GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description potassium voltage-gated channel, subfamily Q, member 4
Synonyms
Chromosome 4
Genetic Map Distance 56.52 cM
RefSeq Accessions NM_001081142; NP_001074611
NCBI Entrez Gene 60613 at chr4:120370078-120419781 (mm9) / chr4:120696134-120747491 (mm10)
Ensembl Gene ENSMUSG00000028631
VEGA Gene OTTMUSG00000008856
MGI Gene MGI:1926803
Mouse Protein (1)
UniProt ID Description Length (AA) Predicted # TMs
Q9JK97 Potassium voltage-gated channel subfamily KQT member 4 696 5
Pfam Domains Ion_trans; KCNQ_channel
Mouse alleles (5)
Allele Name Allele Type
Kcnq4tm1e(EUCOMM)Hmgu EUCOMM-projects
Kcnq4tm1a(EUCOMM)Hmgu EUCOMM-projects
Kcnq4tm1.1Tjj Targeted (knock-out)
Kcnq4tm1.2Tjj Targeted (knock-in)
Kcnq4tm1Lex Targeted (knock-out)
Human Homolog KCNQ4 (potassium voltage-gated channel, KQT-like subfamily, member 4)
Human synonyms DFNA2; DFNA2A; KV7.4
Human cytoband 1p34
Known deafness gene DFNA2A
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (2)
ENSGALG00000003200 (Q2I2K5_CHICK) encoding ENSGALP00000005060
ENSGALG00000003200 (Q2I2K5_CHICK) encoding ENSGALP00000039974
Gene Ontology
Biological Process (12) transport; ion transport; ion transport; transmembrane transport; regulation of ion transmembrane transport; negative regulation of synaptic transmission; dopaminergic; potassium ion transport; potassium ion transport; potassium ion transmembrane transport; potassium ion transmembrane transport; inner ear morphogenesis; sensory perception of sound
Cellular Component (7) membrane; cytoplasm; voltage-gated potassium channel complex; plasma membrane; integral to membrane; neuron projection; membrane
Molecular Function (5) ion channel activity; ion channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
4
0
0
2
0
19
Cochlea GFP+ cells
0
2
0
1
0
NA
Utricle GFP- cells
0
1
2
1
0
0
Cochlea GFP- cells
0
0
0
0
1
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
0
GFP+
2
3.17
0.949
Utricle
2
Cochlea
0
0.24
1
Embryonic
1
Postnatal
2
1.82
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17429476 29.75 ± 6.50 236.85 ± 71.37 [123.06] 7.96 0.162
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
435
481
674
399
No bFGF
686
749
946
648
EGF
335
304
432
357
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
399
No bFGF
648
1.62
1
bFGF
399
EGF
357
0.89
0.462
No bFGF
648
EGF
357
0.55
2.32e-7
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
No probes available for Kcnq4 on Affymetrix MOE430_2.0 GeneChip.