.52 1287.56 1721.95 1719.57 216.21
Log2 Mean 12.38 10.42 10.46 11.09 9.96 8.11
Log2 Standard Deviation 0.04 0.13 1.05 1.3 1.63 0.91