GENE VIEW

Nog

MOUSE GENE INFORMATION [PubMed]
Description noggin
Synonyms
Chromosome 11
Genetic Map Distance 54.34 cM
RefSeq Accessions NM_008711; NP_032737
NCBI Entrez Gene 18121 at chr11:89161952-89163873 (mm9) / chr11:89300638-89302559 (mm10)
Ensembl Gene ENSMUSG00000048616
VEGA Gene OTTMUSG00000001321
MGI Gene MGI:104327
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
P97466 Noggin 232 0
A2RTJ4 Noggin 232 0
Pfam Domains Noggin; Pfam-B_8559
Mouse alleles (2)
Allele Name Allele Type
Nogtm1.1Rmh Targeted (Floxed/Frt)
Nogtm1Amc Targeted (Reporter)
Human Homolog NOG (noggin)
Human synonyms SYM1; SYNS1
Human cytoband 17q22
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000003114 (NOGG_CHICK) encoding ENSGALP00000004907
Gene Ontology
Biological Process (69) mesenchymal cell differentiation; positive regulation of epithelial cell proliferation; wound healing; positive regulation of epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; axial mesoderm development; positive regulation of transcription from RNA polymerase II promoter; somite development; positive regulation of transcription from RNA polymerase II promoter; lung morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; negative regulation of BMP signaling pathway; pituitary gland development; negative regulation of BMP signaling pathway; face morphogenesis; negative regulation of BMP signaling pathway; ureteric bud formation; endoderm formation; positive regulation of branching involved in ureteric bud morphogenesis; mesoderm formation; positive regulation of branching involved in ureteric bud morphogenesis; osteoblast differentiation; epithelial to mesenchymal transition; regulation of neuron differentiation; negative regulation of astrocyte differentiation; negative regulation of astrocyte differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of cartilage development; neural tube development; cellular response to BMP stimulus; cell differentiation; multicellular organismal development; cartilage development; pattern specification process; prostatic bud formation; skeletal system development; anatomical structure formation involved in morphogenesis; central nervous system development; notochord morphogenesis; ureteric bud development; anatomical structure formation involved in morphogenesis; BMP signaling pathway; cell differentiation in hindbrain; brain development; somatic stem cell maintenance; dorsal/ventral pattern formation; embryonic digit morphogenesis; negative regulation of cell differentiation; regulation of BMP signaling pathway; embryonic skeletal system development; urogenital system development; limb development; in utero embryonic development; positive regulation of glomerulus development; embryonic skeletal joint morphogenesis; negative regulation of cell migration; negative regulation of cytokine activity; middle ear morphogenesis; fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; negative regulation of osteoblast differentiation; regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; negative regulation of BMP signaling pathway; neural tube closure; negative regulation of BMP signaling pathway; neural plate morphogenesis; axon guidance; spinal cord development; motor axon guidance
Cellular Component (3) extracellular region; extracellular space; extracellular space
Molecular Function (3) protein complex binding; protein homodimerization activity; cytokine binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
47
0
25
4
27
0
Cochlea GFP+ cells
5
55
7
1
49
NA
Utricle GFP- cells
24
30
21
7
2
15
Cochlea GFP- cells
48
15
27
24
120
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
30
GFP+
20
0.66
0.752
Utricle
17
Cochlea
35
2.04
1
Embryonic
28
Postnatal
23
0.84
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17267656 7.49 ± 0.34 8.45 ± 1.54 [11.70] 1.13 0.513
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
1
2
1
No bFGF
0
1
7
2
EGF
0
1
0
1
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1
No bFGF
2
1.59
1
bFGF
1
EGF
1
0.61
0.621
No bFGF
2
EGF
1
0.39
0.228
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1422300_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 44.02 30.74 48.85 19.9 36.55 4.69
Replicate 1 Call A A A A A A
Replicate 2 25.5 33.75 26.14 22.52 29.98 17.14
Replicate 2 Call A A A A A A
Replicate 3 29.84 38.49 11.55 21.61 20.81 28.25
Replicate 3 Call A A A A A A
Replicate 4 30.55 24.88 24.99 20.99
Replicate 4 Call A A A A
Mean 33.12 34.33 29.27 22.23 28.08 17.77
Standard Deviation 9.69 3.91 15.37 2.08 6.78 9.86
Log2 Mean 5.01 5.1 4.7 4.47 4.78 3.89
Log2 Standard Deviation 0.41 0.16 0.87 0.13 0.35 1.14
 
Vestibular ganglion
Replicate 1 28.26 14.68 34.53 44.76 23.13 28.29
Replicate 1 Call A A A A A A
Replicate 2 12.45 21.73 18.56 38.2 19.21 11.91
Replicate 2 Call A A A A A A
Replicate 3 18.54 28.54 30.93 27.97 39.21 31.68
Replicate 3 Call A A A A A A
Mean 19.75 21.65 28.01 36.98 27.18 23.96
Standard Deviation 7.97 6.93 8.38 8.46 10.6 10.57
Log2 Mean 4.22 4.38 4.76 5.18 4.7 4.46
Log2 Standard Deviation 0.59 0.48 0.48 0.35 0.53 0.77