GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description myosin VIIA and Rab interacting protein
Synonyms A230081N12Rik; Slac2-c
Chromosome 9
Genetic Map Distance 71.50 cM
RefSeq Accessions NM_144557; NP_653140
NCBI Entrez Gene 245049 at chr9:120213191-120383952 (mm9) / chr9:120303919-120474841 (mm10)
Ensembl Gene ENSMUSG00000041794
VEGA Gene OTTMUSG00000023760
MGI Gene MGI:2384407
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q8K3I4 Rab effector MyRIP 856 0
A1L320 Myosin VIIA and Rab interacting protein 856 0
A1L321 Myosin VIIA and Rab interacting protein 856 0
Pfam Domains Pfam-B_18383; RPH3A_effect_N; MOBP_C-Myrip
Mouse alleles (1)
Allele Name Allele Type
Myriptm1(KOMP)Vlcg KOMP-Regeneron-Project
Human Homolog MYRIP (myosin VIIA and Rab interacting protein)
Human synonyms SLAC2-C; SLAC2C
Human cytoband 3p22.1
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
None
Chicken homolog (0)
Gene Ontology
Biological Process (2) vesicle transport along actin filament; intracellular protein transport
Cellular Component (7) synapse; cytoplasm; melanosome; photoreceptor outer segment; apical plasma membrane; secretory granule membrane; actin cytoskeleton
Molecular Function (7) myosin binding; Rab GTPase binding; Rab GTPase binding; metal ion binding; protein binding; actin binding; myosin binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
0
0
0
0
6
Cochlea GFP+ cells
0
7
3
1
4
NA
Utricle GFP- cells
9
28
59
33
159
0
Cochlea GFP- cells
2
6
25
68
55
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
40
GFP+
2
0.06
0.0323
Utricle
25
Cochlea
17
0.70
1
Embryonic
7
Postnatal
29
4.02
0.469
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17523201 15.95 ± 1.19 17.38 ± 0.64 [16.95] 1.09 0.553
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
514
542
557
404
No bFGF
598
641
737
545
EGF
226
229
231
229
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
404
No bFGF
545
1.35
1
bFGF
404
EGF
229
0.57
5.52e-6
No bFGF
545
EGF
229
0.42
1.11e-13
Chicken Stereocilium Proteomics
No chicken homolog has been identified for Myrip.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1460601_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 288.13 323.11 662.28 872.78 1498.13 840.68
Replicate 1 Call P P P P P P
Replicate 2 297.96 308.27 597.44 818.76 1834.61 327.65
Replicate 2 Call P P P P P P
Replicate 3 322.79 293.12 664.75 1109.12 989.07 1406.08
Replicate 3 Call P P P P P P
Replicate 4 380.64 1098.93 1307.45 1346.7
Replicate 4 Call P P P P
Mean 302.96 308.17 576.28 974.9 1407.32 980.28
Standard Deviation 17.86 15 134.1 150.78 353.9 503.65
Log2 Mean 8.24 8.27 9.14 9.92 10.42 9.73
Log2 Standard Deviation 0.08 0.07 0.38 0.23 0.37 0.98
 
Vestibular ganglion
Replicate 1 439.19 604.24 803.39 939.05 1272.33 1131.39
Replicate 1 Call P P P P P P
Replicate 2 429.35 628.28 825.61 966.63 1067.22 1227.16
Replicate 2 Call P P P P P P
Replicate 3 456.21 663.32 840.67 971.32 1249.36 1133
Replicate 3 Call P P P P P P
Mean 441.58 631.95 823.22 959 1196.3 1163.85
Standard Deviation 13.59 29.71 18.75 17.44 112.38 54.83
Log2 Mean 8.79 9.3 9.68 9.91 10.22 10.18
Log2 Standard Deviation 0.04 0.07 0.03 0.03 0.14 0.07