GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description lysine (K)-specific methyltransferase 2D
Synonyms C430014K11Rik; Mll2; Mll4
Chromosome 15
Genetic Map Distance 54.80 cM
RefSeq Accessions NM_001033276; NM_001033388; NP_001028448
NCBI Entrez Gene 381022 at chr15:98662100-98701614 (mm9) / chr15:98831669-98871205 (mm10)
Ensembl Gene ENSMUSG00000048154
VEGA Gene
MGI Gene MGI:2682319
Mouse Protein (3)
UniProt ID Description Length (AA) Predicted # TMs
Q3USM7 Putative uncharacterized protein 123 3
Q6PDK2 Histone-lysine N-methyltransferase MLL2 5588 0
Q3USG3 Putative uncharacterized protein 742 0
Pfam Domains
Mouse alleles (1)
Allele Name Allele Type
Mll2tm1(NCOM)Mfgc NorCOMM-projects
Human Homolog MLL2 (myeloid/lymphoid or mixed-lineage leukemia 2)
Human synonyms AAD10; ALR; CAGL114; KABUK1; KMS; KMT2B; KMT2D; MLL4; TNRC21
Human cytoband 12q13.12
Known deafness gene No
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (1)
ENSGALG00000012753 (LOC425846) encoding ENSGALP00000020783
Gene Ontology
Biological Process (15) chromatin silencing; oogenesis; oocyte growth; histone H3-K4 methylation; positive regulation of transcription from RNA polymerase II promoter; peptidyl-lysine methylation; histone lysine methylation; methylation; regulation of transcription; DNA-dependent; transcription; DNA-dependent; positive regulation of cell proliferation; positive regulation of intracellular estrogen receptor signaling pathway; response to estrogen stimulus; chromatin modification; in utero embryonic development
Cellular Component (3) histone methyltransferase complex; nucleus; nucleus
Molecular Function (8) DNA binding; transcription regulatory region DNA binding; transferase activity; methyltransferase activity; metal ion binding; histone-lysine N-methyltransferase activity; zinc ion binding; binding
FACS-Sorted Hair Cells
Kmt2d is not detected by RNA-Seq.
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17321365 41.16 ± 10.44 50.44 ± 11.49 [39.64] 1.23 0.682
Otic Progenitor Cells
Kmt2d is not detected by RNA-Seq.
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1427555_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 1319.39 1020.03 1569.33 1914.4 1200.24 1791.11
Replicate 1 Call A A A A A A
Replicate 2 1182.85 1263.58 1916.94 1937.55 1745.44 1678.15
Replicate 2 Call A A A A A A
Replicate 3 1346.02 1192.98 1898.14 2454.72 1340.35 1762.56
Replicate 3 Call A A A A A A
Replicate 4 2171.63 1797.75 1473.15 1923.29
Replicate 4 Call A A A A
Mean 1282.75 1158.86 1889.01 2026.11 1439.8 1788.78
Standard Deviation 87.54 125.31 246.94 292.22 232.24 101.69
Log2 Mean 10.32 10.17 10.87 10.97 10.48 10.8
Log2 Standard Deviation 0.1 0.16 0.19 0.2 0.23 0.08
 
Vestibular ganglion
Replicate 1 1519.4 1690.93 2344.24 2226.13 1911.7 821.75
Replicate 1 Call A A A A A A
Replicate 2 1239.21 1528.77 1728.5 2124.04 1799.38 1006.76
Replicate 2 Call A A A A A A
Replicate 3 1583.04 1767.68 1807.02 2073.22 1703.44 1077.39
Replicate 3 Call A A A A A A
Mean 1447.22 1662.46 1959.92 2141.13 1804.84 968.63
Standard Deviation 182.93 121.97 335.14 77.87 104.24 132.02
Log2 Mean 10.49 10.7 10.92 11.06 10.82 9.91
Log2 Standard Deviation 0.19 0.11 0.24 0.05 0.08 0.2