GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description myosin VIIA
Synonyms nmf371; USH1B; Myo7; polka; Hdb
Chromosome 7
Genetic Map Distance 53.57 cM
RefSeq Accessions NM_001256081; NM_001256082; NM_001256083; NM_008663; NP_001243010; NP_001243011; NP_001243012; NP_032689
NCBI Entrez Gene 17921 at chr7:105199570-105268003 (mm9) / chr7:98051054-98119522 (mm10)
Ensembl Gene ENSMUSG00000030761
VEGA Gene OTTMUSG00000017631
MGI Gene MGI:104510
Mouse Protein (4)
UniProt ID Description Length (AA) Predicted # TMs
P97479 Myosin-VIIa 2215 0
D3YUT5 Uncharacterized protein 139 0
Q5MJ56 Myosin VIIa isoform 2 2172 0
Q5MJ57 Myosin VIIa isoform 1 2166 0
Pfam Domains Myosin_head; IQ; IQ; IQ; IQ; Pfam-B_17172; MyTH4; FERM_N; FERM_M; SH3_1; Pfam-B_17172; MyTH4; FERM_N; FERM_M
Mouse alleles (19)
Allele Name Allele Type
Myo7atm1a(EUCOMM)Hmgu EUCOMM-projects
Myo7atm1e(EUCOMM)Hmgu EUCOMM-projects
Myo7atm1a(EUCOMM)Wtsi EUCOMM-projects
Myo7atm1e(EUCOMM)Wtsi EUCOMM-projects
Myo7a26SB Chemically induced (ENU)
Myo7a3336SB Chemically induced (ENU)
Myo7a4494SB Chemically induced (ENU)
Myo7a4626SB Chemically induced (ENU)
Myo7a816SB Chemically induced (ENU)
Myo7aHdb Chemically induced (ENU)
Myo7apolka Chemically induced (ENU)
Myo7ash1-11J Chemically induced (ENU)
Myo7ash1-1R Chemically induced (ENU)
Myo7ash1-6J Spontaneous
Myo7ash1-6R Chemically induced (ENU)
Myo7ash1-7J Chemically induced (ENU)
Myo7ash1-8J Spontaneous
Myo7ash1-9J Spontaneous
Myo7ash1 Spontaneous
Human Homolog MYO7A (myosin VIIA)
Human synonyms DFNA11; DFNB2; MYOVIIA; MYU7A; NSRD2; USH1B
Human cytoband 11q13.5
Known deafness gene DFNA11/DFNB2/USH1B
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000000733 (MYO7A) encoding ENSGALP00000001044
Gene Ontology
Biological Process (55) inner ear development; inner ear development; post-embryonic organ morphogenesis; post-embryonic organ morphogenesis; inner ear development; post-embryonic organ morphogenesis; post-embryonic organ morphogenesis; inner ear development; auditory receptor cell stereocilium organization; inner ear receptor cell differentiation; inner ear receptor cell differentiation; inner ear development; auditory receptor cell stereocilium organization; pigment granule transport; auditory receptor cell stereocilium organization; phagolysosome assembly; pigment granule localization; pigment granule localization; pigment granule localization; sensory perception of light stimulus; sensory perception of light stimulus; metabolic process; phagocytosis; sensory perception; auditory receptor cell differentiation; pigment granule transport; inner ear morphogenesis; inner ear morphogenesis; sensory perception of sound; sensory perception of sound; sensory perception of sound; mechanoreceptor differentiation; sensory perception of sound; sensory perception of sound; cell projection organization; sensory perception of sound; sensory perception of sound; visual perception; visual perception; visual perception; auditory receptor cell differentiation; auditory receptor cell differentiation; inner ear morphogenesis; ATP catabolic process; sensory perception of sound; sensory perception of sound; lysosome organization; sensory perception of sound; actin filament-based movement; sensory perception of sound; actin filament-based movement; sensory perception of sound; equilibrioception; metabolic process; metabolic process
Cellular Component (31) stereocilium; stereocilium; stereocilium; melanosome; synapse; synapse; photoreceptor inner segment; photoreceptor inner segment; myosin VII complex; synapse; cytoplasm; cytoplasm; cytoplasm; cytoplasm; cytoplasm; cytoplasm; cytoplasm; lysosomal membrane; cytosol; microvillus; apical plasma membrane; photoreceptor outer segment; cytoplasm; cytoplasm; cytoskeleton; myosin complex; cytoplasm; cell; cell; photoreceptor outer segment; melanosome
Molecular Function (21) ATP binding; protein domain specific binding; nucleotide binding; actin filament binding; protein complex binding; ADP binding; protein binding; protein binding; protein binding; protein binding; protein binding; protein binding; protein binding; actin-dependent ATPase activity; protein homodimerization activity; binding; microfilament motor activity; motor activity; calmodulin binding; calmodulin binding; actin binding
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
247
110
606
754
1183
385
Cochlea GFP+ cells
53
61
607
959
785
NA
Utricle GFP- cells
29
15
2
29
42
0
Cochlea GFP- cells
17
0
2
21
12
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
15
GFP+
523
33.46
2.04e-8
Utricle
283
Cochlea
252
0.89
1
Embryonic
66
Postnatal
385
5.76
0.00259
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17493467 123.44 ± 8.24 118.35 ± 18.95 [161.13] 0.96 0.702
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
121
118
134
117
No bFGF
52
51
58
45
EGF
22
24
26
24
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
117
No bFGF
45
0.39
0.213
bFGF
117
EGF
24
0.21
2.26e-18
No bFGF
45
EGF
24
0.53
0.00931
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000001044
Symbol MYO7A
Description Myosin VIIA
log10 riBAQ in stereocilia (mean ± sd) -3.41 ± 0.10
log10 riBAQ in utricle (mean ± sd) -2.94 ± 0.02
Molecules per stereocilium (mean ± error with slope error) 576.88 ± 24.54
Corrected Molecules per stereocilium (mean ± sd) 248.87 ± 443.61
Stereocilium / Utricle ratio (mean ± sd) 0.34 ± 0.02
Enriched in the stereocilia (FDR < 0.05) TRUE
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1421385_a_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 366.77 464.38 400.17 391.9 302.48 750.75
Replicate 1 Call A A P P P P
Replicate 2 345.12 383.82 373.07 540.48 321.97 543.76
Replicate 2 Call A A P P P P
Replicate 3 356.46 421.93 416.14 465.87 258.89 547.62
Replicate 3 Call A A P P P P
Replicate 4 384.29 371.99 199.76 414.25
Replicate 4 Call P P P P
Mean 356.12 423.38 393.42 442.56 270.78 564.1
Standard Deviation 10.83 40.3 18.79 76.76 54.19 139.02
Log2 Mean 8.48 8.72 8.62 8.77 8.06 9.11
Log2 Standard Deviation 0.04 0.14 0.07 0.25 0.31 0.35
 
Vestibular ganglion
Replicate 1 385.58 328.73 336.75 288.26 373.13 418.79
Replicate 1 Call A P A A A P
Replicate 2 356.33 306.91 309.73 321.14 417.17 409.28
Replicate 2 Call A A A A P P
Replicate 3 335.65 325.64 271.16 293.81 367.94 463.48
Replicate 3 Call A P A A A P
Mean 359.19 320.43 305.88 301.07 386.08 430.52
Standard Deviation 25.09 11.81 32.96 17.6 27.05 28.94
Log2 Mean 8.49 8.32 8.25 8.23 8.59 8.75
Log2 Standard Deviation 0.1 0.05 0.16 0.08 0.1 0.1