GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description lipoxygenase homology domains 1
Synonyms 1700096C21Rik; sba
Chromosome 18
Genetic Map Distance 52.20 cM
RefSeq Accessions NM_172834; NP_766422
NCBI Entrez Gene 240411 at chr18:77520697-77680996 (mm9) / chr18:77281949-77442932 (mm10)
Ensembl Gene ENSMUSG00000032818
VEGA Gene OTTMUSG00000025866
MGI Gene MGI:1914609
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
C8YR32 Lipoxygenase homology domain-containing protein 1 2068 0
D3YUR7 Uncharacterized protein 1478 0
Q8BI18 Putative uncharacterized protein 996 0
Pfam Domains PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT; PLAT
Mouse alleles (1)
Allele Name Allele Type
Loxhd1sba Chemically induced (ENU)
Human Homolog LOXHD1 (lipoxygenase homology domains 1)
Human synonyms DFNB77; LH2D1
Human cytoband 18q21.1
Known deafness gene DFNB77
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000001787 (LOXHD1) encoding ENSGALP00000002753
Gene Ontology
Biological Process (2) sensory perception of sound; sensory perception of sound
Cellular Component (2) cell projection; stereocilium
FACS-Sorted Hair Cells
Loxhd1 is not detected by RNA-Seq.
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17351963 255.37 ± 18.10 342.24 ± 72.78 [268.16] 1.34 0.516
Otic Progenitor Cells
Loxhd1 is not detected by RNA-Seq.
Chicken Stereocilium Proteomics
Protein ID ENSGALP00000002753
Symbol LOXHD1
Description Lipoxygenase homology domains 1
log10 riBAQ in stereocilia (mean ± sd) ND
log10 riBAQ in utricle (mean ± sd) -6.10 ± 0.29
Molecules per stereocilium (mean ± error with slope error) ND
Corrected Molecules per stereocilium (mean ± sd) ND
Stereocilium / Utricle ratio (mean ± sd) UTR only
Enriched in the stereocilia (FDR < 0.05) NA
Auditory and Vestibular Ganglion Neurons
No probes available for Loxhd1 on Affymetrix MOE430_2.0 GeneChip.