GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description mannosidase, beta A, lysosomal
Synonyms Bmn; 2410030O07Rik; B930014J03Rik
Chromosome 3
Genetic Map Distance 62.65 cM
RefSeq Accessions NM_027288; NP_081564
NCBI Entrez Gene 110173 at chr3:135148575-135234368 (mm9) / chr3:135485611-135571404 (mm10)
Ensembl Gene ENSMUSG00000028164
VEGA Gene OTTMUSG00000030307
MGI Gene MGI:88175
Mouse Protein (2)
UniProt ID Description Length (AA) Predicted # TMs
Q8K2I4 Beta-mannosidase 879 0
D6RGR1 Uncharacterized protein 186 0
Pfam Domains Glyco_hydro_2_N; Glyco_hydro_2_C; Pfam-B_67
Mouse alleles (2)
Allele Name Allele Type
Manbatm1a(KOMP)Wtsi KOMP-CSD-Project
Manbatm1Khf Targeted (knock-out)
Human Homolog MANBA (mannosidase, beta A, lysosomal)
Human synonyms MANB1
Human cytoband 4q22-q25
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000012308 (MANBA) encoding ENSGALP00000020088
Gene Ontology
Biological Process (3) carbohydrate metabolic process; metabolic process; glycoprotein catabolic process
Cellular Component (3) soluble fraction; lysosome; lysosome
Molecular Function (8) catalytic activity; hydrolase activity; hydrolase activity; acting on glycosyl bonds; cation binding; hydrolase activity; hydrolyzing O-glycosyl compounds; mannose binding; beta-mannosidase activity; beta-mannosidase activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
125
243
93
410
221
176
Cochlea GFP+ cells
14
109
34
94
31
NA
Utricle GFP- cells
92
229
189
147
208
62
Cochlea GFP- cells
34
50
82
55
207
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
123
GFP+
141
1.14
0.905
Utricle
183
Cochlea
71
0.39
0.998
Embryonic
112
Postnatal
143
1.28
0.99
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17402905 71.45 ± 5.94 41.74 ± 7.88 [36.22] 0.58 0.412
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
8
11
2
6
No bFGF
24
23
28
35
EGF
10
8
7
8
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
6
No bFGF
35
5.16
0.115
bFGF
6
EGF
8
1.28
0.674
No bFGF
35
EGF
8
0.25
1.5e-7
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000020088
Symbol MANBA
Description Mannosidase, beta A, lysosomal
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -5.87 ± 0.45
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1450626_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 268.01 507.72 515.75 822.88 1209.72 1937.19
Replicate 1 Call P P P P P P
Replicate 2 271.62 464.84 470.74 1774.22 1142.41 1716.03
Replicate 2 Call P P P P P P
Replicate 3 282.27 461.71 461.79 485.41 1675.41 1356.4
Replicate 3 Call P P P P P P
Replicate 4 452.59 496.78 1397.03 1492.76
Replicate 4 Call P P P P
Mean 273.97 478.09 475.22 894.82 1356.14 1625.6
Standard Deviation 7.41 25.71 28.02 606.79 238.55 255.2
Log2 Mean 8.1 8.9 8.89 9.59 10.39 10.65
Log2 Standard Deviation 0.04 0.08 0.08 0.88 0.25 0.23
 
Vestibular ganglion
Replicate 1 497.58 708 803.43 1139.33 2036.5 2082.15
Replicate 1 Call P P P P P P
Replicate 2 443.62 721.23 1099.73 794.87 2502 1778.91
Replicate 2 Call P P P P P P
Replicate 3 412.65 713.72 1024.96 662.74 2155.62 2094.84
Replicate 3 Call P P P P P P
Mean 451.28 714.32 976.04 865.65 2231.37 1985.3
Standard Deviation 42.98 6.64 154.09 246.05 241.82 178.85
Log2 Mean 8.81 9.48 9.92 9.72 11.12 10.95
Log2 Standard Deviation 0.14 0.01 0.24 0.4 0.15 0.13