GENE VIEW

MOUSE GENE INFORMATION [PubMed]
Description potassium voltage-gated channel, subfamily Q, member 1
Synonyms KVLQT1; Kcna9
Chromosome 7
Genetic Map Distance 88.12 cM
RefSeq Accessions NM_008434; NP_032460
NCBI Entrez Gene 16535 at chr7:150293159-150612947 (mm9) / chr7:143106840-143427044 (mm10)
Ensembl Gene ENSMUSG00000009545
VEGA Gene
MGI Gene MGI:108083
Mouse Protein (5)
UniProt ID Description Length (AA) Predicted # TMs
P97414 Potassium voltage-gated channel subfamily KQT member 1 668 6
Q3U4H1 Putative uncharacterized protein 668 6
Q8CJG2 Q1-type potassium channel spliced variant 440 6
Q3UWF6 Putative uncharacterized protein (Fragment) 326 0
Q99NF6 Potassium channel protein (Fragment) 204 0
Pfam Domains Ion_trans; CD225; KCNQ_channel
Mouse alleles (12)
Allele Name Allele Type
Kcnq1tm1e(EUCOMM)Hmgu EUCOMM-projects
Kcnq1tm1a(EUCOMM)Hmgu EUCOMM-projects
Kcnq1tm2e(EUCOMM)Hmgu EUCOMM-projects
Kcnq1tm1Apf Targeted (knock-out)
Kcnq1tm1Kpfe Targeted (knock-out)
Kcnq1tm2Kpfe Targeted (knock-in)
Kcnq1tm3Kpfe Targeted (knock-in)
Kcnq1tm4Kpfe Targeted (knock-in)
Kcnq1vtg-2J Spontaneous
Kcnq1vtg-3J Chemically induced (ENU)
Kcnq1vtg-4J Spontaneous
Kcnq1vtg Spontaneous
Human Homolog KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1)
Human synonyms ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS
Human cytoband 11p15.5
Known deafness gene JLNS1
Within mapped deafness loci No
Associated Human Disease in OMIM
Chicken homolog (3)
ENSGALG00000006472 (KCNQ1) encoding ENSGALP00000010441
ENSGALG00000006472 (KCNQ1) encoding ENSGALP00000038529
ENSGALG00000006472 (KCNQ1) encoding ENSGALP00000038530
Gene Ontology
Biological Process (16) regulation of gene expression by genetic imprinting; gene silencing; negative regulation of insulin secretion; potassium ion transmembrane transport; potassium ion transport; ion transport; ion transport; regulation of membrane repolarization; potassium ion export; transport; transmembrane transport; regulation of ion transmembrane transport; regulation of ion transmembrane transport; response to chemical stimulus; regulation of membrane potential; regulation of gene expression by genetic imprinting
Cellular Component (11) zymogen granule membrane; membrane; membrane; plasma membrane; integral to membrane; integral to plasma membrane; basolateral plasma membrane; voltage-gated potassium channel complex; cytoplasmic vesicle membrane; cytoplasmic vesicle; sarcolemma
Molecular Function (6) voltage-gated potassium channel activity; potassium channel activity; ion channel activity; ion channel activity; outward rectifier potassium channel activity; voltage-gated ion channel activity
FACS-Sorted Hair Cells
Data | Chart
E16a
E16b
P0
P4
P7
P16
Utricle GFP+ cells
0
0
6
2
7
6
Cochlea GFP+ cells
0
2
2
2
1
NA
Utricle GFP- cells
1
6
4
0
5
0
Cochlea GFP- cells
0
0
2
0
2
NA
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
GFP-
2
GFP+
2
1.37
0.914
Utricle
3
Cochlea
1
0.43
1
Embryonic
1
Postnatal
3
2.21
1
Adult Cochlear Inner and Outer Hair Cells
Probeset ID IHC (mean ± sd) OHC (mean ± sd) [OHC replicate] Fold Change (OHC/IHC) False Discovery Rate (FDR)
17485320 15.01 ± 0.54 15.39 ± 1.29 [12.40] 1.03 0.615
Otic Progenitor Cells
Data
Growth Factor
Replicate 1
Replicate 2
Replicate 3
Mean
bFGF
1
0
0
19
No bFGF
0
2
1
0
EGF
1
3
1
2
Analysis
Condition A
Mean A
Condition B
Mean B
Fold Change (B/A)
False Discovery Rate (FDR)
bFGF
19
No bFGF
0
0.05
0.000439
bFGF
19
EGF
2
0.12
5.82e-8
No bFGF
0
EGF
2
2.33
0.434
Chicken Stereocilium Proteomics
The chicken protein was not reproducibly detected in the chicken stereocilia.
Auditory and Vestibular Ganglion Neurons
Probe set ID: 1449464_at
Age E12 E13 E16 P0 P6 P15
Spiral ganglion
Replicate 1 33.04 53.78 46.98 73.65 300.83 165.97
Replicate 1 Call A A A A A A
Replicate 2 41.15 46.44 93.27 104.1 334.11 207.62
Replicate 2 Call A A A A A A
Replicate 3 34.09 40.42 65.83 95.46 185.82 178.11
Replicate 3 Call A A A A A A
Replicate 4 151.14 80.43 282.48 160.39
Replicate 4 Call A A A A
Mean 36.09 46.88 89.31 88.41 275.81 178.02
Standard Deviation 4.41 6.69 45.39 13.87 63.69 21.07
Log2 Mean 5.17 5.54 6.34 6.45 8.07 7.47
Log2 Standard Deviation 0.17 0.21 0.72 0.23 0.37 0.17
 
Vestibular ganglion
Replicate 1 47.72 40.74 116.17 104.28 131.96 90.29
Replicate 1 Call A A A A A A
Replicate 2 45.89 61.24 129.2 109.35 163.63 49.34
Replicate 2 Call A A A A A A
Replicate 3 59.03 47.85 147.06 121.63 113.77 110.76
Replicate 3 Call A A A A A A
Mean 50.88 49.94 130.81 111.75 136.45 83.46
Standard Deviation 7.12 10.41 15.51 8.92 25.23 31.27
Log2 Mean 5.66 5.62 7.02 6.8 7.08 6.3
Log2 Standard Deviation 0.2 0.3 0.17 0.11 0.26 0.61