GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description MARVEL (membrane-associating) domain containing 2
Synonyms Tricellulin; Tric-a; Tric; Tric-b; Tric-c; Mrvldc2
Chromosome 13
Genetic Map Distance 53.23 cM
RefSeq Accessions NM_001038602; NM_178410; NP_001033691; NP_848497
NCBI Entrez Gene 218518 at chr13:101365912-101386926 (mm9) / chr13:100595957-100616971 (mm10)
Ensembl Gene ENSMUSG00000021636
VEGA Gene
MGI Gene MGI:2446166
Mouse Protein (6)
UniProt ID Description Length (AA) Predicted # TMs
Q3UZP0 MARVEL domain-containing protein 2 555 4
A1BQX3 Tricellulin isoform a 555 4
A1BQX4 Tricellulin isoform b 373 4
A1BQX5 Tricellulin isoform c 326 3
A3KML9 Marveld2 protein 140 0
Q3U162 Putative uncharacterized protein 140 0
Pfam Domains Pfam-B_676; MARVEL; Herpes_gE; Pfam-B_17305; Occludin_ELL
Mouse alleles (2)
Allele Name Allele Type
Marveld2tm1a(EUCOMM)Wtsi EUCOMM-projects
Marveld2tm1e(EUCOMM)Wtsi EUCOMM-projects
Human Homolog MARVELD2 (MARVEL domain containing 2)
Human synonyms DFNB49; MARVD2; MRVLDC2; Tric
Human cytoband 5q13.2
Known deafness gene DFNB49
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000002361 (OCEL1) encoding ENSGALP00000003714
Gene Ontology
Biological Process (2) biological_process; sensory perception of sound
Cellular Component (7) integral to membrane; membrane; membrane; plasma membrane; tight junction; cell junction; cellular_component
Molecular Function (1) molecular_function
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
112
114
57
54
124
71
Cochlea GFP+ cells
93
143
200
202
439
NA
Utricle GFP- cells
41
26
25
37
5
15
Cochlea GFP- cells
46
9
4
11
21
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
22
GFP+
146
6.59
0.00784
Utricle
57
Cochlea
117
2.05
1
Embryonic
73
Postnatal
90
1.24
0.965
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17295685 72.63 ± 2.23 66.20 ± 13.05 [61.14] 0.91 0.698
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
0
2
1
1
No bFGF
2
2
3
3
EGF
1
1
3
2
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
1
No bFGF
3
2.55
1
bFGF
1
EGF
2
1.65
0.802
No bFGF
3
EGF
2
0.65
0.539
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
No probes available for Marveld2 on Affymetrix MOE430_2.0 GeneChip.